Published on in Vol 2, No 1 (2018): Jan-Jun

Smartphone Apps Using Photoplethysmography for Heart Rate Monitoring: Meta-Analysis

Smartphone Apps Using Photoplethysmography for Heart Rate Monitoring: Meta-Analysis

Smartphone Apps Using Photoplethysmography for Heart Rate Monitoring: Meta-Analysis


1University Hospital Ghent, Ghent, Belgium

2Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

3Wageningen University, Biometris, Wageningen, Netherlands

4StatUa Center for Statistics, University of Antwerp, Antwerp, Belgium

5Department of Cardiology, Antwerp University Hospital, Edegem, Belgium

6Department of Cardiology, University of Antwerp, Antwerp, Belgium

Corresponding Author:

Benjamin De Ridder, BN, MS

University Hospital Ghent

De Pintelaan 185

Ghent, 9000


Phone: 32 472260561


Background: Smartphone ownership is rising at a stunning rate. Moreover, smartphones prove to be suitable for use in health care due to their availability, portability, user-friendliness, relatively low price, wireless connectivity, far-reaching computing capabilities, and comprehensive memory. To measure vital signs, smartphones are often connected to a mobile sensor or a medical device. However, by using the white light-emitting diode as light source and the phone camera as photodetector, a smartphone could be used to perform photoplethysmography (PPG), enabling the assessment of vital signs.

Objective: The objective of this meta-analysis was to evaluate the available evidence on the use of smartphone apps to measure heart rate by performing PPG in comparison with a validated method.

Methods: PubMed and ISI Web of Knowledge were searched for relevant studies published between January 1, 2009 and December 7, 2016. The reference lists of included studies were hand-searched to find additional eligible studies. Critical Appraisal Skills Programme (CASP) Diagnostic Test Study checklist and some extra items were used for quality assessment. A fixed effects model of the mean difference and a random effects model of Pearson correlation coefficient were applied to pool the outcomes of the studies.

Results: In total, 14 studies were included. The pooled result showed no significant difference between heart rate measurements with a smartphone and a validated method (mean difference −0.32; 99% CI −1.24 to 0.60; P=.37). In adults, the Pearson correlation coefficient of the relation between heart rate measurement with a smartphone and a validated method was always ≥.90. In children, the results varied depending on measuring point and heart rate. The pooled result showed a strong correlation that was significant (correlation coefficient .951; 95% CI 0.906-0.975; P<.001). The reported limits of agreement showed good agreement between a smartphone and a validated method. There was a moderately strong significant negative correlation between the year of publication of the included studies and the mean difference (r=−.69; P<.001).

Conclusions: Smartphone apps measuring heart rate by performing PPG appear to agree with a validated method in an adult population during resting sinus rhythm. In a pediatric population, the use of these apps is currently not validated.

JMIR Cardio 2018;2(1):e4




Smartphone ownership rises year by year. Advanced economies still have the highest smartphone ownership rates. Smartphone ownership in countries with an emerging and developing economy, however, is rising at a stunning rate [1].

Due to their availability, portability, user-friendliness, relatively low price, wireless connectivity, far-reaching computing capabilities, and comprehensive memory, smartphones prove to be suitable for use in health care [2-4]. A wide offer of health and medical applications exist from diagnostic tools over professional education to apps supporting patients and health consumers [3,5]. In the field of cardiological literature, there has been a growing interest in mobile apps since 2003 [6].

Measuring Vital Signs

Most of the studies focus on measuring vital signs using a smartphone. To this end, smartphones are mostly connected to a mobile sensor or medical device [6]. A majority of smartphones receive the information through built-in Bluetooth technology. They often process the information before transferring data to a server. At server level, the information can be further processed, organized, and analyzed to create a report for the user [2,4]. Hence, this type of monitoring requires several sensors or a separate device, which can be quite expensive [4].Another way to measure heart rate is by utilizing a pulse oximeter using photoplethysmography (PPG). In total, 2 key components are essential to create a PPG waveform: a light source to illuminate the subcutaneous tissue and a photodetector to detect the changes in light intensity [7]. Jonathan en Leahy demonstrated that a smartphone could be used to perform PPG. The white light-emitting diode can be used as light source and the phone camera as photodetector. The 2 components should be positioned next to each other for reflection mode PPG; in comparison, in transmission mode PPG, the photodetector is placed opposite to the light source [8].

The PPG waveform is influenced by many factors enabling the assessment of vital signs, for example, oxygen saturation, blood pressure, respiratory rate, and heart rate. Promising results show the ability to screen for pathologies related to peripheral vascular disease [7-9]. The purpose of this review was to analyze the available evidence on measuring heart rate by performing PPG using smartphones in comparison with a validated method.

Literature Search and Selection Criteria

We conducted a systematic literature search of PubMed and ISI Web of Knowledge from January 1, 2009 to December 7, 2016, with the following search key: (smartphone* OR phone* OR ((Applic* OR App*) AND (mobile OR electronic OR software)) OR PPG OR Photoplethysmograph* OR Rheograph*) AND (Electrocardiogr* OR ECG OR EKG or Oximet*) AND ((rate* AND (heart OR pulse)) OR tachycardia* OR beat* OR complex* OR arrhythmia* OR fibrillation*). Only papers in English, German, French, or Dutch were included. The reference lists of included studies were hand-searched to find additional eligible studies.

Studies were included if the measurement of heart rate was conducted with the photo camera of a smartphone by PPG; the measurements were made at a finger, toe, or earlobe; the measurements of the smartphone were compared with an electrocardiogram (ECG), a pulse oximeter, or another validated method to determine heart rate. Studies were excluded if the measurement was conducted with a mobile sensor or medical device connected to a smartphone; the paper did not have heart rate as one of the outcomes; no abstract or full text was available.

Data Extraction and Outcome Measures

Data were extracted by the first author and reviewed by all authors.

Following are study and intervention characteristics extracted from the included studies: first author, study country, study year, sample size, baseline characteristics of participants, age of the participants (mean or range), type of smartphone used, control instrument, duration and conditions of the measurement, and primary outcome measures. The primary outcome measures were the mean difference between heart rate measured by a smartphone and a validated method, the correlation coefficient of the relation between heart rate measurements made by both methods, and the 95% limits of agreement derived from a Bland-Altman plot.

Overall, 1 author was contacted to receive missing data about the heart rate measurements; 2 authors were contacted because of a lack of clarity about the data; and 7 authors were contacted to get access to the full text of the paper; but 2 authors failed to respond to that last request.

