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It was administered in doses ranging between 0.01 and 0.1 g/kg, 3 times daily either orally or intravenously (equivalent to 2.4-24 g/d for an 80 kg patient). Among patients with schizophrenia and catatonia, approximately 30 participants, the study showed a reduction of catatonic symptoms ranging from 60% to 70%. Specifically, there were improvements in anxiety, agitation, and restlessness.
JMIR Res Protoc 2025;14:e68356
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Example screenshots of the Study Management and Retention Tool (SMa RT) web application, including the different Combine intervention content sections: (A) log in screen, (B) study timeline, (C) intervention content home screen, (D), health resources section, (E) frequently asked questions about pre-exposure prophylaxis.
This section includes the major time points of the study (baseline, month 6, month 12, month 18, and month 24). It allows participants to see upcoming and previously completed surveys.
JMIR Res Protoc 2025;14:e69540
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Natural Language Processing for Identification of Hospitalized People Who Use Drugs: Cohort Study
The presence of any of the following criteria (ie, abbreviated with the letters B, D, M, and N) were used to qualify the hospitalizations for inclusion in the PWUD cohort:
B (Biomarkers): In line with a previous study, positive urine toxicology for drugs or medications for SUD (eg, cocaine, amphetamine, methadone, suboxone, fentanyl, opiate, oxycodone), positive HCV antibody with positive or quantifiable HCV viral load [29]
D (Diagnostic codes): Presence of ICD-9 and or ICD-10 code for overdose, substance use
JMIR AI 2025;4:e63147
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