<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JCARD</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Cardio</journal-id>
      <journal-title>JMIR Cardio</journal-title>
      <issn pub-type="epub">2561-1011</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v2i1e6</article-id>
    <article-id pub-id-type="pmid">31758766</article-id>
    <article-id pub-id-type="doi">10.2196/cardio.8574</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Measuring Moderate-Intensity Exercise with the Apple Watch: Validation Study</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Gomersall</surname>
          <given-names>Sjaan</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Bose</surname>
          <given-names>Tanushree</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Paglialonga</surname>
          <given-names>Alessia</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Di</surname>
          <given-names>Junrui</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes" equal-contrib="yes">
      <name name-style="western">
        <surname>Abt</surname>
        <given-names>Grant</given-names>
      </name>
      <degrees>PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>School of Life Sciences</institution>
        <institution>The University of Hull</institution>
        <addr-line>Cottingham Road</addr-line>
        <addr-line>Kingston upon Hull, HU6 7RX</addr-line>
        <country>United Kingdom</country>
        <phone>44 01482463397</phone>
        <email>g.abt@hull.ac.uk</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-4079-9270</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2" equal-contrib="yes">
        <name name-style="western">
          <surname>Bray</surname>
          <given-names>James</given-names>
        </name>
        <degrees>MSc</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-6073-4984</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3" equal-contrib="yes">
        <name name-style="western">
          <surname>Benson</surname>
          <given-names>Amanda Clare</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff2" ref-type="aff">2</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-2959-8969</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>School of Life Sciences</institution>
    <institution>The University of Hull</institution>  
    <addr-line>Kingston upon Hull</addr-line>
    <country>United Kingdom</country></aff>
    <aff id="aff2">
    <sup>2</sup>
    <institution>Department of Health and Medical Sciences</institution>
    <institution>Swinburne University of Technology</institution>  
    <addr-line>Melbourne</addr-line>
    <country>Australia</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Grant Abt 
      <email>g.abt@hull.ac.uk</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><season>Jan-Jun</season><year>2018</year></pub-date>
    <pub-date pub-type="epub">
      <day>28</day>
      <month>02</month>
      <year>2018</year>
    </pub-date>
    <volume>2</volume>
    <issue>1</issue>
    <elocation-id>e6</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>27</day>
        <month>7</month>
        <year>2017</year>
      </date>
      <date date-type="rev-request">
        <day>12</day>
        <month>9</month>
        <year>2017</year>
      </date>
      <date date-type="rev-recd">
        <day>1</day>
        <month>11</month>
        <year>2017</year>
      </date>
      <date date-type="accepted">
        <day>2</day>
        <month>1</month>
        <year>2018</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Grant Abt, James Bray, Amanda Clare Benson. Originally published in JMIR Cardio (http://cardio.jmir.org), 28.02.2018.</copyright-statement>
    <copyright-year>2018</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Cardio, is properly cited. The complete bibliographic information, a link to the original publication on http://cardio.jmir.org, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://cardio.jmir.org/2018/1/e6/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>Moderate fitness levels and habitual exercise have a protective effect for cardiovascular disease, stroke, type 2 diabetes, and all-cause mortality. The Apple Watch displays exercise completed at an intensity of a brisk walk or above using a green “exercise” ring. However, it is unknown if the exercise ring accurately represents an exercise intensity comparable to that defined as moderate-intensity. In order for health professionals to prescribe exercise intensity with confidence, consumer wearable devices need to be accurate and precise if they are to be used as part of a personalized medicine approach to disease management.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>The aim of this study was to examine the validity and reliability of the Apple Watch for measuring moderate-intensity exercise, as defined as 40-59% oxygen consumption reserve (VO<sub>2</sub>R).</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>Twenty recreationally active participants completed resting oxygen consumption (VO<sub>2</sub>rest) and maximal oxygen consumption (VO<sub>2</sub> max) tests prior to a series of 5-minute bouts of treadmill walking at increasing speed while wearing an Apple Watch on both wrists, and with oxygen consumption measured continuously. Five-minute exercise bouts were added until the Apple Watch advanced the green “exercise” ring by 5 minutes (defined as the treadmill inflection speed). Validity was examined using a one-sample t-test, with interdevice and intradevice reliability reported as the standardized typical error and intraclass correlation.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>The mean %VO<sub>2</sub>R at the treadmill inflection speed was 30% (SD 7) for both Apple Watches. There was a large underestimation of moderate-intensity exercise (left hand: mean difference = -10% [95% CI -14 to -7], d=-1.4; right hand: mean difference = -10% [95% CI -13 to -7], d=-1.5) when compared to the criterion of 40% VO<sub>2</sub>R. Standardized typical errors for %VO<sub>2</sub>R at the treadmill inflection speed were small to moderate, with intraclass correlations higher within trials compared to between trials.</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>The Apple Watch threshold for moderate-intensity exercise was lower than the criterion, which would lead to an overestimation of moderate-intensity exercise minutes completed throughout the day.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>smartwatch</kwd>
      <kwd>wearables</kwd>
      <kwd>technology</kwd>
      <kwd>physical activity</kwd>
      <kwd>cardiovascular health, Apple Watch</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Physical activity is well documented as a beneficial intervention for the prevention and treatment of chronic disease, while physical inactivity is an independent risk factor for the development of lifestyle-related chronic diseases, such as cardiovascular disease [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. To be considered “physically active” it is recommended that adults accumulate &#62;150 minutes of moderate or 75 minutes of vigorous-intensity physical activity (MVPA) over the course of a week to provide them with substantial health benefits [<xref ref-type="bibr" rid="ref3">3</xref>]. Given that the average adult expends approximately four metabolic equivalents walking at a moderate pace [<xref ref-type="bibr" rid="ref4">4</xref>], they would therefore need to walk at this pace for 125 minutes/week, or 30 minutes on most days of the week, to meet the minimum recommendations. Although these physical activity guidelines are strongly recommended by governments across the world [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref7">7</xref>], many people do not achieve them [<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. However, physical activity interventions that have incorporated technology-based support have shown promise in developing compliance to physical activity guidelines [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>], possibly through reinforcement to develop habit-forming behaviors [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>Although valid and reliable tools for measuring physical activity are available for researchers, such as the ActiGraph [<xref ref-type="bibr" rid="ref15">15</xref>], it is the quantified-self movement [<xref ref-type="bibr" rid="ref16">16</xref>] that has led to the increasing popularity of consumer wearable technology, with estimates indicating sales of over 200 million by 2021, including the Apple Watch [<xref ref-type="bibr" rid="ref17">17</xref>]. Having contemporary instruments to integrate into exercise prescription and physical activity promotion that fit into people’s lifestyles is imperative. Although evidence on the validity and reliability of modern wearable devices with integrated screens to measure exercise and physical activity is increasing, no study has examined the accuracy of the Apple Watch for measuring MVPA.</p>
