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This is a multicenter, parallel group RCT of two different algorithms for optimizing tissue oxygenation in adult cardiac surgical patients undergoing nonemergency valve surgery, with or without coronary artery bypass graft (CABG), and using CPB at mild hypothermia (32-35°C). The trial is restricted to these patient groups because they have a higher chance of needing transfusion and needing more RBC units transfused than patients undergoing isolated CABG (Trial Registration Number [ISRCTN]: 23557269).
JMIR Res Protoc 2015;4(4):e137
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Cold cardioplegia is given at a temperature of approximately 4°C and by either antegrade or retrograde delivery (or a mixture of both) according to local protocol.
Anesthetic management adheres strictly to a locally agreed protocol (see Multimedia Appendix 1) and all other aspects of the patient’s preoperative and postoperative management are in accordance with existing protocols in use in the BHI.
JMIR Res Protoc 2014;3(3):e35
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