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Association Between Fatty Liver Index and Incidence of Cataract Surgery in Individuals Aged 50 Years and Older Based on the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) Data: Longitudinal Retrospective Cohort Study

Association Between Fatty Liver Index and Incidence of Cataract Surgery in Individuals Aged 50 Years and Older Based on the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) Data: Longitudinal Retrospective Cohort Study

The FLI is a biomarker for noninvasive fat layer prediction of nonalcoholic fatty liver disease (NAFLD). It has been validated against imaging methods for fatty liver diagnosis in the United States, with an accuracy of 0.84 (95% CI 0.81-0.87) [14]. Also, the FLI was validated with an area under the curve value of 0.87 or 0.785 in the Korean population [20,21].

Yonghwan Kim, Jeongsook Kim, Eoi Jong Seo, Kyung Tae Kim, Jae-woo Lee, Joungyoun Kim, Hee-Taik Kang

JMIR Public Health Surveill 2024;10:e57168

How to Enhance Adherence in Patients with Nonalcoholic Fatty Liver Disease: A Thought-Provoking Issue

How to Enhance Adherence in Patients with Nonalcoholic Fatty Liver Disease: A Thought-Provoking Issue

We read with great interest the article by Kwon et al [1] in the Journal of Medical Internet Research that described an app for lifestyle coaching intervention for patients with nonalcoholic fatty liver disease (NAFLD). With the paradigm shift in medicine, we are delighted to find that the study took into account the importance of psychological and social factors for patients. Digital therapeutics have shown remarkable contributions in various fields [2].

Chunlan Liu, Run Zhou, Junping Shi

J Med Internet Res 2024;26:e59208

Development of Cost-Effective Fatty Liver Disease Prediction Models in a Chinese Population: Statistical and Machine Learning Approaches

Development of Cost-Effective Fatty Liver Disease Prediction Models in a Chinese Population: Statistical and Machine Learning Approaches

Nonalcoholic fatty liver disease (NAFLD) stands as the foremost chronic liver condition, impacting approximately 1.7 billion individuals worldwide. NAFLD manifests as a multifaceted chronic liver disorder marked by an excessive buildup of fat within liver tissue. As hepatic steatosis advances, it exacerbates the onset and progression of hepatitis and fibrosis, while heightening the likelihood of liver cancer.

Liang Zhang, Yueqing Huang, Min Huang, Chun-Hua Zhao, Yan-Jun Zhang, Yi Wang

JMIR Form Res 2024;8:e53654

User Engagement, Acceptability, and Clinical Markers in a Digital Health Program for Nonalcoholic Fatty Liver Disease: Prospective, Single-Arm Feasibility Study

User Engagement, Acceptability, and Clinical Markers in a Digital Health Program for Nonalcoholic Fatty Liver Disease: Prospective, Single-Arm Feasibility Study

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world [1]. NAFLD is defined as >5% fat in the liver (steatosis) among people who drink moderate amounts or no alcohol and have no other chronic liver diseases [2]. NAFLD reflects a spectrum of liver pathologies, ranging from simple steatosis to a more severe condition called nonalcoholic steatohepatitis (NASH), which includes inflammation and potential scarring of the liver [3].

Sigridur Björnsdottir, Hildigunnur Ulfsdottir, Elias Freyr Gudmundsson, Kolbrun Sveinsdottir, Ari Pall Isberg, Bartosz Dobies, Gudlaug Erla Akerlie Magnusdottir, Thrudur Gunnarsdottir, Tekla Karlsdottir, Gudlaug Bjornsdottir, Sigurdur Sigurdsson, Saemundur Oddsson, Vilmundur Gudnason

JMIR Cardio 2024;8:e52576

The Global Prevalence of Nonalcoholic Fatty Liver Disease and its Association With Cancers: Systematic Review and Meta-Analysis

The Global Prevalence of Nonalcoholic Fatty Liver Disease and its Association With Cancers: Systematic Review and Meta-Analysis

NAFLD encompasses a spectrum of diseases including NAFL, which has a more benign course, and NASH, which can progress to cirrhosis and hepatocellular carcinoma (HCC) [6]. Due to the heterogeneous nature of the disease, the undetermined symptoms, and the high disease burden, there is increasing appreciation that NAFLD may also be becoming an important cause of HCC [7]. The reported global prevalence of NAFLD and HCC varies between 2% and 58.5% [8].