        <p>Apple is one of the world’s most valuable companies (by market value) [<xref ref-type="bibr" rid="ref18">18</xref>] and has changed a number of industries through disruptive devices (eg, iPod, iPhone). The Apple Watch, which was released in 2015, has reportedly become the highest selling wearable/smartwatch to date, with more than 12 million units reported to have been sold [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. The widespread use of the Apple Watch would therefore allow physical activity interventions to reach a large proportion of the population. Additionally, the Apple Watch provides potential for data to be collected from, and returned to, the individual, to provide immediate individualized feedback via the wearable’s screen to promote behavior change and be shared with others, such as a clinician. However, Apple provides little detail on how the Apple Watch measures “exercise.” It appears that the built-in accelerometer is mostly used to measure physical activity throughout the day [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>], although heart rate measurement is used periodically when walking [<xref ref-type="bibr" rid="ref22">22</xref>]. Daily physical activity data is displayed within the “Activity” app, with a visual representation of the accumulated duration of “exercise” displayed as a green ring on the screen of the watch. Given that Apple refers to this as the “exercise” ring and that 30 minutes is the daily goal [<xref ref-type="bibr" rid="ref23">23</xref>], it is reasonable to suggest that Apple views this as representative of the daily goal of 30 minutes of MVPA for adults, as recommended by numerous guidelines [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref7">7</xref>]. Although Apple states that, “every full minute of movement that equals or exceeds the intensity of a brisk walk counts toward your daily exercise goal” [<xref ref-type="bibr" rid="ref23">23</xref>], it is not clear how this measure of MVPA compares to the criterion measure of moderate-intensity exercise, oxygen consumption reserve (VO<sub>2</sub>R: [VO<sub>2</sub>max - VO<sub>2</sub>rest] x exercise intensity + VO<sub>2</sub>rest).</p>
      </sec>
      <sec>
        <title>Objective of This Study</title>
        <p>Given the scale of smartwatch use around the world and the increasing attention on personalized medicine, the validity of the Apple Watch for measuring moderate-intensity exercise is important to examine. Establishing the validity of the Apple Watch would ensure that individuals are able to measure their own MVPA accurately and that health professionals have confidence in the data that their clients are sharing with them. Establishing the intradevice and interdevice reliability of the Apple Watch is also important so that daily measures can be compared, and that user preference for wearing the Watch on the left or right wrist does not introduce bias. Therefore, the aim of this study was to examine the validity and reliability of the Apple Watch for quantifying moderate-intensity exercise compared with directly measured VO<sub>2</sub>R.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design and Participants</title>
        <p>The study used a repeated measures design with each participant completing two main trials. Prior to the main trials, maximal oxygen consumption (VO<sub>2</sub>max) and resting oxygen consumption (VO<sub>2</sub>rest) were measured in all participants. The study was approved by the Department of Sport, Health and Exercise Science Ethics Committee (approval number 1516076) at the University of Hull. Given the paucity of data on the Apple Watch at the time of study commencement, the sample size was estimated based on a previous study [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
      </sec>
      <sec>
        <title>Recruitment</title>
        <p>Participants were recruited from the University of Hull and local community via written promotional material or personal communication. Inclusion criteria stated that participants were aged between 18 and 50 years, and exclusion criteria were: (1) men and women classified as moderate or high-risk according to the American College of Sports Medicine (ACSM) risk classification criteria, (2) those unable to walk on a motorized treadmill, (3) current smokers, (4) BMI &#62;30, and (5) those currently taking medication that alters the heart rate in response to exercise (eg, beta blockers). Inclusion and exclusion criteria were established with the aim of recruiting low-risk individuals, based on the ACSM risk classification criteria used at the commencement of the study.</p>
      </sec>
      <sec>
        <title>Data Collection</title>
        <sec>
          <title>Anthropometric</title>
          <p>Participants were asked if they had voided before attending the session; if not, they were instructed to do so. Participants were then instructed to remove all clothing and nude body mass was measured to the nearest 0.1 kg using digital scales (WB-100MA Mark 3, Tanita Corporation, Tokyo, Japan). The mean of two measurements was used for further analysis. Stretch stature was measured using a wall-mounted stadiometer (Holtain Ltd, Dyfed, Wales, UK) and according to the methods of the International Society for the Advancement of Kinanthropometry [<xref ref-type="bibr" rid="ref25">25</xref>].</p>
        </sec>
        <sec>
          <title>Familiarization</title>
          <p>Following medical screening and admission to the study, participants were familiarized with the tasks required of them during the main trials. This familiarization session consisted of the participant practicing “hopping on” and “hopping off” the treadmill, as well as walking at a number of dedicated speeds. This familiarization procedure was repeated at three of the speeds used in the main trials (ie, 3, 4.5, 6 km/hour).</p>
        </sec>
        <sec>
          <title>Resting Oxygen Consumption</title>
          <p>VO<sub>2</sub>rest was measured 30 minutes prior to, and in the same session, as VO<sub>2</sub> max in a temperature-controlled laboratory. Participants lay supine on a bed with their head on a pillow for approximately 22 minutes. Oxygen consumption was measured continuously from expired air using a breath-by-breath online gas analysis system (Cortex Metalyzer 3B, GmbH, Germany). The analyzer was calibrated prior to each test using room air and known gas concentrations of oxygen and carbon dioxide. Volume was calibrated using a 3-liter syringe.</p>
          <p>During the 22 minutes of measurement, the laboratory lights were turned off and all other laboratory activity was stopped. Prior to commencement of the measurement period, participants were instructed to relax as much as possible but to avoid going to sleep; they were not permitted to close their eyes. For analysis of the data, we discarded the first 10 minutes of data to allow for habituation and the last 2 minutes of data to allow for expectation effects. The mean of the remaining 10 minutes of data was taken as the VO<sub>2</sub>rest. Although we are not aware of any standardized method for measuring VO<sub>2</sub>rest for the purpose of calculating VO<sub>2</sub>R, we developed our method based on that reported by Miller et al [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
        </sec>
        <sec>
          <title>Maximal Oxygen Consumption</title>
          <p>Maximal oxygen consumption was determined on a motorized treadmill (h/p/cosmos, Pulsar, Nussdorf-Traunstein, Germany) using an incremental protocol that commenced at 3 km/hour and a 1% gradient and increased 0.5 km/hour in speed every 30 seconds until volitional fatigue. Oxygen consumption was measured continuously from expired air using the same breath-by-breath system as described above for VO<sub>2</sub>rest.</p>
        </sec>
        <sec>
          <title>Exercise Protocol</title>
          <p>For the 24 hours prior to each trial, participants were instructed to avoid exercise and maintain their normal diet, and for three hours prior to each trial avoid food and caffeinated drinks. On two separate occasions (mean 6 days apart, SD 3) participants completed a series of 5-minute bouts of walking on a treadmill at a gradient of 1%. Each bout was followed by 5-minutes of seated rest. On both occasions, the first 5-minute walking bout was conducted at 3 km/hour, with the treadmill speed increased for each successive 5-minute bout by 0.5 km/hour (ie, 3.5, 4). Exercise bouts were continued until at least 6 km/hour was completed, and until the Apple Watch indicated that all 5-minutes of that bout was at a sufficient intensity to accumulate 5-minutes of the green “exercise” ring, as displayed within the Activity app. The treadmill speed at which this occurred was defined as the “treadmill inflection speed.” During each 5-minute period of exercise, oxygen consumption and heart rate were recorded by an online gas analysis system (as described previously), a Polar chest strap (Polar T31, Polar Electro, OY, Finland), and an Apple Watch (described below) worn on each wrist. During each 5-minute period of exercise, participants were instructed to maintain their normal gait and were not permitted to hold the treadmill handrails. Immediately at the cessation of each 5-minute exercise period, participants were instructed to grasp the treadmill handrails and straddle the treadmill belt. Once the treadmill belt was stationary, a chair was placed on the treadmill and the participant was instructed to sit. During the recovery period participants were required to sit motionless with each hand resting on the treadmill handrail. This was done to ensure that no activity during the recovery period contributed to the green “exercise” ring. Five minutes of seated rest was provided to enable each Apple Watch to update the green “exercise” ring. In pilot testing it was observed that the Apple Watch completed its update within a maximum of 5 minutes of rest following exercise. The mean oxygen consumption of the last three minutes at the treadmill inflection speed for each watch was used for later analysis.</p>