Study Quality

Study quality was appraised using the Critical Appraisal Skills Programme (CASP) Diagnostic Test Study checklist [10]. In addition, the included studies were evaluated by extra considerations described in the study of Hanneman [11]. The first was an appraisal tool developed for diagnostic studies. The checklist covered 3 sections: the validity of the results, the actual results, and the utility of the results. With the exception of the questions focusing on the actual results, the topics described were relevant for a method comparison study design. The 9 remaining questions were answered by “yes,” “can’t tell,” or “no.” One question was adapted so that “yes” always indicated a positive answer and “no” a negative answer. “Can’t tell” was answered when there was not enough information found in the study to answer the question. The checklist gave an indication of the quality per section and did not focus on a total score. The latter focused on specific considerations for a method comparison study design. The considerations were converted in 5 questions. These questions were also answered by “yes,” “can’t tell,” or “no.”

The quality assessment was performed by the first author and reviewed by the other authors.

Statistical Methods

In total, 3 different statistics were described, and 2 of them were used for estimation of the pooled result. The first was the mean difference between heart rate measured by a smartphone and a validated method. In case of absence of a mean value and standard deviation in the original paper, it was calculated manually where possible on the basis of the original data.

The second was the Pearson correlation coefficient calculated from the relation between heart rate measured by a smartphone and a validated method. The P value was calculated manually out of the correlation coefficient and sample size if not described in the original paper.

The third were the 95% limits of agreement. They were derived from a Bland-Altman plot. Lower and upper limits were calculated starting from the mean difference by respectively subtracting and adding up the standard deviation of the mean difference between both methods, multiplied by a factor of 1.96. In 2 studies, they were calculated manually starting from the mean difference and the described limit of agreement.

The pooled result was estimated using a fixed- or random-effects model. Statistical heterogeneity was tested using the chi-squared test where a significant result indicated statistical heterogeneity. To quantify inconsistency, the I² of Higgins was used. In case of statistical heterogeneity, a random-effects model was used for pooling the results. Due to the small number of included studies, it was not possible to explore heterogeneity by subgroup analysis or meta-regression [12].

Pearson correlation was used to analyze the relation between different variables (publication year, mean heart rate, and sample size) and the mean difference. The scatter plots of these correlations were drawn.

Statistical analyses were performed using Review Manager Version 5.3 (The Cochrane collaboration, Copenhagen: Denmark: The Nordic Cochrane Centre, 2014), MedCalc 17.4 (MedCalc Software, Ostend: Belgium, 2017), and Microsoft Office Excel 2007 (Microsoft, 2007). Statistical significance level was set at 5%, except for mean difference where statistical significance level was set at 1%.

Study Identification and Selection

Figure 1 shows a diagram of the search and selection strategy. Initially, 1637 studies were found in 2 databases. First, 312 duplicates—identical studies found in both databases—were removed, followed by 1245 studies on the basis of an irrelevant title. The abstract of the remaining 80 studies was screened of which 55 were excluded for not fulfilling the selection criteria [4,13-66]. The 25 remaining studies were reviewed by reading the full text [8,67-90]. An additional 10 studies were excluded for not fulfilling the selection criteria [8,67,71,72,74,76,81,83,84,86]. For 2 studies, the full text could not be retrieved [69,77]. One paper was added after hand-searching the reference list of the included studies [91]. A total of 14 studies was used for this review and meta-analysis [68,70,73,75,78-80,82,85,87-91].

Study Characteristics

Table 1 presents the characteristics of the included studies. In total, 5 studies reported findings on North American participants [68,73,85,89,90], 6 on Western European participants [70,78-80,87,91], and 3 on East Asian participants [75,82,88]. The oldest studies dated from 2010 and the most recent from 2016. Sample sizes varied from 1 to 68, with a median of 24. In total, 8 studies studied an adult population [70,73,78,80,82,85,87,91] and 2 an infant population [75,90], and 4 studies did not mention the age of the participants [68,79,88,89]. In 9 studies, the reference instrument was an ECG [68,70,75,78,79,82,85,89,90]; in 4 studies, a pulse oximeter [80,87,88,91]; and in 1 study, both [73]. The duration of the measurement varied between 10 s and 5 min. Of the selected studies, 2 did not mention the duration of the measurement [89,90]. A total of 5 studies tried to evoke variations in heart rate [68,73,78,82,91], 2 studies controlled the breathing of the participants during measurement [85,89], 1 paper made measurements in different lighting conditions [87], and 1 paper made measurements during different heart rhythms [90]. Overall, 8 studies studied another outcome besides heart rate, namely heart rate variability parameters [68,78,79], other vital parameters [85,89], and other outcomes [70,82,88].

Study Quality

Table 2 presents the quality assessment of the included studies. The quality assessment questions are listed in Textbox 1. All studies had a clear study question and compared the measurements of the smartphone with an appropriate reference standard. Due to the type of test, it was not possible that the measurement of the reference standard influenced the measurement of the smartphone. Also, both methods did measure the same outcome simultaneously. Totally, 5 studies made a clear description of the disease status of the participants [70,73,80,82,90]. Just over half of the studies described the methods for performing the test in sufficient detail [68,70,73,75,78,80,82,85]. Half of the studies provided enough information about the participants to conclude that the results may be applicable to the population of interest [73,75,78,80,82,85,90]. All studies had the same relevant outcome and performed their measurements in a similar way. All but one [82] studies acknowledged that the sample size was small. In 6 studies, the authors made an effort to measure a wide range of the possible physiological values of heart rate [68,73,78,82,90,91]. Only 3 studies used a cutoff value for the clinical acceptable difference between the measurements made by the 2 methods [73,75,80].

Primary Outcome: Heart Rate

The mean difference between heart rate measured by a smartphone and a validated method was analyzed in a fixed-effects model (Figure 2). This statistic was reported in 7 studies [68,73,80,82,88,89,91]. For 2 studies, it was calculated manually out of the original data [85,87]. In 2 studies, the mean difference was consistently positive [82,89]; and in 5 studies, negative [73,80,85,87,88]. In 2 studies, the mean difference was negative, except for 1 condition where there was no difference [68] or the mean difference was positive [91]. The pooled estimate of the 9 included studies suggested that there is no difference between both methods (mean difference −0.32; 99% CI −1.24 to 0.60; P=.37). No statistical heterogeneity was observed among the studies (I²=0%; P>.99).

Table 3 shows the correlation coefficient of the relation between heart rate measurement with a smartphone and a validated reference method. This statistic was reported in 9 studies [68,70,73,75,78-80,82,90]. Previous research stated that the correlation between 2 methods that measure heart rate should be ≥.90 to be considered as valid [92]. In 7 studies, the correlation coefficient was always ≥.90 and the result was statistical significant [68,70,73,78-80,82]. The 2 studies that studied a pediatric population showed more variation in their results. In 1 , the correlation coefficients were remarkably lower during periods of tachycardia, namely .56 and −.43 [90] and not statistical significant for the latter. In 1 paper, the correlation coefficient was only ≥.90 in 2 of the 4 apps. In 1 of these 2 apps, this was just the case for measurements at the earlobe [75].

