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Digital Health Interventions for Depression and Anxiety in Low- and Middle-Income Countries: Rapid Scoping Review

Digital Health Interventions for Depression and Anxiety in Low- and Middle-Income Countries: Rapid Scoping Review

The Global Burden of Disease 2020 study estimated that the COVID-19 pandemic has led to increases of 28% in major depressive disorders and 26% in anxiety disorders [4], 2 of the most common mental disorders [5]. Depression and anxiety disorders are associated with profound disease and socioeconomic burden to individuals and their relatives [6].

Leena W Chau, Raymond W Lam, Harry Minas, Kanna Hayashi, Vu Cong Nguyen, John O'Neil

JMIR Ment Health 2025;12:e68296

ADAPTed Cognitive Behavioral Therapy for Pediatric Functional Abdominal Pain in Community-Based Pediatric Care: Mixed Methods Study

ADAPTed Cognitive Behavioral Therapy for Pediatric Functional Abdominal Pain in Community-Based Pediatric Care: Mixed Methods Study

Anxiety impacts response to CBT for pain in youth [10]. Thus, Aim to Decrease Anxiety and Pain Treatment (ADAPT) was developed to address both pain and anxiety in youth with FAPD [22]. It was initially developed from evidence-based CBT protocols for the management of pediatric pain [23] and childhood anxiety disorders [24].

Emma Ramsay Milford, Sandra Buratti, Natoshia R Cunningham, Åsa Nilses, Ewa-Lena Bratt, Sandra Weineland

JMIR Form Res 2025;9:e67106

Mindful Nonreactivity, Anxiety, Depression, and Perceived Stress as Mediators of the Mindfulness Virtual Community Intervention—Pathways to Enhance Mental Health in University Students: Secondary Evaluation of Two Randomized Controlled Trials With Student Participants

Mindful Nonreactivity, Anxiety, Depression, and Perceived Stress as Mediators of the Mindfulness Virtual Community Intervention—Pathways to Enhance Mental Health in University Students: Secondary Evaluation of Two Randomized Controlled Trials With Student Participants

Anxiety was evaluated by the Beck Anxiety Inventory (BAI) [52], a 21-item 4-point Likert scale (item range: 0‐3, total score: 0‐63), with higher scores indicating higher levels of anxiety symptoms. Perceived stress was evaluated using the Perceived Stress Scale (PSS), a 10-item, 4-point Likert scale (item range: 0‐4, total score: 0‐40) [53]. Quality of life was evaluated by the 16-item, 7-point (item range: 1‐7, total score: 16‐112) Quality of Life Scale (QOLS) [54].

Meysam Pirbaglou, Christo El Morr, Farah Ahmad, Paul Ritvo

JMIR Ment Health 2025;12:e65853

Effect of Immersive Virtual Reality on Chemotherapy-Related Side Effects in Patients Receiving Paclitaxel-Carboplatin With or Without Bevacizumab: 2-Arm Randomized Controlled Trial

Effect of Immersive Virtual Reality on Chemotherapy-Related Side Effects in Patients Receiving Paclitaxel-Carboplatin With or Without Bevacizumab: 2-Arm Randomized Controlled Trial

Patient anxiety was assessed using the Japanese version of the State-Trait Anxiety Inventory (STAI) [6,7], which consisted of 2 questionnaires: STAI Y-1 and Y-2. STAI “Y” means that this is a new, revised version of the original STAI “X.” The STAI Y-1 examines transient situational reactions (state anxiety) to an anxiety-provoking event, “How you are feeling right now,” using a 4-point scale from 1 (not at all true) to 4 (very true).

Kazuyuki Niki, Satoshi Nakagawa, Misaki Arai, Ayaka Morimoto, Yutaka Ueda

J Med Internet Res 2025;27:e65924

Social-Media-Based Mental Health Interventions: Meta-Analysis of Randomized Controlled Trials

Social-Media-Based Mental Health Interventions: Meta-Analysis of Randomized Controlled Trials

More than 1 in 8 adults and adolescents worldwide live with a mental disorder, with anxiety and depression being the most commonly reported mental health symptoms [1]. Yet, a significant lack of access to mental health services has left more than 70% of those with mental disorders untreated [2,3].