          <p>Two first-generation (Series 0) Apple Watches running watchOS 2.0.1 were used to estimate moderate-intensity exercise. Each Apple Watch was paired to an iPhone 6 running iOS 9.1. Following each 5-minute rest period the number of “exercise” minutes, as measured by each of the Apple Watches, was manually recorded from the Activity app.</p>
          <p>Moderate-intensity exercise is defined by the ACSM as that which elicits an oxygen consumption of between 40% and 59% of VO<sub>2</sub>R. By rearranging the equation provided by the ACSM (see below) [<xref ref-type="bibr" rid="ref3">3</xref>] and substituting target volume of oxygen (VO<sub>2</sub>) for the measured oxygen consumption at the treadmill inflection speed, the percentage of VO<sub>2</sub>R at the treadmill inflection speed (exercise intensity in the equation) can be calculated: Target VO<sub>2</sub>= (VO<sub>2</sub>max - VO<sub>2</sub>rest) x exercise intensity + VO<sub>2</sub>rest.</p>
        </sec>
      </sec>
      <sec>
        <title>Statistical Analyses</title>
        <p>Data were checked for normality using the Shapiro-Wilk test and graphical methods, and were found to be plausible. The VO<sub>2</sub>R during Trial 2 was used to assess the validity of the Apple Watch for measuring moderate-intensity exercise, with VO<sub>2</sub>R during both Trial 1 and 2 used to assess the interdevice and intradevice reliability. A one-sample t-test was used to test if the mean %VO<sub>2</sub>R at the treadmill inflection speed for each Apple Watch was different from 40%, which is the lower limit of moderate-intensity exercise. A custom-designed Excel spreadsheet was used to examine differences between left and right Apple Watches for treadmill inflection speed and %VO<sub>2</sub>R [<xref ref-type="bibr" rid="ref27">27</xref>]. Pearson product-moment correlation was used to assess the association between VO<sub>2</sub>max and the %VO<sub>2</sub>R at the treadmill inflection speed. Based on the linear association between VO<sub>2</sub>max and %VO<sub>2</sub>R, linear regression was used to estimate the VO<sub>2</sub> max and treadmill speed required for the Apple Watch to accurately measure moderate-intensity exercise. Interdevice and intradevice reliability is reported as the standardized typical error and intraclass correlation. Standardized typical error was doubled prior to assessing its magnitude [<xref ref-type="bibr" rid="ref28">28</xref>]. Standardized effect size is reported as Cohen’s <italic>d</italic> using the between-subject pooled SD as the denominator. The scale of magnitudes used to evaluate Cohen’s <italic>d</italic> was: 0-0.19 <italic>trivial</italic>; 0.2-0.59 <italic>small</italic>; 0.6-1.19 <italic>moderate</italic>; 1.2-1.99 <italic>large</italic>; &#62;2.0 <italic>very large</italic> [<xref ref-type="bibr" rid="ref28">28</xref>]. Uncertainty in the population estimates are reported as 95% CIs.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>Twenty (10 male, 10 female) recreationally active participants (mean age 32 years [SD 10]; body mass 71.4 kg [SD 14.2]; stature 174.5 cm [SD 7.2]) provided written informed consent to undertake a maximal exercise test and the research exercise protocol. Participants had their cardiovascular risk assessed using the ACSM risk classification guidelines [<xref ref-type="bibr" rid="ref3">3</xref>], with all participants classified as low risk.</p>
      <p>The mean VO<sub>2</sub>max and VO<sub>2</sub>rest, as measured using the online gas analysis system, were 45 mL/kg/minute (SD 10) and 3.4 mL/kg/minute (SD 0.6), respectively. The mean treadmill “inflection” speeds that were required to advance the Apple Watch green exercise ring by 5 minutes were 5.6 km/hour (SD 0.5) and 5.6 km/hour (SD 0.5) for the left and right Apple Watches, respectively (mean difference: 0 km/hour [95% CI -0.1 to 0.2], <italic>d</italic>=0.05 [trivial]). The mean %VO<sub>2</sub>R at the treadmill inflection speed for the left and right Apple Watches were 30% (SD 7) and 30% (SD 7), respectively (mean difference: 0% [95% CI -1 to 2], <italic>d</italic>=0.02 [trivial]). When compared to the criterion threshold of 40% VO<sub>2</sub>R, this represents a large underestimation in the ability of the Apple Watch to measure moderate-intensity exercise (left: mean difference = -10 [95% CI -14 to -7], <italic>d</italic>=-1.4 [large]; right: mean difference = -10 [95% CI -13 to -7], <italic>d</italic>=-1.5 [large]). The %VO<sub>2</sub>R at the treadmill inflection speed for each participant and each watch is displayed, together with the mean and 95% CI for both watches, in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p>
      <p>There was a very large negative correlation between %VO<sub>2</sub>R at the treadmill inflection speed and VO<sub>2</sub>max for the left Apple Watch (<xref ref-type="fig" rid="figure2">Figure 2</xref>), and a large negative correlation between %VO<sub>2</sub>R at the treadmill inflection speed and VO<sub>2</sub>max for the right Apple Watch (<xref ref-type="fig" rid="figure3">Figure 3</xref>). Participants with a higher VO<sub>2</sub>max were exercising at a lower percentage of their VO<sub>2</sub>R at the treadmill inflection speed (<xref ref-type="fig" rid="figure2">Figures 2</xref> and <xref ref-type="fig" rid="figure3">3</xref>). For the Apple Watch to accurately measure moderate-intensity exercise (40-59% VO<sub>2</sub>R), based on the regression equation for the left Watch, the user would need a VO<sub>2</sub>max between 16 (95% CI -3 to 36) and 35 (95% CI 19 to 50) mL/kg/minute. Based on within-participant linear regression analyses using the VO<sub>2</sub>R at each speed, we estimate that to achieve 40% of VO<sub>2</sub>R, participants would need to walk at a mean treadmill speed of 7.7 km/hour (95% CI 6.7 to 8.6) at 1% incline; which is 2.1 km/hour faster than that predicted by the Apple Watch. Only one participant had a comparable treadmill speed estimate for 40% VO<sub>2</sub>R between the Apple Watch and the online gas analysis system. Interdevice and intradevice reliability statistics for both treadmill speed and VO<sub>2</sub>R are displayed in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>The oxygen consumption reserve (%VO<sub>2</sub>R) at the treadmill inflection speed for each participant and each watch compared with the moderate-intensity zone.</p>
        </caption>
        <graphic xlink:href="cardio_v2i1e6_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <fig id="figure2" position="float">
        <label>Figure 2</label>
        <caption>
          <p>Pearson correlation between oxygen consumption reserve (%VO<sub>2</sub>R) at the treadmill inflection speed and maximal oxygen consumption (VO<sub>2</sub>max) for the left Apple Watch.</p>
        </caption>
        <graphic xlink:href="cardio_v2i1e6_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <fig id="figure3" position="float">
        <label>Figure 3</label>
        <caption>
          <p>Pearson correlation between oxygen consumption reserve (%VO<sub>2</sub>R) at the treadmill inflection speed and maximal oxygen consumption (VO<sub>2</sub>max) for the right Apple Watch.</p>
        </caption>
        <graphic xlink:href="cardio_v2i1e6_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Intradevice and interdevice reliability for both treadmill speed and oxygen consumption reserve (VO<sub>2</sub>R) for left and right Apple Watches.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="30"/>
          <col width="280"/>
          <col width="175"/>
          <col width="175"/>
          <col width="175"/>
          <col width="150"/>
          <thead>
            <tr valign="top">
              <td colspan="2">Parameter</td>
              <td>Trial 1 Left vs<break/>Trial 1 Right</td>
              <td>Trial 2 Left vs<break/>Trial 2 Right</td>
              <td>Trial 1 Left vs<break/>Trial 2 Left</td>
              <td>Trial 1 Right vs<break/>Trial 2 Right</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td colspan="2"><bold>Speed</bold></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Standardized typical error (95% CI)</td>
              <td>0.41 (0.31 to 0.60)</td>
              <td>0.54 (0.41 to 0.79)</td>
              <td>0.53 (0.40 to 0.79)</td>
              <td>0.64 (0.49 to 0.92)</td>
            </tr>

 <tr valign="top">
              <td><break/></td>
              <td>Qualitative interpretation</td>
              <td>Moderate</td>
              <td>Moderate</td>
              <td>Moderate</td>
              <td>Large</td>
            </tr>


            <tr valign="top">
              <td><break/></td>
              <td>Intraclass correlation (95% CI)</td>
              <td>0.87 (0.70 to 0.95)</td>
              <td>0.79 (0.55 to 0.91)</td>
              <td>0.80 (0.55 to 0.92)</td>
              <td>0.73 (0.45 to 0.88)</td>
            </tr>