Figure 1. Search and selection strategy.
View this figure
Table 1. Characteristics of included studies.
Author, year, and countrySample size and age (range or mean [SD])SmartphoneControlDuration and conditions measurementOutcome measure
Bolkhovsky et al, 2012, United States [68]22 subjects, age not specifiedMotorola Droid, iPhone 4SECGa2 × 2 min: supine and sitting up in tilt position (iPhone 4S, n=9); 2 × 5 min: supine and sitting up in tilt position (Motorola Droid, n=13)Heart rate, heart rate variability
Drijkoningen et al, 2014, Belgium [70]28 adults with sinus rhythm during electrophysiological examination, age not specifiedSamsung Galaxy S4ECG60 sHeart rate, premature atrial ectopic beats identification
Gregoski et al, 2012, United States [73]14 adults, 18-59 yearsMotorola DroidECG, pulse oximeter3 × 5 min: sitting, at rest, reading, and playing a video gameHeart rate
Ho et al, 2014, Taiwan [75]40 children undergoing ECG monitoring, 3 days to 15 yearsiPhone 4SECG3 × 20 s at finger (or toe) and earlobeHeart rate
Koenig et al, 2016, Germany [78]68 adults (45 patients from a cardiologic outpatient ambulance and 23 healthy controls), 51.7 (18.83) yearsiPhone 4SECG5 min: at rest 2 min: after 3 min of physical exercise (only controls)Heart rate, heart rate variability
Kurylyak et al, 2012, Italy [91]10 adults, 26-60 yearsHTC HD2, iPhone 4, Nokia 5800, Samsung Galaxy S i9000Pulse oximeter2 × 60 s (per smartphone): at rest and after 60 s squattingHeart rate
Lagido et al, 2014, Portugal [79]43 heart failure patients, age not specifiedSony Xperia SECGAt restHeart rate, heart rate variability
Losa-Iglesias et al, 2016, Spain [80]46 healthy adults, 39.3 (7.35) yearsSamsung Galaxy NoteRadial pulse, pulse oximeter3 × 10-30 s: at rest (resting 10 min before measurements)Heart rate
Matsumara et al, 2013, Japan [82]12 students, 21-24 yearsiPhone 4SECG3 × 3 min: at rest (resting 7 min before measurement), during mental arithmetic, and during mirror tracingHeart rate, normalize pulse volume
Nam et al, 2016, United States [85]11 healthy nonsmoking adults, 20-40 yearsHTC One M8ECG3 × 2 min: breathing at frequencies from 0.1 to 0.5 Hz at increments of 0.1 Hz, breathing at 1 Hz and spontaneous breathingHeart rate and breathing rate
Pelegris et al, 2010, UK [87]50 adults, 21-55 yearsHTC TattooPulse oximeter2 × 9 s: well-lit room and average lit roomHeart rate
Po et al, 2015, China [88]10 subjects, age not specifiedSamsung Galaxy Nexus, LG Optimus P920, Samsung Galaxy S2, Samsung Galaxy Tablet 7.0, Motorala AtrixPulse oximeter1 × 20 sHeart rate and root mean square distortion of heart rate
Scully et al, 2012, United States [89]1 subject, age not specifiedMotorola DroidECG1 × ?: spontaneous breathing
3 × 2 min: breathing at 0.2, 0.3, and 0.4 Hz
Heart rate, respiration rate, oxygen saturation
Wackel et al, 2014, United States [90]26 children undergoing an electrophysiology study under general anesthesia, 5-17 yearsiPhone 5ECG2 × ?: during baseline heart rate (34 measurements in 17 children)
2 × ?: during sustained supraventricular tachycardia (38 measurements during 21 supraventricular tachycardia in 18 children)
Heart rate

aECG: electrocardiogram.

Table 2. Study quality according to Critical Appraisal Skills Programme Diagnostic Test study checklist and extra considerations. Y indicates yes; N indicates no; and C indicates can’t tell.
StudyValidity of resultsUtility of resultsExtra considerations

Bolkhovsky et alYYYYNYCYYYYNYN
Drijkoningen et alYYYYYYCYYYYNNN
Losa-Iglesias et alYYYYYYYYYYYNNY
Quality assessment questions.

Critical Appraisal Skills Programme Diagnostic study checklist

  • Validity of results
    • Was there a clear question for the study to address?
    • Was there a comparison with an appropriate reference standard?
    • Did all patients get the diagnostic test and reference standard?
    • Is there no possibility that the results of the test have been influenced by the results of the reference standard?
    • Is the disease status of the tested population clearly described?
    • Were the methods for performing the test described in sufficient detail?
  • Utility of results
    • Can the results be applied to your patients/the population of interest?
    • Can the test be applied to your patient or population of interest?
    • Were all outcomes important to the individual or population considered?

Extra considerations

  • Do both methods measure the same outcome?
  • Do both methods measure the outcome simultaneous?
  • Did the investigators motivate their choice for the sample size?
  • Did the investigators test both methods in different conditions to simulate the possible physiological range of values?
  • Did the investigators set up cutoff values for the clinical acceptable difference between both methods?
Textbox 1. Quality assessment questions.
Figure 2. Forest plot for the meta-analysis of mean difference.
View this figure
Table 3. Results for heart rate: Pearson correlation coefficient.
StudyConditions (sample size)rar.90?P valueb
Bolkhovsky et aliPhone supine (9)>.99Yes<.001c

iPhone tilt (9)>.99Yes<.001c

Droid supine (13).98Yes<.001c

Droid tilt (13)>.99Yes<.001c
Drijkoningen et alNot specified (28).98Yes<.001
Gregoski et alAt rest (14).99Yes<.001c

Reading (14).99Yes<.001c

Video game (14).99Yes<.001
Ho et alApp A finger (40).81No<.001

App A earlobe (40).91Yes<.001

App B finger (40).75No<.001

App B earlobe (40).76No<.001

App C finger (40).27No.10

App C earlobe (40).46No.003

App D finger (40).90Yes<.001

App D earlobe (40).98Yes<.001
Koenig et al80 randomly chosen intervals at rest or after exercise (68)>.99Yes<.001c
Lagido et alAt rest (43).94Yes<.001c
Losa-Iglesias et alSitting up (46).95Yes<.001
Matsumura et alAll conditions (12).99Yes<.001c
Wackel et alApp 1 sinus rhythm (17).99Yes<.001c

App 1 tachycardia (10 succeeded attempts).56No.01c

App 2 sinus rhythm (17).99Yes<.001c

App 2 tachycardia (5 succeeded attempts)−.43No.09c

ar value of Pearson correlation coefficient.

bP value calculated with Pearson correlation.

cData based on own calculations.

