Published on in Vol 1, No 2 (2017): Jul-Dec

A Web-Based Tailored Intervention to Support Illness Management in Patients With an Acute Coronary Syndrome: Pilot Study

A Web-Based Tailored Intervention to Support Illness Management in Patients With an Acute Coronary Syndrome: Pilot Study

A Web-Based Tailored Intervention to Support Illness Management in Patients With an Acute Coronary Syndrome: Pilot Study

Original Paper

1Montreal Heart Institute Research Center, Montréal, QC, Canada

2Faculty of Nursing, Université de Montréal, Montréal, QC, Canada

3Research Center of the Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada

4Research Chair in Innovative Nursing Practices, Montréal, QC, Canada

5Faculty of Nursing, Laval University, Quebec City, QC, Canada

6Montreal Heart Institute, Montreal, QC, Canada

7Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

8Montreal Health Innovations Coordinating Center, Montréal, QC, Canada

Corresponding Author:

Sylvie Cossette, RN, PhD

Montreal Heart Institute Research Center

Room S-2510

5000 Belanger Street

Montréal, QC, H1T 1C8


Phone: 1 514 376 3330 ext 4012

Fax:1 514 593 7441


Background: Illness management after an acute coronary syndrome (ACS) is crucial to prevent cardiac complications, to foster participation in a cardiac rehabilitation (CR) program, and to optimize recovery. Web-based tailored interventions have the potential to provide individualized information and counseling to optimize patient’s illness management after hospital discharge.

Objective: We aimed to assess the feasibility and acceptability of a Web-based tailored intervention (TAVIE@COEUR) designed to improve illness management in patients hospitalized for an ACS. Illness management outcomes were operationalized by self-care, medication adherence, anxiety management, cardiac risk factors reduction, and enrollment in a CR program.

Methods: This posttest pilot study was conducted with one group (N=30) of patients hospitalized for an ACS on the coronary care unit of a tertiary cardiology center. TAVIE@COEUR comprises three Web-based sessions, with a duration ranging from 10 to 45 min and is structured around an algorithm to allow the tailoring of the intervention to different pathways according to patients’ responses to questions. TAVIE@COEUR includes 90 pages, 85 videos, and 47 PDF documents divided across session 1 (S1), session 2 (S2), and session 3 (S3). These sessions concern self-care and self-observation skills related to medication-taking (S1), emotional control and problem-solving skills (S2), and social skills and interacting with health professionals (S3). Throughout the videos, a virtual nurse (providing the intervention virtually) guides the participants in the acquisition of self-care skills. Patients completed S1 of TAVIE@COEUR before hospital discharge and were asked to complete S2 and S3 within 2 weeks after discharge. Feasibility indicators were extracted from the TAVIE@COEUR system. Data regarding acceptability (satisfaction and appreciation of the platform) and preliminary effect (self-care, medication adherence, anxiety management, risk factor reduction, and CR enrollment) were assessed through questionnaires at 1 month following discharge. Preliminary effect was assessed by comparing baseline and 1-month illness management variables.

Results: Of the 30 participants, 20 completed S1, 10 completed S2, and 5 completed S3. Good acceptability scores were observed for ease of navigation (mean=3.58, standard deviation [SD]=0.70; scale=0-4), ease of understanding (mean=3.46, SD=0.63; scale=0-4), and applicability (mean=3.55, SD=0.74; scale=0-4). The lowest acceptability scores were observed for information tailoring (mean=2.93, SD=0.68; scale=0-4) and individual relevance (mean=2.56, SD=0.96; scale=0-4). With regard to preliminary effect, we observed an overall self-care at 1 month following discharge score higher than at baseline (mean at 1 month=54.07, SD=3.99 vs mean at baseline=49.09, SD=6.92; scale-0-60).

Conclusions: Although participants reported general satisfaction and appreciation of TAVIE@COEUR, acceptability and feasibility results show the need for further development of the Web-based intervention to enhance its tailoring before undertaking a full-fledged randomized controlled trial. This may be accomplished by optimizing the adaptability of TAVIE@COEUR to patients’ knowledge, needs, interests, individual capabilities, and emotional and cognitive responses during session completion.