            <tr valign="top">
              <td colspan="2"><bold>VO<sub>2</sub>R</bold></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Standardized typical error (95% CI)</td>
              <td>0.2 (0.15 to 0.29)</td>
              <td>0.33 (0.25 to 0.50)</td>
              <td>0.48 (0.36 to 0.71)</td>
              <td>0.37 (0.28 to 0.54)</td>
            </tr>

<tr valign="top">
              <td><break/></td>
              <td>Qualitative interpretation</td>
              <td>Small</td>
              <td>Moderate</td>
              <td>Moderate</td>
              <td>Moderate</td>
            </tr>


            <tr valign="top">
              <td><break/></td>
              <td>Intraclass correlation (95% CI)</td>
              <td>0.97 (0.92 to 0.99)</td>
              <td>0.91 (0.78 to 0.96)</td>
              <td>0.83 (0.61 to 0.93)</td>
              <td>0.89 (0.75 to 0.95)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This is the first study to investigate the validity and reliability of the Apple Watch for measuring moderate-intensity exercise (the green “exercise” ring) compared to the criterion measure of VO<sub>2</sub>R. The Apple Watch largely underestimated the walking speed required to elicit the lower bound of moderate-intensity exercise (40% VO<sub>2</sub>R), which is an important part of individualized [<xref ref-type="bibr" rid="ref3">3</xref>] and population-based [<xref ref-type="bibr" rid="ref29">29</xref>] exercise prescription guidelines. The standardized typical error, a measure of the “typical” test-retest variability presented in units of SD [<xref ref-type="bibr" rid="ref28">28</xref>], was small to moderate with no mean difference between the left and right watches for the mean treadmill inflection speed or %VO<sub>2</sub>R for the lower limit of moderate-intensity exercise [<xref ref-type="bibr" rid="ref3">3</xref>].</p>
        <p>For less fit individuals (&#60;35 mL/kg/minute), using the Apple Watch to monitor moderate-intensity exercise is more likely to have the expected and desired improvements to fitness or clinical outcomes than for fitter individuals. However, for those that are fitter (&#62;35 mL/kg/minute) it appears from our data that individuals would not meet the expectations of the lower end (40% VO<sub>2</sub>R) of the moderate-intensity range [<xref ref-type="bibr" rid="ref3">3</xref>], with the Apple Watch underestimating the threshold for moderate-intensity exercise, and therefore overestimating the number of minutes of moderate-intensity exercise an individual had completed. Thompson et al [<xref ref-type="bibr" rid="ref30">30</xref>] recently came to a similar conclusion, reporting that commercially-available wearable devices for self-monitoring of physical activity overestimate MVPA by a factor of 5-to-7-fold because they capture all physical activity, including normal moderate-to-vigorous lifestyle activities. However, other recent studies have reported that Fitbit devices (Fitbit One and Fitbit Flex) underestimate MVPA [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>], although in these studies the wearable device was compared against another wearable device (ActiGraph), not direct laboratory-measured moderate-intensity exercise as we have done in our study. In our study only two participants achieved a %VO<sub>2</sub>R within the moderate-intensity exercise zone (<xref ref-type="fig" rid="figure1">Figure 1</xref>). Apart from the impact this may have on the expected physiological adaptations and fitness, it also has potential implications for morbidity and mortality risk, as moderate fitness levels and habitual exercise have a protective effect for cardiovascular disease, stroke, type 2 diabetes, and all-cause mortality [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
        <p>Measuring load in an individual is complicated with a variety of methods available to monitor internal and external load [<xref ref-type="bibr" rid="ref34">34</xref>]. The Apple Watch does not substantially overestimate or underestimate heart rate [<xref ref-type="bibr" rid="ref24">24</xref>] and has moderate interdevice variability of maximal heart rate when worn on each wrist [<xref ref-type="bibr" rid="ref35">35</xref>]. Therefore, using a continuous combination of internal (heart rate) and external (accelerometer) training load measures [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>] rather than using the accelerometer plus periodic use of heart rate as is currently used, may improve the accuracy of the green exercise ring and provide a greater personalization of the data available to an individual. Given the wide range of VO<sub>2</sub>R responses observed at the treadmill speed that the Apple Watch determined to be “exercise” (&#60;20% to &#62;40%), and the variability between left and right Watches (<xref ref-type="fig" rid="figure1">Figure 1</xref>), it is clear that the Apple Watch needs to provide a more appropriate measure of the individualized response to exercise. This would not only enable more tailored feedback and exercise prescription, it would likely improve the physiological adaptations to any training and the associated cardiometabolic and musculoskeletal improvements for chronic disease prevention and treatment [<xref ref-type="bibr" rid="ref33">33</xref>]. Better compliance to guidelines [<xref ref-type="bibr" rid="ref13">13</xref>] and improved disease management and confidence [<xref ref-type="bibr" rid="ref37">37</xref>] have been reported in healthy and chronic disease populations when technology-based support is incorporated. However, consumer and health professionals need to have confidence that any wearable device can both consistently and accurately measure the exercise intensity for individuals of all fitness levels.</p>
        <p>The reliability data (<xref ref-type="table" rid="table1">Table 1</xref>) suggest that the reliability of VO<sub>2</sub>R at the point where the Apple Watch determines that “exercise” has started (the treadmill inflection speed) is better within trials (interdevice) than between trials (intradevice). This finding would suggest that physical activity measurements are more reliable within the same training session or activity compared to between different training sessions or activities. The implication is that health professionals can be confident that the ability of the Apple Watch to measure physical activity (as used in the current study) is not adversely affected by the wrist (left or right) on which an individual wore the watch within a given training session or activity.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>The main strength of our study is that this is the first investigation to examine the validity of the Apple Watch for measuring aspects of exercise related to the achievement of daily MVPA. The main limitation of this study is that we did not have direct access to the algorithms used by the Apple Watch for determining the exercise intensity at which the green “exercise” ring advances. Unfortunately, Apple does not publish these algorithms, probably due to commercial reasons. However, this is a limitation with most commercially-available wearable devices and is not restricted to the Apple Watch. A second limitation is that our data were derived from first generation Apple Watches. Although the method Apple uses to determine “exercise” using the Activity app has changed slightly with the periodic measurement of heart rate during walking [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>], it is unclear how this would affect the validity of the Apple Watch for measuring MVPA. Further studies are required using the latest generation of Apple Watch for this to be determined. The exercise protocols used in our study were also constrained to linear walking on a treadmill. Movement patterns used by people outside of the laboratory while wearing an Apple Watch may result in different physiological responses and different determinations of “exercise” by the Apple Watch. Fourth, although our primary measure was VO<sub>2</sub>R, there are a number of factors that can influence the oxygen cost of exercise, such as economy [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. For example, economy has been reported to be affected by age, such that older adults have less economy when walking compared to younger people [<xref ref-type="bibr" rid="ref40">40</xref>]. The mean age of our participants was 32 years (SD 10), which places our participants midway between the young and old adults participating in the study of Martin et al [<xref ref-type="bibr" rid="ref40">40</xref>]. Although factors such as economy and age should be taken into account when interpreting our results, the use of %VO<sub>2</sub>R as a relative measure of oxygen cost means that between-individual comparisons should still be meaningful.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>The Series 0 Apple Watch underestimates the threshold for moderate-intensity exercise compared to the criterion measure of VO<sub>2</sub>R, which would result in an overestimation of the amount of MVPA undertaken throughout the day. This effect is more pronounced in fitter individuals.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">ACSM</term>
          <def>
            <p>American College of Sports Medicine</p>
          </def>
        </def-item>
      
