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Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

There, however, is a growing cohort of young patients with idiopathic dilated cardiomyopathy with HFr EF who are often suboptimally medically treated with minimum prospects of receiving heart transplants. In our opinion, such a group of patients would ideally benefit from ARNIs and SGLT2is. Data from key clinical trials have demonstrated the use of ARNIs as de novo therapy in patients presenting with heart failure [3,10,11].

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025;14:e44027

Disease Progression of Hypertrophic Cardiomyopathy: Modeling Using Machine Learning

Disease Progression of Hypertrophic Cardiomyopathy: Modeling Using Machine Learning

Among them specifically, hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that is a cause of sudden cardiac death (SCD), especially among young adults and athletes [9]. Cardiovascular diseases represent groups of diseases that can greatly benefit from preemptive prediction, prevention, and proactive management; thus, this opens an opportunity for methods of artificial intelligence (AI) [2].

Matej Pičulin, Tim Smole, Bojan Žunkovič, Enja Kokalj, Marko Robnik-Šikonja, Matjaž Kukar, Dimitrios I Fotiadis, Vasileios C Pezoulas, Nikolaos S Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S Maier, Lazar Velicki, Iacopo Olivotto, Guy A MacGowan, Djordje G Jakovljević, Nenad Filipović, Zoran Bosnić

JMIR Med Inform 2022;10(2):e30483

Patient-Reported Outcomes From Patients With Heart Failure Participating in the Future Patient Telerehabilitation Program: Data From the Intervention Arm of a Randomized Controlled Trial

Patient-Reported Outcomes From Patients With Heart Failure Participating in the Future Patient Telerehabilitation Program: Data From the Intervention Arm of a Randomized Controlled Trial

A review from 2016 [14] on the use of PRO instruments in HF management concluded that the Minnesota Living with Heart Failure and Kansas City Cardiomyopathy Questionnaire (KCCQ) were useful PRO instruments in clinical care. However, more studies are needed on the value and interpretability of PRO instruments in clinical settings. The aim of this study is to evaluate the changes in quality of life and well-being among patients with HF, who are participants in the FPT program over the course of 1 year [13].

Cathrine Skov Schacksen, Anne-Kirstine Dyrvig, Nanna Celina Henneberg, Josefine Dam Gade, Helle Spindler, Jens Refsgaard, Malene Hollingdal, Lars Dittman, Kim Dremstrup, Birthe Dinesen

JMIR Cardio 2021;5(2):e26544

Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service

Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service

This results in infantile cardiomyopathy (including stillbirth) and lifelong severe exercise intolerance, lethargy, and fatigue [1]. Low neutrophil numbers (neutropenia), poor feeding, and growth delay are less intuitive but common features [1]. Neutropenia predisposes to serious bacterial infection and is symptomatically treated in two-thirds of UK patients with Barth syndrome via chronic subcutaneous injection therapy with granulocyte-colony stimulating factor—a distressing and expensive medication [2].

Lucy Dabner, Guido E Pieles, Colin G Steward, Julian P Hamilton-Shield, Andrew R Ness, Chris A Rogers, Chiara Bucciarelli-Ducci, Rosemary Greenwood, Lucy Ellis, Karen Sheehan, Barnaby C Reeves

JMIR Res Protoc 2021;10(5):e22533

Risk Factors and Prevalence of Dilated Cardiomyopathy in Sub-Saharan Africa: Protocol for a Systematic Review

Risk Factors and Prevalence of Dilated Cardiomyopathy in Sub-Saharan Africa: Protocol for a Systematic Review

Among the different types of cardiomyopathies, dilated cardiomyopathy (DCM) is by far the most common in sub-Saharan Africa [7-9]. DCM is defined as the presence of left or biventricular dilatation and contractile dysfunction in the absence of abnormal loading conditions (such as hypertension or valve disease) or coronary artery disease that is sufficient to cause global contractile impairment [10].

Lulu Said Fundikira, Pilly Chillo, Linda W van Laake, Reuben Kato Mutagaywa, Amand Floriaan Schmidt, Appolinary Kamuhabwa, Gideon Kwesigabo, Folkert W Asselbergs

JMIR Res Protoc 2021;10(1):e18229