TY  - JOUR
AU  - Khusial, Rishi Jayant
AU  - Sont, Jacob K
AU  - Usmani, Omar S
AU  - Bonini, Matteo
AU  - Chung, Kian Fan
AU  - Fowler, Stephen James
AU  - Honkoop, Persijn J
PY  - 2024
DA  - 2024/12/11
TI  - The Effect of Inhaled Beta-2 Agonists on Heart Rate in Patients With Asthma: Sensor-Based Observational Study
JO  - JMIR Cardio
SP  - e56848
VL  - 8
KW  - asthma
KW  - mHealth
KW  - side effects
KW  - beta-2 agonists
KW  - inhaler medication
KW  - heart rate
KW  - sensor
KW  - observational study
KW  - asthma management
KW  - cardiac cells
KW  - monitoring
KW  - Fitbit
KW  - inhaler
AB  - Background: Beta-2 agonists play an important role in the management of asthma. Inhaled long-acting beta-2 agonists (LABAs) and short-acting beta-2 agonists (SABAs) cause bronchodilation by stimulating adrenoceptors. These receptors are also present in cardiac cells and, as a side effect, could also be stimulated by inhaled beta-2 agonists. Objective: This study aims to assess the effect of beta-2 agonists on heart rate (HR). Methods: The data were retrieved from an observational study, the myAirCoach Quantification Campaign. Beta-2 agonist use was registered by self-reported monthly questionnaires and by smart inhalers. HR was monitored continuously with the Fitbit Charge HR tracker (Fitbit Inc). Patients (aged 18 years and older) were recruited if they had uncontrolled asthma and used inhalation medication. Our primary outcome was the difference in HR between LABA and non-LABA users. Secondary outcomes were the difference in HR on days SABAs were used compared to days SABAs were not used and an assessment of the timing of inhaler use during the day. Results: Patients using LABA did not have a clinically relevant higher HR (average 0.8 beats per minute difference) during the day. Around the moment of SABA inhalation itself, the HR does increase steeply, and it takes 138 minutes before it returns to the normal range. Conclusions: This study indicates that LABAs do not have a clinically relevant effect on HR. SABAs are instead associated with a short-term HR increase. Trial Registration: ClinicalTrials.gov NCT02774772; https://clinicaltrials.gov/study/NCT02774772 
SN  - 2561-1011
UR  - https://cardio.jmir.org/2024/1/e56848
UR  - https://doi.org/10.2196/56848
DO  - 10.2196/56848
ID  - info:doi/10.2196/56848
ER  -