The correlation between heart rate measurements made by a smartphone and a control instrument was analyzed in a random-effects model (Figure 3). The pooled correlation coefficient made the assumption that on average measurements made by a smartphone are highly correlated to those made by a control instrument (correlation coefficient .951; 95% CI 0.906-0.975; P<.001). Of note, statistical heterogeneity was high (I²=93.8%; P<.001), indicating variability across the studies.

Table 4 shows the 95% limits of agreement for the MD between measurements with a smartphone and a validated method. This statistic was reported in 4 studies [80,82,85,88]. For 2 studies, it was calculated manually [68,73]. In all studies, the limits of agreement did not exceed 10 beats per minute.

Correlations With the Mean Difference

The correlation between the mean heart rate measured by a validated method, the sample size of the included studies, and the year of publication of the included studies and the mean difference was analyzed in Figures 4-6, respectively. Correlations between the mean difference and the mean heart rate measured by a validated instrument (r=.13) and sample size (r=−.06) were not significant. However, data showed a moderately strong correlation between the year of publication and the mean difference (r=−.69; P<.001).

Figure 3. Forest plot for the meta-analysis of Pearson correlation coefficient.
View this figure
Table 4. Results for heart rate: 95% limits of agreement.
StudyConditions (sample size)95% LOAa (BPMb), control—smartphone
Bolkhovsky et aliPhone supine (9)−0.4 to 0.2c

iPhone tilt (9)−0.3 to 0.3c

Droid supine (13)−3.4 to 3.0c

Droid tilt (13)−1.7 to 1.1c
Gregoski et alVideo game (14)−3.9 to 3.7c
Loso-Iglesias et alSitting up (46)−8.5 to 2.0
Matsumura et alAll conditions (12)−1.0 to 1.4
Nam et alAt rest, sitting up (11)−5.6 to 5.5
Pot et alAverage all smartphones (10)−4.1 to 1.2

aLOA: limits of agreement.

bBPM: beats per minute.

cData based on own calculations.

Figure 4. Scatter plot comparing correlation between mean heart rate measured by control and mean difference.
View this figure
Figure 5. Scatter plot comparing correlation between sample size and mean difference.
View this figure
Figure 6. Scatter plot comparing correlation between year of publication and mean difference.
View this figure

Principal Findings

The meta-analysis of the mean difference showed no statistical difference between the measurement of heart rate by a smartphone and a validated method (mean difference −0.32; 99% CI −1.24 to 0.60; P=.37). The pooled correlation coefficient between heart rate measurement by a smartphone and a validated method was more than .90 and statistically significant (correlation coefficient .951; 95% CI 0.906-0.975; P<.001). Reported 95% limits of agreement had a narrow range and therefore showed good agreement between a smartphone and a validated method. These results suggest that a smartphone app deriving heart rate from a PPG signal could be used as an alternative for already validated methods such as an ECG or pulse oximeter in an adult population in resting sinus rhythm. However, the significant negative correlation between the year of publication of the included studies and the mean difference (r=−.69; P<.001) suggests that smartphone technology for measuring heart rate did not improve over time. There was no significant correlation between the mean difference and the mean heart rate measured by a validated method (r=.13; P=.54) or the sample size of the included studies (r=−.06; P=.77), which suggests that smartphone results are consistent for heart rate measurements between 60 and 100 beats per minute.


First, the results of the studies in a pediatric population showed that it is not advisable yet to use these apps in children. A possible cause is that because of the smaller size of children’s fingertips, the pulsatile flow may be less consistently detected. The use of the earlobe as a measuring point may present a possible solution. Children may also have difficulties in containing the appropriate pressure on the camera lens and keeping their finger motionless to make a good measurement [73,75,90].

A second issue is heart rate measurement during periods of arrhythmia [4]. The low correlation between measurements with a smartphone and a validated method during periods of supraventricular tachycardia in children suggests that current apps do not give adequate results during periods of extremely high heart rates [90]. Moreover, the smartphone apps in the studies used PPG, calculating the heart rate on basis of the pulse rate. Hence, the results may not be accurate enough during periods of arrhythmia with variations in pulse rate and amplitude due to heart rhythm irregularities [4,82]. A solution is to improve sensitivity and specificity of the apps for deviant heart rhythms depending on the purpose of the apps [62].

Third, previous research stated that heart rate measurement can be susceptible to environmental or human factors such as ambient light, motion [4,93], or skin color [7]. In total, 3 studies reported about lighting conditions [87,88,91]. In these studies, ambient light did not seem to have an influence, but it should still be taken into account. On the basis of this review, it is not possible to say something about the influence of motion, as none of the included studies tested whether accurate pulse rate is measurable by the smartphone apps during exercise. However, several studies do mention this limitation in their discussion. Wearable devices using PPG possibly provide better results during exercise [94]. Only 1 paper mentioned to have included participants with a variety of skin colors but did not make a comparison between different skin types [73]. Hereby, we cannot come to a conclusion about the topic in this review. When using PPG to measure heart rate, it should be taken into account to use a proper light wavelength that gives equal results for people with different skin types [95].

Fourth, it was remarkable that in the included studies the mean difference became more and more negative over time. A plausible explanation is that every paper focuses on (a) certain type(s) of smartphone model(s) or app(s). Consequently, the results cannot be automatically projected to other smartphones and apps [4]. The use of certain smartphones or apps could lead to better results.

Strengths and Limitations

First of all, to the best of our knowledge, this was the first systematic review and meta-analysis evaluating smartphone apps using PPG to measure heart rate. A comprehensive search strategy was used, including every paper investigating smartphone apps deriving heart rate measurement from a PPG signal. At last, there was a focus on different statistics for assessing agreement between methods.

Nevertheless, there were some limitations of the included studies. First, the methodological quality was often low, reflected by the fact that only 3 studies scored 12 or more out of 14 on the quality assessment questions [73,80,82].

Second, most of the mean heart rates that were reported lay between 70 and 80 beats per minute. As a result, it was not possible to investigate whether smartphones could be used to measure the higher physiological ranges of heart rate.

Third, only 8 of the included studies [68,70,73,78,80,82,85,88] used the most appropriate method to determine agreement between the 2 methods, the Bland-Altman plot [96,97]. Of these studies, only 2 mentioned a conclusion of the results, which were in line with the findings of the review [70,78]. A consideration about this method is that it is not easy to determine good agreement [96]. In the literature, no description was found of the maximum heart rate deviation to be clinical relevant. A deviation of under 10 beats per minute has no important clinical implications but does indicate small alterations when repeating the measures. The other methods can support the findings but have their limitations. A Pearson correlation gives information about the relation between methods, but a high correlation does not necessarily mean that the 2 methods agree [97,98]. When using a mean difference, poor agreement can be hidden by looking at the mean difference, without exploring the individual values (eg, an overestimation of high heart rates in combination with an underestimation of low heart rates will also give a mean difference of 0) [97].

