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We will also report the average frequency of use as captured by weekly timeline follow-back and compare average use at baseline versus study visit 12 (ie, the final visit) using a paired 2-tailed t test. We will use the Mc Nemar test to compare the proportion of participants with HIV viral loads less than 200 copies/m L before and after CM participation.
JMIR Res Protoc 2025;14:e67292
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Group sample sizes of 72 are needed to achieve 80% power to detect a difference in proportions of 0.25 between the null hypothesis and the alternative hypothesis using a 1-tailed t test with a probable α error of 0.05. Accounting for a dropout rate of approximately 10% (based on the dropout rate of Varley et al [41]) from baseline to follow-up, we estimated we would need 79 participants (rounded up to 80).
JMIR Mhealth Uhealth 2025;13:e67711
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The primary outcome was quantification of IL-17 secretion from T cell receptor–activated CD4+ T cells isolated from samples collected on day 1 and day 4. The delta (change) in IL-17 secretion was compared using a 2-tailed paired t test. IL-17 secretion in response to TRE was compared between the 2 cohorts using a 2-tailed, 2-sample t test in each study group.
The collected samples will also allow hypothesis generation to understand the molecular mechanisms underlying changes in IL-17 secretion.
JMIR Res Protoc 2025;14:e74999
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Implementation of Clinical Practice Guidelines to Prevent Cervical Cancer: Mixed Methods Study
JMIR Cancer 2025;11:e68572
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For the comparison of a 12-month change in minutes per week of MVPA from baseline between the intervention and control groups, a 2-sided, 2-sample 2-tailed t test with a significance level of .05 (or a nonparametric approach such as the Wilcoxon rank sum test if parametric assumptions fail) will be conducted. In general, analyses will incorporate the intention-to-treat principle, which includes all participants who are randomized in the analysis.
JMIR Res Protoc 2025;14:e70599
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We produced descriptive statistics according to the diagnostic groups (CU and CI) and web-based or in-clinic study setting (BHR and ADNI) and compared demographic and clinical information and ECog scores between groups using independent t test (2-tailed) and chi-square test.
To test the first hypothesis that the web-based ECog can distinguish diagnostic groups, we performed binomial logistic regression analyses with the diagnostic group (CU or CI) as the dependent variable.
J Med Internet Res 2025;27:e69689
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A paired sample t test will be performed for at least the 10-year ASCVD risk, assuming normality. Individual components, including systolic blood pressure, use of blood pressure medication, total cholesterol, HDL, use of lipid-modifying agents, smoking status, and moderate to vigorous physical activity, will be evaluated using the Mc Nemar test for dichotomous outcomes and the paired sample t test for continuous variables.
JMIR Res Protoc 2025;14:e66068
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