Nor Asiah Muhamad, Nur Hasnah Maamor, Fatin Norhasny Leman, Zuraifah Asrah Mohamad, Sophia Karen Bakon, Mohd Hatta Abdul Mutalip, Izzah Athirah Rosli, Tahir Aris, Nai Ming Lai, Muhammad Radzi Abu Hassan

Interact J Med Res 2023;12:e40653

The Effect of Multi-Parametric Magnetic Resonance Imaging in Standard of Care for Nonalcoholic Fatty Liver Disease: Protocol for a Randomized Control Trial

The Effect of Multi-Parametric Magnetic Resonance Imaging in Standard of Care for Nonalcoholic Fatty Liver Disease: Protocol for a Randomized Control Trial

Thus, to investigate the utility and cost-benefit of adding mp MRI into the care pathway of those with suspected NAFLD in Europe (European Union territories and United Kingdom [UK]), this randomized, multi-center, phase 4 control trial to investigate the use of mp MRI as a standardized diagnostic test for NAFLD/NASH was designed.

Dimitar Tonev, Elizabeth Shumbayawonda, Louise Ann Tetlow, Laura Herdman, Marika French, Soubera Rymell, Helena Thomaides-Brears, Filipe Caseiro-Alves, Miguel Castelo-Branco, Carlos Ferreira, Minneke Coenraad, Hildo Lamb, Meinrad Beer, Matt Kelly, Rajarshi Banerjee, Matthias Dollinger, RADIcAL1

JMIR Res Protoc 2020;9(10):e19189

Lifestyle Intervention Enabled by Mobile Technology on Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial

Lifestyle Intervention Enabled by Mobile Technology on Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial

This was part of the routine clinical service offered to overweight or obese NAFLD patients seen at the NAFLD clinic. All outcomes were part of routine measurements taken by trained nurses and blood tests conducted at the outpatient NAFLD clinic. Assessors were not blinded to the groups allocated to the study participants. Body weight was measured using a calibrated digital weighing machine (Seca 767, Germany) to the nearest 0.1 kg.

Su Lin Lim, Jolyn Johal, Kai Wen Ong, Chad Yixian Han, Yiong Huak Chan, Yin Mei Lee, Wai Mun Loo

JMIR Mhealth Uhealth 2020;8(4):e14802

Diet-Induced Alteration of Microbiota and Development of Obesity, Nonalcoholic Fatty Liver Disease, and Diabetes: Study Protocol of a Prospective Study

Diet-Induced Alteration of Microbiota and Development of Obesity, Nonalcoholic Fatty Liver Disease, and Diabetes: Study Protocol of a Prospective Study

Obesity-associated diseases, such as type 2 diabetes mellitus (T2 DM) and nonalcoholic fatty liver disease (NAFLD), are major public health issues worldwide, affecting more than 6% and 25% of the world population, respectively [1,2]. The influence of gut bacteria on the development of obesity and metabolic syndrome is not entirely understood. Numerous experimental studies show that gut bacteria are influential in the development of obesity.

Martine Uittenbogaart, Wouter KG Leclercq, Danielle Bonouvrie, Marleen M Romeijn, Arijan APM Luijten, Steven WM Olde Damink, Francois MH van Dielen, Sander S Rensen

JMIR Res Protoc 2019;8(6):e11553

Web-Based Exercise as an Effective Complementary Treatment for Patients With Nonalcoholic Fatty Liver Disease: Intervention Study

Web-Based Exercise as an Effective Complementary Treatment for Patients With Nonalcoholic Fatty Liver Disease: Intervention Study

In the last few years, nonalcoholic fatty liver disease (NAFLD) has gained attention, owing to its highest increase in the incidence among chronic liver diseases worldwide [3,4,7-9]. Some researchers consider NAFLD as a hepatic manifestation of metabolic syndrome, whereas others consider it a consequence of metabolic syndrome [3,10-13].

Daniel Pfirrmann, Yvonne Huber, Jörn Markus Schattenberg, Perikles Simon

J Med Internet Res 2019;21(1):e11250