A fourth and last limitation is a high statistical heterogeneity between studies on the level of correlation coefficients. This is likely attributable to clinical heterogeneity caused by differences in patient characteristics (eg, adults vs children), the conditions in which the heart rates were measured (eg, at sinus rhythm vs during a period of tachycardia), and which smartphone or app was used [12].

All these factors may influence the generalizability of the results.

In addition, there were some limitations specific to the review. The data were extracted by the first author only; however, they were thoroughly reviewed by the other authors, of which one is specialized in cardiology. In addition, 2 studies were excluded because the full text could not be retrieved [69,77]; the results described in the abstracts of those studies agreed with the pooled results, so their exclusion would probably have a minimal effect.


This meta-analysis suggests that heart rate measured by smartphone apps performing PPG agrees with a validated method in an adult population in resting sinus rhythm, provided that during measurement the measuring point was kept still and that appropriate pressure was maintained. In a pediatric population, the use of these apps can currently not be supported, especially not during periods of tachycardia. Future research with a larger and more diverse study population should be conducted. The technology should also be tested in more varied clinical situations evoking variations in normal heart rate and during arrhythmias.

Authors' Contributions

BDR made most of the contributions to conception and design, to the acquisition of data, and to analysis and interpretation of data. The other authors played an important role in acquiring missing data and revising it critically for important intellectual content. All authors reviewed and approved the data and the final text.

Conflicts of Interest

None declared.

