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Harm Reduction Contingency Management for Stimulant Use Reduction and Antiretroviral Therapy Adherence in HIV Primary Care: Protocol for an Implementation Effectiveness Study

Harm Reduction Contingency Management for Stimulant Use Reduction and Antiretroviral Therapy Adherence in HIV Primary Care: Protocol for an Implementation Effectiveness Study

We will also report the average frequency of use as captured by weekly timeline follow-back and compare average use at baseline versus study visit 12 (ie, the final visit) using a paired 2-tailed t test. We will use the Mc Nemar test to compare the proportion of participants with HIV viral loads less than 200 copies/m L before and after CM participation.

Gabriela Steiner, Stefan Baral, Elise D Riley, Steven Shoptaw, Gabriel Chamie, Kate Roberts, Lauren Suchman, Kelly Knight, Monica Gandhi, Phillip Coffin, Ayesha Appa

JMIR Res Protoc 2025;14:e67292

Outcomes of an App-Based Intervention to Target Naming Among Individuals With Poststroke Aphasia: Virtual Randomized Controlled Trial

Outcomes of an App-Based Intervention to Target Naming Among Individuals With Poststroke Aphasia: Virtual Randomized Controlled Trial

Group sample sizes of 72 are needed to achieve 80% power to detect a difference in proportions of 0.25 between the null hypothesis and the alternative hypothesis using a 1-tailed t test with a probable α error of 0.05. Accounting for a dropout rate of approximately 10% (based on the dropout rate of Varley et al [41]) from baseline to follow-up, we estimated we would need 79 participants (rounded up to 80).

Esther S Kim, Laura Laird, Carlee Wilson, Steven Stewart, Philip Mildner, Sebastian Möller, Raimund Schatz, Robert P Spang, Jan-Niklas Voigt-Antons, Elizabeth Rochon

JMIR Mhealth Uhealth 2025;13:e67711

Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study

Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study

The primary outcome was quantification of IL-17 secretion from T cell receptor–activated CD4+ T cells isolated from samples collected on day 1 and day 4. The delta (change) in IL-17 secretion was compared using a 2-tailed paired t test. IL-17 secretion in response to TRE was compared between the 2 cohorts using a 2-tailed, 2-sample t test in each study group. The collected samples will also allow hypothesis generation to understand the molecular mechanisms underlying changes in IL-17 secretion.

Sinibaldo Romero Arocha, Kim Han, Rebecca D Huffstutler, Geethika P Thota, Natalie A Macheret, Amber B Courville, Robert J Brychta, Kong Y Chen, Stephanie T Chung, Laura C Coates, Alexander J Clarke, Michael N Sack

JMIR Res Protoc 2025;14:e74999

Optimizing and Testing an Individualized and Adaptive Physical Activity Digital Health Intervention: Protocol for a Control Optimization Trial Embedded Within a Randomized Controlled Trial

Optimizing and Testing an Individualized and Adaptive Physical Activity Digital Health Intervention: Protocol for a Control Optimization Trial Embedded Within a Randomized Controlled Trial

For the comparison of a 12-month change in minutes per week of MVPA from baseline between the intervention and control groups, a 2-sided, 2-sample 2-tailed t test with a significance level of .05 (or a nonparametric approach such as the Wilcoxon rank sum test if parametric assumptions fail) will be conducted. In general, analyses will incorporate the intention-to-treat principle, which includes all participants who are randomized in the analysis.

Meelim Kim, Shadia Mansour-Assi, Mohamed El Mistiri, Junghwan Park, Sarasij Banerjee, Owais Khan, Steven De La Torre, Michael Higgins, Job Godino, Kevin Patrick, Camille Nebeker, Sonia Jain, Predrag Klasnja, Daniel E Rivera, Eric Hekler

JMIR Res Protoc 2025;14:e70599

Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study

Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study

We produced descriptive statistics according to the diagnostic groups (CU and CI) and web-based or in-clinic study setting (BHR and ADNI) and compared demographic and clinical information and ECog scores between groups using independent t test (2-tailed) and chi-square test. To test the first hypothesis that the web-based ECog can distinguish diagnostic groups, we performed binomial logistic regression analyses with the diagnostic group (CU or CI) as the dependent variable.

Jae Myeong Kang, Manchumad Manjavong, Adam Diaz, Miriam T Ashford, Anna Aaronson, Joseph Eichenbaum, Scott Mackin, Rachana Tank, Melanie J Miller, Bernard Landavazo, Erika Cavallone, Diana Truran, Monica R Camacho, Juliet Fockler, Derek Flenniken, Sarah Tomaszewski Farias, Michael W Weiner, Rachel Nosheny

J Med Internet Res 2025;27:e69689

Optimizing Cardiovascular Risk Management in Primary Care Using a Personalized eCoach Solution Enhanced by an Artificial Intelligence–Driven Clinical Prediction Model: Protocol from the Coronary Artery Disease Risk Estimation and Early Detection Consortium

Optimizing Cardiovascular Risk Management in Primary Care Using a Personalized eCoach Solution Enhanced by an Artificial Intelligence–Driven Clinical Prediction Model: Protocol from the Coronary Artery Disease Risk Estimation and Early Detection Consortium

A paired sample t test will be performed for at least the 10-year ASCVD risk, assuming normality. Individual components, including systolic blood pressure, use of blood pressure medication, total cholesterol, HDL, use of lipid-modifying agents, smoking status, and moderate to vigorous physical activity, will be evaluated using the Mc Nemar test for dichotomous outcomes and the paired sample t test for continuous variables.

Rutger van Mierlo, Bart Scheenstra, Joost Verbeek, Anke Bruninx, Petros Kalendralis, Inigo Bermejo, Andre Dekker, Arnoud van 't Hof, Marieke Spreeuwenberg, Laura Hochstenbach

JMIR Res Protoc 2025;14:e66068