        <def-item>
          <term id="abb2">MVPA</term>
          <def>
            <p>moderate-vigorous physical activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">VO<sub>2</sub></term>
          <def>
            <p>volume of oxygen</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">VO<sub>2</sub>max</term>
          <def>
            <p>maximal oxygen consumption</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">VO<sub>2</sub>R</term>
          <def>
            <p>oxygen consumption reserve</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">VO<sub>2</sub>rest</term>
          <def>
            <p>resting oxygen consumption</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>GA, JB, and ACB designed the study. GA and JB collected the data. GA, JB, and ACB analyzed the data. GA, JB, and ACB prepared and revised the manuscript.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Haskell</surname>
            <given-names>WL</given-names>
          </name>
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Pate</surname>
            <given-names>RR</given-names>
          </name>
          <name name-style="western">
            <surname>Powell</surname>
            <given-names>KE</given-names>
          </name>
          <name name-style="western">
            <surname>Blair</surname>
            <given-names>SN</given-names>
          </name>
          <name name-style="western">
            <surname>Franklin</surname>
            <given-names>BA</given-names>
          </name>
          <name name-style="western">
            <surname>Macera</surname>
            <given-names>CA</given-names>
          </name>
          <name name-style="western">
            <surname>Heath</surname>
            <given-names>GW</given-names>
          </name>
          <name name-style="western">
            <surname>Thompson</surname>
            <given-names>PD</given-names>
          </name>
          <name name-style="western">
            <surname>Bauman</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association</article-title>
        <source>Med Sci Sports Exerc</source>  
        <year>2007</year>  
        <month>08</month>  
        <volume>39</volume>  
        <issue>8</issue>  
        <fpage>1423</fpage>  
        <lpage>34</lpage>  
        <pub-id pub-id-type="doi">10.1249/mss.0b013e3180616b27</pub-id>
        <pub-id pub-id-type="medline">17762377</pub-id>
        <pub-id pub-id-type="pii">00005768-200708000-00027</pub-id></nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wilmot</surname>
            <given-names>EG</given-names>
          </name>
          <name name-style="western">
            <surname>Edwardson</surname>
            <given-names>CL</given-names>
          </name>
          <name name-style="western">
            <surname>Achana</surname>
            <given-names>FA</given-names>
          </name>
          <name name-style="western">
            <surname>Davies</surname>
            <given-names>MJ</given-names>
          </name>
          <name name-style="western">
            <surname>Gorely</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Gray</surname>
            <given-names>LJ</given-names>
          </name>
          <name name-style="western">
            <surname>Khunti</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Yates</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Biddle</surname>
            <given-names>SJH</given-names>
          </name>
        </person-group>
        <article-title>Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis</article-title>
        <source>Diabetologia</source>  
        <year>2012</year>  
        <month>11</month>  
        <volume>55</volume>  
        <issue>11</issue>  
        <fpage>2895</fpage>  
        <lpage>905</lpage>  
        <pub-id pub-id-type="doi">10.1007/s00125-012-2677-z</pub-id>
        <pub-id pub-id-type="medline">22890825</pub-id></nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Pescatello</surname>
            <given-names>LS</given-names>
          </name>
        </person-group>
        <source>American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 9th edition</source>  
        <year>2014</year>  
        <publisher-loc>Philadelphia, PA</publisher-loc>
        <publisher-name>Wolters Kluwer/Lippincott Williams &#38; Wilkins Health</publisher-name></nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Brooks</surname>
            <given-names>AG</given-names>
          </name>
          <name name-style="western">
            <surname>Gunn</surname>
            <given-names>SM</given-names>
          </name>
          <name name-style="western">
            <surname>Withers</surname>
            <given-names>RT</given-names>
          </name>
          <name name-style="western">
            <surname>Gore</surname>
            <given-names>CJ</given-names>
          </name>
          <name name-style="western">
            <surname>Plummer</surname>
            <given-names>JL</given-names>
          </name>
        </person-group>
        <article-title>Predicting walking METs and energy expenditure from speed or accelerometry</article-title>
        <source>Med Sci Sports Exerc</source>  
        <year>2005</year>  
        <month>07</month>  
        <volume>37</volume>  
        <issue>7</issue>  
        <fpage>1216</fpage>  
        <lpage>23</lpage>  
        <pub-id pub-id-type="medline">16015141</pub-id>
        <pub-id pub-id-type="pii">00005768-200507000-00020</pub-id></nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>Australian Government Department of Health</collab>
        </person-group>
        <source>Evidence Summary</source>  
        <comment>Australia's physical activity and sedentary behaviour guidelines: guidelines evidence summary 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.health.gov.au/internet/main/publishing.nsf/Content/health-pubhlth-strateg-phys-act-guidelines/$File/Guideline">http://www.health.gov.au/internet/main/publishing.nsf/Content/health-pubhlth-strateg-phys-act-guidelines/$File/Guideline</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sCX8Qmia"/></comment> </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bull</surname>
            <given-names>F</given-names>
          </name>
          <name name-style="western">
            <surname>Biddle</surname>
            <given-names>SJH</given-names>
          </name>
          <name name-style="western">
            <surname>Buchner</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Ferguson</surname>
            <given-names>RA</given-names>
          </name>
          <name name-style="western">
            <surname>Foster</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Fox</surname>
            <given-names>KR</given-names>
          </name>
          <name name-style="western">
            <surname>Haskell</surname>
            <given-names>WL</given-names>
          </name>
          <name name-style="western">
            <surname>Mutrie</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Murphy</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Reilly</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Riddoch</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Skelton</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Stratton</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Tremblay</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Watts</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <source>Physical activity guidelines in the UK: Review and recommendations</source>  
        <year>2010</year>  
        <month>05</month>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/213743/dh_128255.pdf">https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/213743/dh_128255.pdf</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sDUGXr1L"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="web">
        <source>U.S. Department of Health and Human Services</source>  
        <year>2018</year>  
        <comment>Physical activity guidelines for Americans 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://health.gov/paguidelines/pdf/paguide.pdf">https://health.gov/paguidelines/pdf/paguide.pdf</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDVpHqVO"/></comment> </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Marcus</surname>
            <given-names>BH</given-names>
          </name>
          <name name-style="western">
            <surname>Dubbert</surname>
            <given-names>PM</given-names>
          </name>
          <name name-style="western">
            <surname>Forsyth</surname>
            <given-names>LH</given-names>
          </name>
          <name name-style="western">
            <surname>McKenzie</surname>
            <given-names>TL</given-names>
          </name>
          <name name-style="western">
            <surname>Stone</surname>
            <given-names>EJ</given-names>
          </name>
          <name name-style="western">
            <surname>Dunn</surname>
            <given-names>AL</given-names>
          </name>
          <name name-style="western">
            <surname>Blair</surname>
            <given-names>SN</given-names>
          </name>
        </person-group>
        <article-title>Physical activity behavior change: issues in adoption and maintenance</article-title>