  1. Poushter J. Pewglobal. 2016. Smartphone Ownership and Internet Usage Continues to Climb in Emerging Economies   URL: http:/​/www.​​2016/​02/​22/​smartphone-ownership-rates-skyrocket-in-many-emerging-economies-but-digital-divide-remains/​ [accessed 2017-01-06] [WebCite Cache]
  2. Baig MM, GholamHosseini H, Connolly MJ. Mobile healthcare applications: system design review, critical issues and challenges. Australas Phys Eng Sci Med 2015 Mar;38(1):23-38. [CrossRef] [Medline]
  3. Sarasohn-Kahn J. CHCF. 2010. How Smartphones Are Changing Health Care for Consumers and Providers   URL: http:/​/www.​​~/​media/​MEDIA%20LIBRARY%20Files/​PDF/​PDF%20H/​PDF%20HowSmartphonesChangingHealthCare.​pdf [accessed 2017-08-06] [WebCite Cache]
  4. Bruining N, Caiani E, Chronaki C, Guzik P, van der Velde E, Task Force of the e-Cardiology Working. Acquisition and analysis of cardiovascular signals on smartphones: potential, pitfalls and perspectives: by the Task Force of the e-Cardiology Working Group of European Society of Cardiology. Eur J Prev Cardiol 2014 Nov;21(2 Suppl):4-13. [CrossRef] [Medline]
  5. Ozdalga E, Ozdalga A, Ahuja N. The smartphone in medicine: a review of current and potential use among physicians and students. J Med Internet Res 2012;14(5):e128 [FREE Full text] [CrossRef] [Medline]
  6. Martínez-Pérez B, de la Torre-Diez I, López-Coronado M, Herreros-González J. Mobile apps in cardiology: review. JMIR Mhealth Uhealth 2013;1(2):e15 [FREE Full text] [CrossRef] [Medline]
  7. Allen J. Photoplethysmography and its application in clinical physiological measurement. Physiol Meas 2007 Mar;28(3):R1-39. [CrossRef] [Medline]
  8. Jonathan E, Leahy M. Investigating a smartphone imaging unit for photoplethysmography. Physiol Meas 2010 Nov;31(11):N79-N83. [CrossRef] [Medline]
  9. Elgendi M. On the analysis of fingertip photoplethysmogram signals. Curr Cardiol Rev 2012 Feb;8(1):14-25 [FREE Full text] [Medline]
  10. Critical Appraisal Skills Programme. 2016. 12 questions to help you make sense of a diagnostic test study   URL: [WebCite Cache]
  11. Hanneman SK. Design, analysis, and interpretation of method-comparison studies. AACN Adv Crit Care 2008;19(2):223-234 [FREE Full text] [CrossRef] [Medline]
  12. Deeks JJ, Higgins JP, Altman DG. Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JP, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. UK: Cochrane Collaboration; 2011.
  13. Weng J, Guo XM, Chen LS, Yuan ZH, Ding XR, Lei M. Study on real-time monitoring technique for cardiac arrhythmia based on smartphone. J Med Biol Eng 2013;33(4):394. [CrossRef]
  14. Waks JW, Fein AS, Das S. Wide complex tachycardia recorded with a smartphone cardiac rhythm monitor. JAMA Intern Med 2015 Mar;175(3):437-439. [CrossRef] [Medline]
  15. Tofield A. Cardiac arrhythmia challenge: a new app. Eur Heart J 2013 Nov;34(44):3392. [Medline]
  16. Tan YY, Chung WY. Mobile health-monitoring system through visible light communication. Biomed Mater Eng 2014;24(6):3529-3538. [CrossRef] [Medline]
  17. Tabing A, Harrell T, Francisco G, Romero S. Supraventricular tachycardia diagnosed by smartphone electrocardiography. J Am Coll Cardiol 2016 Apr;67(13):1237. [CrossRef]
  18. Su Y, Yin L, Al-Hakim L. Ephone: embedded cardiac care device in mobile phone. Sen Lett 2011 Oct 01;9(5):1974-1978. [CrossRef]
  19. Petersen CL, Chen TP, Ansermino JM, Dumont GA. Design and evaluation of a low-cost smartphone pulse oximeter. Sensors (Basel) 2013 Dec 06;13(12):16882-16893 [FREE Full text] [CrossRef] [Medline]
  20. Peng RC, Zhou XL, Lin WH, Zhang YT. Extraction of heart rate variability from smartphone photoplethysmograms. Comput Math Methods Med 2015;2015:516826 [FREE Full text] [CrossRef] [Medline]
  21. Oster J, Behar J, Colloca R, Li Q, Li Q, Clifford G. Open source Java-based ECG analysis software and Android app for Atrial Fibrillation screening. 2013 Presented at: Computing in Cardiology Conference (CinC); September 22-25, 2013; Zaragoza, Spain.
  22. Orchard J, Freedman SB, Lowres N, Peiris D, Neubeck L. iPhone ECG screening by practice nurses and receptionists for atrial fibrillation in general practice: the GP-SEARCH qualitative pilot study. Aust Fam Physician 2014 May;43(5):315-319 [FREE Full text] [Medline]
  23. Nyotowidjojo I, Erickson RP, Lee KS. Crowd-sourcing syncope diagnosis: mobile smartphone ECG apps. Am J Med 2016 Apr;129(4):e17-e18. [CrossRef] [Medline]
  24. Nguyen HH, Van Hare GF, Rudokas M, Bowman T, Silva JN. SPEAR trial: smartphone pediatric electrocARdiogram trial. PLoS One 2015;10(8):e0136256 [FREE Full text] [CrossRef] [Medline]
  25. Li JP, Berry D, Hayes R. A mobile ECG monitoring system with context collection. 2009 Presented at: 4th European Conference of the International Federation for Medical and Biological Engineering; November 23-27; Antwerp, Belgium p. 1222-1225. [CrossRef]
  26. Lee J, Reyes BA, McManus DD, Mathias O, Chon KH. Atrial fibrillation detection using an iPhone 4S. IEEE Trans Biomed Eng 2013 Jan;60(1):203-206. [CrossRef] [Medline]
  27. Landreani F, Martin-Yebra A, Casellato C, Frigo C, Pavan E, Migeotte P, et al. Beat-to-beat heart rate detection by smartphone's accelerometers: validation with ECG. 2016 Aug Presented at: IEEE 38th Annual International Conference of Engineering in Medicine and Biology Society (EMBC), 2016; August 16-20, 2016; Orlando, FL, USA p. 525-528. [CrossRef]
  28. Kwon S, Lee J, Chung GS, Park KS. Validation of heart rate extraction through an iPhone accelerometer. Conf Proc IEEE Eng Med Biol Soc 2011;2011:5260-5263. [CrossRef] [Medline]
  29. Kwon S, Kim H, Park KS. Validation of heart rate extraction using video imaging on a built-in camera system of a smartphone. Conf Proc IEEE Eng Med Biol Soc 2012;2012:2174-2177. [CrossRef] [Medline]
  30. Kirtava Z, Gegenava T, Gegenava M, Matoshvili Z, Kasradze S, Kasradze P. Mobile telemonitoring for arrhythmias in outpatients in the Republic of Georgia: a brief report of a pilot study. Telemed J E Health 2012 Sep;18(7):570-571 [FREE Full text] [CrossRef] [Medline]
  31. Karapetyan G, Barseghyan R, Sarukhanyan H, Agaian S. Development and validation of an improved smartphone heart rate acquisition system. Image Process Algorithms Syst XIII 2015;9399 [FREE Full text] [CrossRef]
  32. Jokic S, Krco S, Sakac D, Jokic ID, Delic V. Autonomic telemedical application for Android based mobile devices. 2012 Presented at: Eleventh Symposium on Neural Network Applications in Electrical Engineering; September 20-22, 2012; Belgrade, Serbia. [CrossRef]
  33. Jaworek J, Augustyniak P. A cardiac telerehabilitation application for mobile devices. 2011 Presented at: Computing in Cardiology; September 18-21, 2011; Hangzhou, China.
  34. Issac R, Ajaynath MS. CUEDETA: a real time heart monitoring system using Android smartphone. Cuedeta; 2012 Presented at: India Conference (INDICON); December 7-9, 2012; Kochi, India. [CrossRef]
  35. Işik AH, Güler I. Pulse oximeter based mobile biotelemetry application. Stud Health Technol Inform 2012;181:197-201. [Medline]
  36. de Oliveira IH, Cene VH, Balbinot A. Portable electrocardiograph through Android application. 2015 Presented at: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015; August 25-29, 2015; Milan, Italy p. 6780-6783. [CrossRef]
