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Informatics Interventions for Maternal Morbidity: Scoping Review

Informatics Interventions for Maternal Morbidity: Scoping Review

Maternal morbidities such as preeclampsia and gestational diabetes, and severe maternal morbidities such as postpartum hemorrhage all have implications for the long-term health of mothers well beyond the postpartum period. Preeclampsia is associated with cardiovascular disease for decades following pregnancy, including chronic hypertension, stroke, and age-adjusted overall mortality [2].

Jill Inderstrodt, Julia C Stumpff, Rebecca C Smollen, Shreya Sridhar, Sarah A El-Azab, Opeyemi Ojo, Brendan Bowns, David A Haggstrom

Interact J Med Res 2025;14:e64826

Predictive Modeling of Hypertension-Related Postpartum Readmission: Retrospective Cohort Analysis

Predictive Modeling of Hypertension-Related Postpartum Readmission: Retrospective Cohort Analysis

Similarly, we hypothesized that antihypertensive medication administration and high preeclampsia laboratory values during initial readmission would increase the readmission rate. We obtained institutional review board approval (#2016-006). Individual patient consent was not required due to the retrospective study design. The data set was deidentified before study analysis.

Jinxin Tao, Ramsey G Larson, Yonatan Mintz, Oguzhan Alagoz, Kara K Hoppe

JMIR AI 2024;3:e48588

Five-Feature Models to Predict Preeclampsia Onset Time From Electronic Health Record Data: Development and Validation Study

Five-Feature Models to Predict Preeclampsia Onset Time From Electronic Health Record Data: Development and Validation Study

Preeclampsia diagnosed before 34 weeks of gestation is called early-onset preeclampsia, and late-onset preeclampsia is diagnosed after 34 weeks [4]. To allow for maximal efficiency of prevention therapy, tools that accurately predict the onset time of preeclampsia and the patient risk will be extremely beneficial.

Hailey K Ballard, Xiaotong Yang, Aditya D Mahadevan, Dominick J Lemas, Lana X Garmire

J Med Internet Res 2024;26:e48997

Detection of Urinary Misfolded Proteins for Imminent Prediction of Preeclampsia in Pregnant Women With Suspected Cases: Protocol for a Prospective Noninterventional Study

Detection of Urinary Misfolded Proteins for Imminent Prediction of Preeclampsia in Pregnant Women With Suspected Cases: Protocol for a Prospective Noninterventional Study

Preeclampsia (PE) is one of the most common hypertensive diseases in pregnancy, characterized by elevated blood pressure accompanied by proteinuria or organ damage after 20 weeks of gestation [1]. The incidence of PE is approximately 2%-8% worldwide [2,3], and each year, an estimated 76,000 women and 500,000 fetuses die from PE and related complications [4]. Symptoms of PE are not specific, including headache, visual impairment, upper abdominal pain, and shortness of breath, among others.

Haiyang Tang, Yijia Tian, Jing Fang, Xiaoying Yuan, Minli Yao, Yujia Wang, Yan Feng, Jia Shu, Yan Ni, Ying Yu, Yuanhe Wang, Ping Liang, Xingmin Li, Xiaoxia Bai

JMIR Res Protoc 2024;13:e54026

Use of Machine Learning for Early Detection of Maternal Cardiovascular Conditions: Retrospective Study Using Electronic Health Record Data

Use of Machine Learning for Early Detection of Maternal Cardiovascular Conditions: Retrospective Study Using Electronic Health Record Data

Variables, however, were similarly defined across patients (eg, race, ethnicity, and preeclampsia). The EHR data were deidentified before analyses, enabling HOPE-CAT to truly analyze the data without consideration of race, ethnicity, or other variables that may lead to bias. Race, ethnicity, medical history, and family history were self-reported by patients and defined as recorded in the EHR.

Nawar Shara, Roxanne Mirabal-Beltran, Bethany Talmadge, Noor Falah, Maryam Ahmad, Ramon Dempers, Samantha Crovatt, Steven Eisenberg, Kelley Anderson

JMIR Cardio 2024;8:e53091

Preeclampsia Onset, Days to Delivery, and Autism Spectrum Disorders in Offspring: Clinical Birth Cohort Study

Preeclampsia Onset, Days to Delivery, and Autism Spectrum Disorders in Offspring: Clinical Birth Cohort Study

However, it is unknown whether the increased ASD risk associated with preeclampsia is due to preeclampsia onset or clinical management of preeclampsia after the onset. Identifying the risk associated with preeclampsia onset and exposure is important to provide evidence supporting the care of high-risk pregnancies and to reduce adverse effects on offspring.

Sarah Carter, Jane C Lin, Ting Chow, Mayra P Martinez, Chunyuan Qiu, R Klara Feldman, Rob McConnell, Anny H Xiang

JMIR Public Health Surveill 2024;10:e47396

Vitamin D Deficiency and Its Association With Vitamin D Receptor Gene Variants Among Malaysian Women With Hypertensive Disorders in Pregnancy: Protocol for a Nutrigenomics Study

Vitamin D Deficiency and Its Association With Vitamin D Receptor Gene Variants Among Malaysian Women With Hypertensive Disorders in Pregnancy: Protocol for a Nutrigenomics Study

The spectrum of HDP includes gestational hypertension (GH); preeclampsia; eclampsia; and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. Preeclampsia is a complication of 2%-8% of all pregnancies worldwide, contributing to 16%, 9%, and 1.6%-2.5% maternal deaths globally, in Asia and Africa, and in Malaysia, respectively [4,5]. HDP is one of several disorders associated with vitamin D deficiency [6].

Yakubu Ibrahim, Nurul Iftida, Norshariza Nordin, Amilia Afzan Mohd Jamil

JMIR Res Protoc 2024;13:e53722

Efficacy of mHealth Interventions for Improving Maternal and Neonatal Outcomes Among Pregnant Women With Hypertensive Disorders: Protocol for a Systematic Review

Efficacy of mHealth Interventions for Improving Maternal and Neonatal Outcomes Among Pregnant Women With Hypertensive Disorders: Protocol for a Systematic Review

According to American College of Obstetricians and Gynecologists guidelines, hypertension in pregnancy is classified as chronic or preexisting hypertension, gestational hypertension, preeclampsia or eclampsia, chronic or preexisting hypertension with superimposed preeclampsia-eclampsia, mild hypertension, and severe hypertension [2].

Judith Angelitta Noronha, Mitchelle S Lewis, Tenzin Phagdol, Baby S Nayak, Anupama D, Jyothi Shetty, Ravishankar N, Sreekumaran Nair

JMIR Res Protoc 2023;12:e51792

Magnetic Resonance Imaging Angiography of Physiological and Pathological Pregnancy Placentas Ex Vivo: Protocol for a Prospective Pilot Study

Magnetic Resonance Imaging Angiography of Physiological and Pathological Pregnancy Placentas Ex Vivo: Protocol for a Prospective Pilot Study

Placental dysfunction is a major cause of intrauterine growth restriction (IUGR) or preeclampsia (PE) and is responsible for maternofetal mortality and morbidity such as fetal death, preterm delivery, minor cognitive deficits, school problems, and metabolic syndrome in adulthood [1-3]. Normal placental development is an essential prerequisite for efficient placental function followed by fetal growth.

Matthieu Dap, Bailiang Chen, Claire Banasiak, Gabriela Hossu, Olivier Morel, Marine Beaumont, Charline Bertholdt

JMIR Res Protoc 2022;11(8):e35051