        <source>Health Psychol</source>  
        <year>2000</year>  
        <month>01</month>  
        <volume>19</volume>  
        <issue>1S</issue>  
        <fpage>32</fpage>  
        <lpage>41</lpage>  
        <pub-id pub-id-type="medline">10709946</pub-id></nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tucker</surname>
            <given-names>JM</given-names>
          </name>
          <name name-style="western">
            <surname>Welk</surname>
            <given-names>GJ</given-names>
          </name>
          <name name-style="western">
            <surname>Beyler</surname>
            <given-names>NK</given-names>
          </name>
        </person-group>
        <article-title>Physical activity in U.S.: adults compliance with the Physical Activity Guidelines for Americans</article-title>
        <source>Am J Prev Med</source>  
        <year>2011</year>  
        <month>04</month>  
        <volume>40</volume>  
        <issue>4</issue>  
        <fpage>454</fpage>  
        <lpage>61</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.amepre.2010.12.016</pub-id>
        <pub-id pub-id-type="medline">21406280</pub-id>
        <pub-id pub-id-type="pii">S0749-3797(11)00012-2</pub-id></nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="web">
        <source>World Health Organization</source>  
        <year>2018</year>  
        <comment>Prevalence of insufficient physical activity 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.who.int/gho/ncd/risk_factors/physical_activity_text/en/">http://www.who.int/gho/ncd/risk_factors/physical_activity_text/en/</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDWHSwOw"/></comment> </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Zhao</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Ford</surname>
            <given-names>ES</given-names>
          </name>
          <name name-style="western">
            <surname>Li</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Mokdad</surname>
            <given-names>AH</given-names>
          </name>
        </person-group>
        <article-title>Compliance with physical activity recommendations in US adults with diabetes</article-title>
        <source>Diabet Med</source>  
        <year>2008</year>  
        <month>02</month>  
        <volume>25</volume>  
        <issue>2</issue>  
        <fpage>221</fpage>  
        <lpage>7</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1464-5491.2007.02332.x</pub-id>
        <pub-id pub-id-type="medline">18201213</pub-id>
        <pub-id pub-id-type="pii">DME2332</pub-id></nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fjeldsoe</surname>
            <given-names>BS</given-names>
          </name>
          <name name-style="western">
            <surname>Miller</surname>
            <given-names>YD</given-names>
          </name>
          <name name-style="western">
            <surname>Marshall</surname>
            <given-names>AL</given-names>
          </name>
        </person-group>
        <article-title>MobileMums: a randomized controlled trial of an SMS-based physical activity intervention</article-title>
        <source>Ann Behav Med</source>  
        <year>2010</year>  
        <month>05</month>  
        <volume>39</volume>  
        <issue>2</issue>  
        <fpage>101</fpage>  
        <lpage>11</lpage>  
        <pub-id pub-id-type="doi">10.1007/s12160-010-9170-z</pub-id>
        <pub-id pub-id-type="medline">20174902</pub-id></nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hurling</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Catt</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Boni</surname>
            <given-names>MD</given-names>
          </name>
          <name name-style="western">
            <surname>Fairley</surname>
            <given-names>BW</given-names>
          </name>
          <name name-style="western">
            <surname>Hurst</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Murray</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Richardson</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Sodhi</surname>
            <given-names>JS</given-names>
          </name>
        </person-group>
        <article-title>Using Internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial</article-title>
        <source>J Med Internet Res</source>  
        <year>2007</year>  
        <volume>9</volume>  
        <issue>2</issue>  
        <fpage>e7</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2007/2/e7/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.9.2.e7</pub-id>
        <pub-id pub-id-type="medline">17478409</pub-id>
        <pub-id pub-id-type="pii">v9i2e7</pub-id>
        <pub-id pub-id-type="pmcid">PMC1874722</pub-id></nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gardner</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Lally</surname>
            <given-names>P</given-names>
          </name>
        </person-group>
        <article-title>Does intrinsic motivation strengthen physical activity habit? Modeling relationships between self-determination, past behaviour, and habit strength</article-title>
        <source>J Behav Med</source>  
        <year>2013</year>  
        <month>10</month>  
        <volume>36</volume>  
        <issue>5</issue>  
        <fpage>488</fpage>  
        <lpage>97</lpage>  
        <pub-id pub-id-type="doi">10.1007/s10865-012-9442-0</pub-id>
        <pub-id pub-id-type="medline">22760451</pub-id></nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Migueles</surname>
            <given-names>JH</given-names>
          </name>
          <name name-style="western">
            <surname>Cadenas-Sanchez</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Ekelund</surname>
            <given-names>U</given-names>
          </name>
          <name name-style="western">
            <surname>Delisle</surname>
            <given-names>NC</given-names>
          </name>
          <name name-style="western">
            <surname>Mora-Gonzalez</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Löf</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Labayen</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Ruiz</surname>
            <given-names>JR</given-names>
          </name>
          <name name-style="western">
            <surname>Ortega</surname>
            <given-names>FB</given-names>
          </name>
        </person-group>
        <article-title>Accelerometer data collection and processing criteria to assess physical activity and other outcomes: a systematic review and practical considerations</article-title>
        <source>Sports Med</source>  
        <year>2017</year>  
        <month>09</month>  
        <volume>47</volume>  
        <issue>9</issue>  
        <fpage>1821</fpage>  
        <lpage>1845</lpage>  
        <pub-id pub-id-type="doi">10.1007/s40279-017-0716-0</pub-id>
        <pub-id pub-id-type="medline">28303543</pub-id>
        <pub-id pub-id-type="pii">10.1007/s40279-017-0716-0</pub-id></nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>King</surname>
            <given-names>AC</given-names>
          </name>
          <name name-style="western">
            <surname>Glanz</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Patrick</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Technologies to measure and modify physical activity and eating environments</article-title>
        <source>Am J Prev Med</source>  
        <year>2015</year>  
        <month>05</month>  
        <volume>48</volume>  
        <issue>5</issue>  
        <fpage>630</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.amepre.2014.10.005</pub-id>
        <pub-id pub-id-type="medline">25891063</pub-id>
        <pub-id pub-id-type="pii">S0749-3797(14)00582-0</pub-id></nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
<nlm-citation citation-type="web"> <source>IDC</source> <year>2017</year> <month>12</month> <day>20</day> <comment>IDC Forecasts Shipments of Wearable Devices to Nearly Double by 2021 as Smart Watches and New Product Categories Gain Traction<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.idc.com/getdoc.jsp?containerId=prUS43408517&#38;pageType=PRINTFRIENDLY">https://www.idc.com/getdoc.jsp?containerId=prUS43408517&#38;pageType=PRINTFRIENDLY</ext-link> <ext-link ext-link-type="webcite" xlink:href="6sDVA8fTG"/> </comment> </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="web">
        <source>Forbes</source>  
        <access-date>2017-07-25</access-date>
        <comment>The World's Most Valuable Brands 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.forbes.com/powerful-brands/list/">https://www.forbes.com/powerful-brands/list/</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDUhrhbx"/></comment> </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="web">
        <source>Canalys</source>  
        <year>2016</year>  
        <comment>Apple shipped two-thirds of all smart watches in 2015 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.canalys.com/static/press_release/2016/media-alert-05022016-apple-shipped-two-thirds-all-smart-watches-2015.pdf">https://www.canalys.com/static/press_release/2016/media-alert-05022016-apple-shipped-two-thirds-all-smart-watches-2015.pdf</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDUWcNOp"/></comment> </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="web">
