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Given the multiple correlated biomarker outcomes, we will create a composite outcome derived as a sum of z-scores of the (possibly transformed) markers. A few previous interventions aimed at decreasing sedentary time in adults or increasing standing observed effect sizes between 0.39 and 0.49 on fasting insulin. Thus, we based sample size estimates on an assumed effect size of 0.4 at 3 months.
JMIR Res Protoc 2021;10(5):e28684
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