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Strategies to Improve Health Care Provider Prescription of and Patient Adherence to Guideline-Recommended Cardiovascular Medications for Atherosclerotic Occlusive Disease: Protocol for Two Systematic Reviews and Meta-Analyses of Randomized Controlled Trials

Strategies to Improve Health Care Provider Prescription of and Patient Adherence to Guideline-Recommended Cardiovascular Medications for Atherosclerotic Occlusive Disease: Protocol for Two Systematic Reviews and Meta-Analyses of Randomized Controlled Trials

Interstudy heterogeneity will be assessed by inspecting forest plots and calculating I² statistics [86]. We will consider I² statistics >25%, >50%, and >75% to represent low, moderate, and high degrees of heterogeneity, respectively [86]. We will also conduct stratified meta-analyses and meta-regressions using several prespecified risk factors for underprescription and nonadherence selected based on the findings of related systematic reviews [87-92] and methodological considerations [15,16,93-103].

Aidan M Kirkham, Dean A Fergusson, Justin Presseau, Daniel I McIsaac, Risa Shorr, Derek J Roberts

JMIR Res Protoc 2025;14:e60326

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Outcomes After Receipt of Neuraxial or Regional Anesthesia Instead of General Anesthesia for Lower Limb Revascularization Surgery: Protocol for a Systematic Review and Meta-analysis

Outcomes After Receipt of Neuraxial or Regional Anesthesia Instead of General Anesthesia for Lower Limb Revascularization Surgery: Protocol for a Systematic Review and Meta-analysis

Our focused clinical question was: P: for adults (≥18 years of age) undergoing lower limb revascularization surgery for PAD I(E): does receipt of neuraxial (spinal or epidural) or regional (peripheral nerve block) anesthesia (as the primary anesthetic technique) C: compared with general anesthesia (as the primary anesthetic technique), including general anesthesia combined with other anesthesia techniques O: Result in improved outcomes, including (1) primary outcome (short-term [in-hospital or 30-day] mortality

Derek J Roberts, Hannah Dreksler, Sudhir K Nagpal, Allen Li, Jeanna Parsons Leigh, Timothy Brandys, Prasad Jetty, Luc Dubois, Henry T Stelfox, Daniel I McIsaac

JMIR Res Protoc 2021;10(11):e32170

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Risk Factors for Surgical Site Infection After Lower Limb Revascularization Surgery in Adults With Peripheral Artery Disease: Protocol for a Systematic Review and Meta-analysis

Risk Factors for Surgical Site Infection After Lower Limb Revascularization Surgery in Adults With Peripheral Artery Disease: Protocol for a Systematic Review and Meta-analysis

After vascular surgery, postoperative complications are commonly classified using the Szilagyi grading system, which includes Szilagyi grade I (cellulitis involving the wound), grade II (infection involving subcutaneous tissue), and grade III (infection involving the vascular graft) SSIs [17-19].

Derek J Roberts, Sudhir K Nagpal, Henry T Stelfox, Tim Brandys, Vicente Corrales-Medina, Luc Dubois, Daniel I McIsaac

JMIR Res Protoc 2021;10(9):e28759

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