        <source>Canalys</source>  
        <year>2017</year>  
        <month>02</month>  
        <day>07</day>  
        <access-date>2017-07-25</access-date>
        <comment>Apple Watch has its best quarter and takes nearly 80% of total smartwatch revenue in Q4 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.canalys.com/newsroom/media-alert-apple-watch-has-its-best-quarter-and-takes-nearly-80-total-smartwatch-revenue-q">https://www.canalys.com/newsroom/media-alert-apple-watch-has-its-best-quarter-and-takes-nearly-80-total-smartwatch-revenue-q</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDXRZXe1"/></comment> </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="web">
        <source>Apple</source>  
        <year>2018</year>  
        <access-date>2017-12-27</access-date>
        <comment>Get the most accurate measurements using your Apple Watch 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://support.apple.com/en-au/HT207941">https://support.apple.com/en-au/HT207941</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6w12bNAeg"/></comment> </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="web">
        <source>Apple</source>  
        <year>2018</year>  
        <access-date>2017-12-27</access-date>
        <comment>Your heart rate. What it means, and where on Apple Watch you'll find it 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://support.apple.com/en-au/HT204666">https://support.apple.com/en-au/HT204666</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6w1EXG9XM"/></comment> </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="web">
        <source>Apple</source>  
        <year>2018</year>  
        <access-date>2017-07-24</access-date>
        <comment>Use the Activity app on your Apple Watch 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://support.apple.com/en-gb/HT204517">https://support.apple.com/en-gb/HT204517</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sCO2larC"/></comment> </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wallen</surname>
            <given-names>MP</given-names>
          </name>
          <name name-style="western">
            <surname>Gomersall</surname>
            <given-names>SR</given-names>
          </name>
          <name name-style="western">
            <surname>Keating</surname>
            <given-names>SE</given-names>
          </name>
          <name name-style="western">
            <surname>Wisløff</surname>
            <given-names>U</given-names>
          </name>
          <name name-style="western">
            <surname>Coombes</surname>
            <given-names>JS</given-names>
          </name>
        </person-group>
        <article-title>Accuracy of heart rate watches: implications for weight management</article-title>
        <source>PLoS One</source>  
        <year>2016</year>  
        <volume>11</volume>  
        <issue>5</issue>  
        <fpage>e0154420</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://dx.plos.org/10.1371/journal.pone.0154420"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1371/journal.pone.0154420</pub-id>
        <pub-id pub-id-type="medline">27232714</pub-id>
        <pub-id pub-id-type="pii">PONE-D-15-55600</pub-id>
        <pub-id pub-id-type="pmcid">PMC4883747</pub-id></nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Norton</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Marfell-Jones</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Whittingham</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kerr</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Carter</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Saddington</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Gore</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <person-group person-group-type="editor">
          <name name-style="western">
            <surname>Gore</surname>
            <given-names>CJ</given-names>
          </name>
        </person-group>
        <article-title>Anthropometric assessment protocols</article-title>
        <source>Physiological Tests for Elite Athletes</source>  
        <year>2000</year>  
        <publisher-loc>Champaign, IL</publisher-loc>
        <publisher-name>Human Kinetics</publisher-name></nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Miller</surname>
            <given-names>WM</given-names>
          </name>
          <name name-style="western">
            <surname>Spring</surname>
            <given-names>TJ</given-names>
          </name>
          <name name-style="western">
            <surname>Zalesin</surname>
            <given-names>KC</given-names>
          </name>
          <name name-style="western">
            <surname>Kaeding</surname>
            <given-names>KR</given-names>
          </name>
          <name name-style="western">
            <surname>Nori</surname>
            <given-names>JKE</given-names>
          </name>
          <name name-style="western">
            <surname>McCullough</surname>
            <given-names>PA</given-names>
          </name>
          <name name-style="western">
            <surname>Franklin</surname>
            <given-names>BA</given-names>
          </name>
        </person-group>
        <article-title>Lower than predicted resting metabolic rate is associated with severely impaired cardiorespiratory fitness in obese individuals</article-title>
        <source>Obesity (Silver Spring)</source>  
        <year>2012</year>  
        <month>03</month>  
        <volume>20</volume>  
        <issue>3</issue>  
        <fpage>505</fpage>  
        <lpage>11</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://dx.doi.org/10.1038/oby.2011.262"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1038/oby.2011.262</pub-id>
        <pub-id pub-id-type="medline">21836645</pub-id>
        <pub-id pub-id-type="pii">oby2011262</pub-id></nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hopkins</surname>
            <given-names>WG</given-names>
          </name>
        </person-group>
        <source>Spreadsheets for analysis of controlled trials with adjustment for a predictor</source>  
        <year>2017</year>  
        <access-date>2017-10-30</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.sportsci.org/2017/wghxls.htm">http://www.sportsci.org/2017/wghxls.htm</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6ubRfhwBw"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hopkins</surname>
            <given-names>WG</given-names>
          </name>
        </person-group>
        <source>A New View of Statistics</source>  
        <year>2016</year>  
        <access-date>2017-07-25</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.sportsci.org/resource/stats/">http://www.sportsci.org/resource/stats/</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sDV0IzxU"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="web">
        <source>World Health Organization</source>  
        <year>2010</year>  
        <comment>Global recommendations on physical activity for health 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://apps.who.int/iris/bitstream/10665/44399/1/9789241599979_eng.pdf">http://apps.who.int/iris/bitstream/10665/44399/1/9789241599979_eng.pdf</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6sDVy83d0"/></comment> </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Thompson</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Batterham</surname>
            <given-names>AM</given-names>
          </name>
          <name name-style="western">
            <surname>Peacock</surname>
            <given-names>OJ</given-names>
          </name>
          <name name-style="western">
            <surname>Western</surname>
            <given-names>MJ</given-names>
          </name>
          <name name-style="western">
            <surname>Booso</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Feedback from physical activity monitors is not compatible with current recommendations: a recalibration study</article-title>
        <source>Prev Med</source>  
        <year>2016</year>  
        <month>10</month>  
        <volume>91</volume>  
        <fpage>389</fpage>  
        <lpage>394</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(16)30142-6"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.ypmed.2016.06.017</pub-id>
        <pub-id pub-id-type="medline">27330025</pub-id>
        <pub-id pub-id-type="pii">S0091-7435(16)30142-6</pub-id>
        <pub-id pub-id-type="pmcid">PMC5061550</pub-id></nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gomersall</surname>
            <given-names>SR</given-names>
          </name>
          <name name-style="western">
            <surname>Ng</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Burton</surname>
            <given-names>NW</given-names>
          </name>
          <name name-style="western">
            <surname>Pavey</surname>
            <given-names>TG</given-names>
          </name>
          <name name-style="western">
            <surname>Gilson</surname>
            <given-names>ND</given-names>
          </name>
          <name name-style="western">
            <surname>Brown</surname>
            <given-names>WJ</given-names>
          </name>
        </person-group>