  37. Hadiyoso S, Usman K, Rizal A. Arrhythmia detection based on ECG signal using Android mobile for athlete and patient. 2015 Presented at: 2015 3rd International Conference on Information and Communication Technology (ICoICT); May 27-29, 2015; Nusa Dua, Bali. [CrossRef]
  38. Gradl S, Kugler P, Lohmuller C, Eskofier B. Real-time ECG monitoring and arrhythmia detection using Android-based mobile devices. Conf Proc IEEE Eng Med Biol Soc 2012;2012:2452-2455. [CrossRef] [Medline]
  39. Filipovic N, Stojanovic R, Lekic N, Caplanova A. Monitoring and analysis of vital physiological parameters using PDA devices. 2014 Presented at: 24th International Conference Radioelektronika (Radioelektronika); April 15-16, 2014; Bratislava, Slovakia.
  40. Filipovic N, Stojanovic R, Debevc M, Devedzic G. On line ECG processing and visualization using Android smartphone. 2013 Presented at: 2nd Mediterranean Conference on Embedded Computing (Meco); June 15-20, 2013; Budva, Serbia. [CrossRef]
  41. Fernandes B, Afonso JA, Simoes R. Vital signs monitoring and management using mobile devices. 2011 Presented at: 6th Iberian Conference on Information Systems and Technologies; June 15-18, 2011; Chaves, Portugal.
  42. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015 Oct;36(7):1452-1457. [CrossRef] [Medline]
  43. Cruz T, Brás S, Soares SC, Fernandes JM. Monitoring physiology and behavior using Android in phobias. Conf Proc IEEE Eng Med Biol Soc 2015 Aug;2015:3739-3742. [CrossRef] [Medline]
  44. Choo KY, Ling HC, Lo YC, Yap ZH, Pua JS, Phan RC, et al. Android based self-diagnostic electrocardiogram system for mobile healthcare. Technol Health Care 2015;23 Suppl 2:S435-S442. [CrossRef] [Medline]
  45. Banos O, Damas M, Glossekotter P, Hermes A, Mende H, Pomares H, et al. Physiodroid: an app for physiological data monitoring. 2013 Presented at: International Work-Conference on Bioinformatics and Biomedical Engineering; March 18-20, 2013; Granada, Spain.
  46. Amiri AM, Abhinav, Mankodiya K. m-QRS: an efficient QRS detection algorithm for mobile health applications. 2015 Presented at: 17th International Conference on E-Health Networking, Application & Services (Healthcom); October 14-17, 2015; Boston, MA, USA. [CrossRef]
  47. Abi Zeid Daou R, Aad E, Nakhle F, Hayek A, Borcsok J. Patient vital signs monitoring via Android application. 2015 Presented at: 2015 International Conference on Advances in Biomedical Engineering (ICABME); Beirut, Lebanon; September 16-18, 2015. [CrossRef]
  48. No authors listed. ECG? There's an app for that!. Harv Heart Lett 2013 Mar;23(7):8. [Medline]
  49. Winkler S, Schieber M, Lücke S, Heinze P, Schweizer T, Wegertseder D, et al. A new telemonitoring system intended for chronic heart failure patients using mobile telephone technology--feasibility study. Int J Cardiol 2011 Nov 17;153(1):55-58. [CrossRef] [Medline]
  50. Vashist SK, Schneider EM, Luong JH. Commercial smartphone-based devices and smart applications for personalized healthcare monitoring and management. Diagnostics (Basel) 2014 Aug 18;4(3):104-128 [FREE Full text] [CrossRef] [Medline]
  51. Saldarriaga AJ, Perez JJ, Restrepo J, Bustamante J. A mobile application for ambulatory electrocardiographic monitoring in clinical and domestic environments. 2013 Presented at: 2013 Pan American Health Care Exchanges (PAHCE); 29 April-4 May, 2013; Medellin, Colombia. [CrossRef]
  52. Plesnik E, Malgina O, Tasic JF, Zajc M. ECG signal acquisition and analysis for telemonitoring. 2010 Presented at: 15th IEEE Mediterranean Electrotechnical Conference (MELECON 2010); April 26-28, 2010; Valletta, Malta. [CrossRef]
  53. Mittal S. Smartphone-based electrocardiographic and cardiac implantable electronic device monitoring. Cardiol Rev 2017;25(1):12-16. [CrossRef] [Medline]
  54. Mattila J, Ding H, Mattila E, Särelä A. Mobile tools for home-based cardiac rehabilitation based on heart rate and movement activity analysis. Conf Proc IEEE Eng Med Biol Soc 2009;2009:6448-6452. [CrossRef] [Medline]
  55. Mateev H, Simova I, Katova T, Dimitrov N. Clinical evaluation of a mobile heart rhythm telemonitoring system. ISRN Cardiol 2012;2012:192670 [FREE Full text] [CrossRef] [Medline]
  56. Madias JE. A proposal for monitoring patients with heart failure via “smart phone technology”-based electrocardiograms. J Electrocardiol 2016;49(5):699-706. [CrossRef] [Medline]
  57. Kumpusch H, Hayn D, Kreiner K, Falgenhauer M, Mor J, Schreier G. A mobile phone based telemonitoring concept for the simultaneous acquisition of biosignals physiological parameters. Stud Health Technol Inform 2010;160(Pt 2):1344-1348. [Medline]
  58. Kumar M, Veeraraghavan A, Sabharwal A. DistancePPG: Robust non-contact vital signs monitoring using a camera. Biomed Opt Express 2015 May 01;6(5):1565-1588 [FREE Full text] [CrossRef] [Medline]
  59. Guzik P, Malik M. ECG by mobile technologies. J Electrocardiol 2016;49(6):894-901. [CrossRef] [Medline]
  60. Gonzalez-Fernandez R, Mulet-Cartaya M, Lopez-Cardona JD, Lopez-Rodriguez R. A mobile application for cardiac rhythm study. 2015 Presented at: Computing in Cardiology Conference (CinC); September 6-9, 2015; Nice, France. [CrossRef]
  61. Garabelli P, Stavrakis S, Po S. Smartphone-based arrhythmia monitoring. Curr Opin Cardiol 2017 Jan;32(1):53-57. [CrossRef] [Medline]
  62. Freedman B. Screening for atrial fibrillation using a smartphone: is there an app for that? J Am Heart Assoc 2016 Jul 21;5(7) [FREE Full text] [CrossRef] [Medline]
  63. Fang DJ, Hu JC, Wei XF, Shao H, Luo YE. A smart phone healthcare monitoring system for oxygen saturation and heart rate. 2014 Presented at: International Conference on Cyber-Enabled Distributed Computing and Knowledge Discovery; October 13-15, 2014; Shanghai, China. [CrossRef]
  64. de Lucena SE, Sampaio D, Mall B, Meyer M, Burkart MA, Keller FV. ECG monitoring using Android mobile phone and Bluetooth. 2015 Presented at: 2015 IEEE International Instrumentation and Measurement Technology Conference (I2MTC) Proceedings; May 11-14, 2015; Pisa, Italy. [CrossRef]
  65. Bal U. Non-contact estimation of heart rate and oxygen saturation using ambient light. Biomed Opt Express 2015 Jan 01;6(1):86-97 [FREE Full text] [CrossRef] [Medline]
  66. Ahamed MA, Hasan MK, Alam MS. Design and implementation of low cost ECG monitoring system for the patient using smartphone. 2015 Presented at: 2015 International Conference on Electrical & Electronic Engineering (ICEEE); November 4-6, 2015; Rajshahi, Bangladesh p. 261-264. [CrossRef]
  67. Bobra NP, Wang ZB, Zhang WF, Luo A. A high-quality, low-energy, small-size system-on-chip (soc) solution enabling ECG mobile applications. 2013 Presented at: 39th Annual Conference of the IEEE Industrial Electronics Society; November 10-13, 2013; Vienna, Austria p. 8406-8409. [CrossRef]
  68. Bolkhovsky JB, Scully CG, Chon KH. Statistical analysis of heart rate and heart rate variability monitoring through the use of smart phone cameras. Conf Proc IEEE Eng Med Biol Soc 2012;2012:1610-1613. [CrossRef] [Medline]
  69. Cheatham SW, Kolber MJ, Ernst MP. Concurrent validity of resting pulse-rate measurements: a comparison of 2 smartphone applications, the polar H7 belt monitor, and a pulse oximeter with bluetooth. J Sport Rehabil 2015 May;24(2):171-178. [CrossRef] [Medline]