Qiyang Zhang, Zixuan Huang, Yuan Sui, Fu-Hung Lin, Hongjie Guan, Li Li, Ke Wang, Amanda Neitzel

J Med Internet Res 2025;27:e67953

Digital Interventions and Mental Health Outcomes in Patients With Cancer: Systematic Review and Meta-Analysis

Digital Interventions and Mental Health Outcomes in Patients With Cancer: Systematic Review and Meta-Analysis

This demonstrates a significant demand for psychological and mental health services among patients with cancer, leading to urgent calls for the development of multisectoral mental health care approaches, especially those targeting anxiety and depression. For cancer survivors, studies examining anxiety and depression found that 40% experienced moderate to high anxiety, and approximately 20% reported moderate to high depression [7].

Zixuan Wu, Feifei Luo, Siyuan Wang, Xinyu Hu, Meifang Chen

JMIR Cancer 2025;11:e64754

Schema-Informed Digital Mental Health Intervention for Maladaptive Cognitive-Emotional Patterns: Randomized Controlled Trial

Schema-Informed Digital Mental Health Intervention for Maladaptive Cognitive-Emotional Patterns: Randomized Controlled Trial

Jumpy (anxiety, linked to the schema domains of impaired autonomy and performance through the dependence schema, and overvigilance and inhibition through the negativity and pessimism schema) focused on anxiety management, reduction of cognitive distortions, and exposure-based coping techniques. To support engagement, the program incorporated interactive digital worksheets, self-assessments, psychoeducational content, mindfulness audio, and visual prompts.

Seohyun Jeong, Hyeonseong Kim, Silvia Kyungjin Lho, Inae Hwang, Seongjun Mun, Soohyun Kim, Hyejin Lim, Hyeonhee Kim, Min-Sup Shin, Woori Moon

J Med Internet Res 2025;27:e65892

Open Source Web Application (HealthTest) for Emotional Health and Wellness Management in University Students: Development and Usability Study

Open Source Web Application (HealthTest) for Emotional Health and Wellness Management in University Students: Development and Usability Study

A 2020 study conducted in Spain revealed that female health care professionals experienced higher levels of anxiety, stress, and depression compared to their male counterparts, with these issues being more prevalent among individuals aged 20 to 37 years [3]. The prevention and treatment of mental health issues are crucial due to their impact on quality of life and daily functioning [4,5].

Lucrecia Llerena, Daisy Nata Castro, Nancy Rodriguez, Donald Silva Sánchez

Online J Public Health Inform 2025;17:e69413

A Nurse-Led Telemonitoring Approach in Diabetes During the COVID-19 Pandemic: Prospective Cohort Study

A Nurse-Led Telemonitoring Approach in Diabetes During the COVID-19 Pandemic: Prospective Cohort Study

Bespoke health and well-being questionnaires, as well as validated psychological screening tools, were administered, including the Euro Qol Visual Analogue Scale (EQ-VAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7) scale, and Problem Areas in Diabetes (PAID-5) scale [19-22].

Stephanie A Noonan, Amanda L Gauld, Maria I Constantino, Margaret J McGill, Timothy L Middleton, Ian D Caterson, Luigi N Fontana, Stephen M Twigg, Ted Wu, Raaj Kishore Biswas, Jencia Wong

JMIR Diabetes 2025;10:e68214

A Virtual Reality–Based Cognitive Defusion Application for Youth Depression and Anxiety: Mixed Methods Experimental Study

A Virtual Reality–Based Cognitive Defusion Application for Youth Depression and Anxiety: Mixed Methods Experimental Study

VR-CBT typically involves exposure to anxiety-inducing stimuli in virtual environments guided by a clinician (eg, Pot-Kolder et al [17]). Randomized controlled trials have provided robust evidence supporting the efficacy of VR-CBT in improving outcomes in anxiety disorders, psychosis, eating disorders, and trauma-related conditions in adults (see Bell et al [2] for a review).

Imogen H Bell, Cassandra Li, Andrew Thompson, Carli Ellinghaus, Shaunagh O’Sullivan, Kate Alexandra Reynolds, Greg Wadley, Yang Liu, Sarah Bendall, John Gleeson, Lucia Valmaggia, Mario Alvarez-Jimenez

JMIR Ment Health 2025;12:e70160