        <article-title>Estimating physical activity and sedentary behavior in a free-living context: a pragmatic comparison of consumer-based activity trackers and ActiGraph accelerometry</article-title>
        <source>J Med Internet Res</source>  
        <year>2016</year>  
        <month>09</month>  
        <day>07</day>  
        <volume>18</volume>  
        <issue>9</issue>  
        <fpage>e239</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2016/9/e239/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.5531</pub-id>
        <pub-id pub-id-type="medline">27604226</pub-id>
        <pub-id pub-id-type="pii">v18i9e239</pub-id>
        <pub-id pub-id-type="pmcid">PMC5031913</pub-id></nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Sushames</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Edwards</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Thompson</surname>
            <given-names>F</given-names>
          </name>
          <name name-style="western">
            <surname>McDermott</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Gebel</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Validity and reliability of Fitbit Flex for step count, moderate to vigorous physical activity and activity energy expenditure</article-title>
        <source>PLoS One</source>  
        <year>2016</year>  
        <volume>11</volume>  
        <issue>9</issue>  
        <fpage>e0161224</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://dx.plos.org/10.1371/journal.pone.0161224"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1371/journal.pone.0161224</pub-id>
        <pub-id pub-id-type="medline">27589592</pub-id>
        <pub-id pub-id-type="pii">PONE-D-15-42907</pub-id>
        <pub-id pub-id-type="pmcid">PMC5010194</pub-id></nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>MAF</given-names>
          </name>
        </person-group>
        <article-title>Exercise comes of age: rationale and recommendations for a geriatric exercise prescription</article-title>
        <source>J Gerontol A Biol Sci Med Sci</source>  
        <year>2002</year>  
        <month>05</month>  
        <volume>57</volume>  
        <issue>5</issue>  
        <fpage>M262</fpage>  
        <lpage>82</lpage>  
        <pub-id pub-id-type="medline">11983720</pub-id></nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Weaving</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Marshall</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Earle</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Nevill</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Abt</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Combining internal- and external-training-load measures in professional rugby league</article-title>
        <source>Int J Sports Physiol Perform</source>  
        <year>2014</year>  
        <month>11</month>  
        <volume>9</volume>  
        <issue>6</issue>  
        <fpage>905</fpage>  
        <lpage>12</lpage>  
        <pub-id pub-id-type="doi">10.1123/ijspp.2013-0444</pub-id>
        <pub-id pub-id-type="medline">24589469</pub-id>
        <pub-id pub-id-type="pii">2013-0444</pub-id></nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Abt</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Bray</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Benson</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>The validity and inter-device variability of the Apple Watch for measuring maximal heart rate</article-title>
        <source>J Sports Sci</source>  
        <year>2017</year>  
        <month>11</month>  
        <day>01</day>  
        <fpage>1</fpage>  
        <lpage>6</lpage>  
        <pub-id pub-id-type="doi">10.1080/02640414.2017.1397282</pub-id>
        <pub-id pub-id-type="medline">29090987</pub-id></nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Soligard</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Schwellnus</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Alonso</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Bahr</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Clarsen</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Dijkstra</surname>
            <given-names>HP</given-names>
          </name>
          <name name-style="western">
            <surname>Gabbett</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Gleeson</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Hägglund</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Hutchinson</surname>
            <given-names>MR</given-names>
          </name>
          <name name-style="western">
            <surname>Janse</surname>
            <given-names>VRC</given-names>
          </name>
          <name name-style="western">
            <surname>Khan</surname>
            <given-names>KM</given-names>
          </name>
          <name name-style="western">
            <surname>Meeusen</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Orchard</surname>
            <given-names>JW</given-names>
          </name>
          <name name-style="western">
            <surname>Pluim</surname>
            <given-names>BM</given-names>
          </name>
          <name name-style="western">
            <surname>Raftery</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Budgett</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Engebretsen</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <article-title>How much is too much? (Part 1) International Olympic Committee consensus statement on load in sport and risk of injury</article-title>
        <source>Br J Sports Med</source>  
        <year>2016</year>  
        <month>09</month>  
        <volume>50</volume>  
        <issue>17</issue>  
        <fpage>1030</fpage>  
        <lpage>41</lpage>  
        <pub-id pub-id-type="doi">10.1136/bjsports-2016-096581</pub-id>
        <pub-id pub-id-type="medline">27535989</pub-id>
        <pub-id pub-id-type="pii">50/17/1030</pub-id></nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hamine</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Gerth-Guyette</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Faulx</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Green</surname>
            <given-names>BB</given-names>
          </name>
          <name name-style="western">
            <surname>Ginsburg</surname>
            <given-names>AS</given-names>
          </name>
        </person-group>
        <article-title>Impact of mHealth chronic disease management on treatment adherence and patient outcomes: a systematic review</article-title>
        <source>J Med Internet Res</source>  
        <year>2015</year>  
        <volume>17</volume>  
        <issue>2</issue>  
        <fpage>e52</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2015/2/e52/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.3951</pub-id>
        <pub-id pub-id-type="medline">25803266</pub-id>
        <pub-id pub-id-type="pii">v17i2e52</pub-id>
        <pub-id pub-id-type="pmcid">PMC4376208</pub-id></nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Barnes</surname>
            <given-names>KR</given-names>
          </name>
          <name name-style="western">
            <surname>Kilding</surname>
            <given-names>AE</given-names>
          </name>
        </person-group>
        <article-title>Strategies to improve running economy</article-title>
        <source>Sports Med</source>  
        <year>2015</year>  
        <month>01</month>  
        <volume>45</volume>  
        <issue>1</issue>  
        <fpage>37</fpage>  
        <lpage>56</lpage>  
        <pub-id pub-id-type="doi">10.1007/s40279-014-0246-y</pub-id>
        <pub-id pub-id-type="medline">25164465</pub-id></nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bassett</surname>
            <given-names>DR</given-names>
          </name>
          <name name-style="western">
            <surname>Howley</surname>
            <given-names>ET</given-names>
          </name>
        </person-group>
        <article-title>Limiting factors for maximum oxygen uptake and determinants of endurance performance</article-title>
        <source>Med Sci Sports Exerc</source>  
        <year>2000</year>  
        <month>01</month>  
        <volume>32</volume>  
        <issue>1</issue>  
        <fpage>70</fpage>  
        <lpage>84</lpage>  
        <pub-id pub-id-type="medline">10647532</pub-id></nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Martin</surname>
            <given-names>PE</given-names>
          </name>
          <name name-style="western">
            <surname>Rothstein</surname>
            <given-names>DE</given-names>
          </name>
          <name name-style="western">
            <surname>Larish</surname>
            <given-names>DD</given-names>
          </name>
        </person-group>
        <article-title>Effects of age and physical activity status on the speed-aerobic demand relationship of walking</article-title>
        <source>J Appl Physiol (1985)</source>  
        <year>1992</year>  
        <month>07</month>  
        <volume>73</volume>  
        <issue>1</issue>  
        <fpage>200</fpage>  
        <lpage>6</lpage>  
        <pub-id pub-id-type="doi">10.1152/jappl.1992.73.1.200</pub-id>
        <pub-id pub-id-type="medline">1506370</pub-id></nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