  70. Drijkoningen L, Lenaerts F, Van der Auwera J, Leysen K, Nuyens D, Vandervoort P, et al. Validation of a smartphone based photoplethysmographic beat detection algorithm for normal and ectopic complexes. 2014 Presented at: Computing in Cardiology 2014; September 7-10, 2014; Cambridge, MA, USA.
  71. Flatt AA, Esco MR. Validity of the ithleteTM smart phone application for determining ultra-short-term heart rate variability. J Hum Kinet 2013 Dec 18;39:85-92 [FREE Full text] [CrossRef] [Medline]
  72. Garabelli P, Stavrakis S, Albert M, Koomson E, Parwani P, Chohan J, et al. Comparison of QT interval readings in normal sinus rhythm between a smartphone heart monitor and a 12-lead ECG for healthy volunteers and inpatients receiving sotalol or dofetilide. J Cardiovasc Electrophysiol 2016 Jul;27(7):827-832. [CrossRef] [Medline]
  73. Gregoski MJ, Mueller M, Vertegel A, Shaporev A, Jackson BB, Frenzel RM, et al. Development and validation of a smartphone heart rate acquisition application for health promotion and wellness telehealth applications. Int J Telemed Appl 2012;2012:696324 [FREE Full text] [CrossRef] [Medline]
  74. Haberman ZC, Jahn RT, Bose R, Tun H, Shinbane JS, Doshi RN, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015 May;26(5):520-526. [CrossRef] [Medline]
  75. Ho CL, Fu YC, Lin MC, Chan SC, Hwang B, Jan SL. Smartphone applications (apps) for heart rate measurement in children: comparison with electrocardiography monitor. Pediatr Cardiol 2014 Apr;35(4):726-731. [CrossRef] [Medline]
  76. Huang RY, Dung LR. Measurement of heart rate variability using off-the-shelf smart phones. Biomed Eng Online 2016 Jan 29;15:11 [FREE Full text] [CrossRef] [Medline]
  77. Kanva AK, Sharma CJ, Deb S. Determination of spo(2) and heart-rate using smart-phone camera. 2014 Presented at: Proceedings of The 2014 International Conference on Control, Instrumentation, Energy and Communication (CIEC); January 31-February 2, 2014; Calcutta, India p. 237-241. [CrossRef]
  78. Koenig N, Seeck A, Eckstein J, Mainka A, Huebner T, Voss A, et al. Validation of a new heart rate measurement algorithm for fingertip recording of video signals with smartphones. Telemed J E Health 2016 Aug;22(8):631-636. [CrossRef] [Medline]
  79. Lagido RB, Lobo J, Leite S, Sousa C, Ferreira L, Silva-Cardoso J. Using the smartphone camera to monitor heart rate and rhythm in heart failure patients. 2014 Presented at: IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI); June 1-4, 2014; Valencia, Spain p. 556-559. [CrossRef]
  80. Losa-Iglesias ME, Becerro-de-Bengoa-Vallejo R, Becerro-de-Bengoa-Losa KR. Reliability and concurrent validity of a peripheral pulse oximeter and health-app system for the quantification of heart rate in healthy adults. Health Informatics J 2016;22(2):151-159. [CrossRef] [Medline]
  81. Mateev H, Simova I, Katova T, Dimitrov N. Clinical evaluation of a mobile heart rhythm telemonitoring system. ISRN Cardiol 2012;2012:192670 [FREE Full text] [CrossRef] [Medline]
  82. Matsumura K, Yamakoshi T. iPhysioMeter: a new approach for measuring heart rate and normalized pulse volume using only a smartphone. Behav Res Methods 2013 Dec;45(4):1272-1278. [CrossRef] [Medline]
  83. McManus DD, Chong JW, Soni A, Saczynski JS, Esa N, Napolitano C, et al. Pulse-smart: Pulse-based arrhythmia discrimination using a novel smartphone application. J Cardiovasc Electrophysiol 2016 Jan;27(1):51-57. [CrossRef] [Medline]
  84. McManus DD, Lee J, Maitas O, Esa N, Pidikiti R, Carlucci A, et al. A novel application for the detection of an irregular pulse using an iPhone 4S in patients with atrial fibrillation. Heart Rhythm 2013 Mar;10(3):315-319 [FREE Full text] [CrossRef] [Medline]
  85. Nam Y, Kong Y, Reyes B, Reljin N, Chon KH. Monitoring of heart and breathing rates using dual cameras on a smartphone. PLoS One 2016;11(3):e0151013 [FREE Full text] [CrossRef] [Medline]
  86. Papon MTI, Ahmad I, Saquib N, Rahman A. Non-invasive heart rate measuring smartphone applications using on-board cameras: a short survey. 2015 Presented at: 2015 International Conference on Networking Systems and Security (NSysS); January 5-7, 2015; Dhaka, Bangladesh. [CrossRef]
  87. Pelegris P, Banitsas K, Orbach T, Marias K. A novel method to detect heart beat rate using a mobile phone. Conf Proc IEEE Eng Med Biol Soc 2010;2010:5488-5491. [CrossRef] [Medline]
  88. Po LM, Xu XY, Feng LT, Li YM, Cheung KW, Cheung CH. Frame adaptive ROI for photoplethysmography signal extraction from fingertip video captured by smartphone. 2015 Presented at: 2015 IEEE International Symposium on Circuits and Systems (ISCAS); May 24-27, 2015; Lisbon, Portugal p. 1634-1637. [CrossRef]
  89. Scully CG, Lee J, Meyer J, Gorbach AM, Granquist-Fraser D, Mendelson Y, et al. Physiological parameter monitoring from optical recordings with a mobile phone. IEEE Trans Biomed Eng 2012 Feb;59(2):303-306 [FREE Full text] [CrossRef] [Medline]
  90. Wackel P, Beerman L, West L, Arora G. Tachycardia detection using smartphone applications in pediatric patients. J Pediatr 2014 May;164(5):1133-1135. [CrossRef] [Medline]
  91. Kurylyak Y, Lamonaca F, Grimaldi D. Smartphone-based photoplethysmogram measurement. In: Duro RJ, López-Peña F, editors. Digital Image, Signal and Data Processing for Measurement Systems. Denmark: River Publishers; 2012:135-164.
  92. Terbizan DJ, Dolezal BA, Albano C. Validity of seven commercially available heart rate monitors. Meas Phys Educ Exerc Sci 2002 Dec;6(4):243-247. [CrossRef]
  93. Boulos MN, Wheeler S, Tavares C, Jones R. How smartphones are changing the face of mobile and participatory healthcare: an overview, with example from eCAALYX. Biomed Eng Online 2011;10:24 [FREE Full text] [CrossRef] [Medline]
  94. Parak J, Uuskoski M, Machek J, Korhonen I. Estimating heart rate, energy expenditure, and physical performance with a wrist photoplethysmographic device during running. JMIR Mhealth Uhealth 2017 Jul 25;5(7):e97 [FREE Full text] [CrossRef] [Medline]
  95. Fallow BA, Tarumi T, Tanaka H. Influence of skin type and wavelength on light wave reflectance. J Clin Monit Comput 2013 Jun;27(3):313-317. [CrossRef] [Medline]
  96. van Stralen KJ, Jager KJ, Zoccali C, Dekker FW. Agreement between methods. Kidney Int 2008 Nov;74(9):1116-1120 [FREE Full text] [CrossRef] [Medline]
  97. Zaki R, Bulgiba A, Ismail R, Ismail NA. Statistical methods used to test for agreement of medical instruments measuring continuous variables in method comparison studies: a systematic review. PLoS One 2012;7(5):e37908 [FREE Full text] [CrossRef] [Medline]
  98. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986 Feb 8;1(8476):307-310. [Medline]

CASP: Critical Appraisal Skills Programme
ECG: electrocardiogram
PPG: photoplethysmography

Edited by G Eysenbach; submitted 21.08.17; peer-reviewed by N Bruining, K Chon; comments to author 28.09.17; revised version received 03.12.17; accepted 18.12.17; published 27.02.18


©Benjamin De Ridder, Bart Van Rompaey, Jarl K Kampen, Steven Haine, Tinne Dilles. Originally published in JMIR Cardio (, 27.02.2018.

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