JMIR Cardio 2017;1(2):e4



Health behavior change and illness management play a critical role in the treatment for patients with an acute coronary syndrome (ACS) [1,2]. However, the short hospitalizations following an ACS leave little time for health professionals to provide tailored information and support to patients before discharge [3-6]. This often results in patient’s information needs not being met and, in turn, makes it challenging for them to engage in healthful behaviors and illness management [1,5,7-9]. Illness management is defined as a broad set of strategies and self-care–related behaviors that can be enacted by patients to optimize recovery, reduce their susceptibility to relapses, cope effectively with their symptoms, and manage the impacts of the illness of their quality of life [10]. In the context of cardiovascular diseases, many aspects of illness management such as self-care, medication adherence, anxiety management, cardiac risk factor reduction, and enrollment in a cardiac rehabilitation (CR) program are essential for optimizing recovery and preventing cardiac complications [1,5]. Medication adherence can reduce the risk of all-cause mortality by 35% [7]. Similarly, symptom management and reduction of cardiac risk factors, as promoted in CR programs, are positively linked to cardiac patient outcomes, including increased quality of life and lowered health care services utilization [1,11]. Anxiety management is vital after an ACS, since anxiety may modulate other risk factors such as depression, smoking, sedentary lifestyle, substance abuse, and overweight [12]. Moreover, anxiety is a negative and independent factor influencing adherence to treatment in patients with acute coronary syndrome [13]. Intervention efforts should then focus on engaging ACS patients in practicing self-care, being adherent to their medication, managing their anxiety and cardiac risk factors, and enrolling in a CR program [5,14].

Health professionals in clinical settings play a crucial role in helping patients initiate illness management and health behavior change [1,5]. Clinical practice guidelines clearly state that tailored counseling on the part of health professionals in primary health care settings is a key factor to help patients initiate such behaviors and reduce cardiovascular risk [15-18]. However, it is often reported that nurses and other health professionals neither have the time nor the resources to provide such information and coaching in a timely manner while the patient is hospitalized [19-22]. A recent study on the matter concluded that patient education requires advanced communication skills and pedagogical competences on the part of health professionals. Such skills and competences are needed to provide effective counseling that will result in patients initiating and maintaining illness management–related behaviors [19]. We must then consider that although it is essential to provide tailored counseling to patients following an ACS, only a few health professionals have the necessary knowledge and skills to do so.

Web-based interventions are promising avenues to enhance patient access to information resources post discharge [1,9,23]. Although the number of these technology-driven interventions is growing exponentially in the health care field [24], results on their efficacy remain unclear [1,9,23]. Indeed, some studies have shown that the use of information and communications technologies (ICTs) can positively affect illness management [25,26]. On the other hand, other authors argue that home Internet access, prior Internet experience, and engagement of patients are challenges that must be resolved for Web-based interventions to have a significant effect [27]. A systematic review examining mobile Web-based interventions for self-care related to medication intake showed significant improvement in medication adherence in 18 out of 29 studies [28]. Another systematic review on the same topic by Anglada-Martinez et al [29] showed positive outcomes in 65% of studies, with the authors emphasizing the need for more extensive research. Moreover, to our knowledge, only a few studies have assessed Web-based tailored interventions to improve illness management with ACS patients specifically.

Therefore, the purpose of this pilot study was to develop TAVIE@COEUR, a Web-based tailored intervention including videos showcasing a virtual nurse, and assess its acceptability, feasibility, and preliminary effect for improving illness management in patients hospitalized for an ACS.

Study Design and Setting

The pilot study used a posttest design with one group of ACS patients hospitalized on the Coronary Care Unit (CCU) in a tertiary cardiology center in Canada. The study was approved by the institutional review board of the Montreal Heart Institute Research Center (project number: 11-1320). Our study is reported in accordance with the CONSORT-EHEALTH checklist version 1.6.1. (see Multimedia Appendix 1) [30]. No content or methodological modifications were made after study commencement.


We recruited a convenience sample of patients hospitalized at the CCU. To be included in the study, participants had to be aged >18 years, be hospitalized for an ACS, be discharged to home within 7 days, understand written and spoken French, and have the physical and cognitive abilities to participate. Patients were excluded if they were hospitalized on the CCU for more than 7 days because this would reflect a more difficult ACS recovery, potentially interfering with their physical abilities to participate.


Enrollment and follow-up occurred from June 2014 to August 2015. Participants were recruited during face-to-face encounters with the project nurse at the CCU. After receiving an explanation regarding the study and providing written consent, patients completed a baseline questionnaire. An individual identification number, username, and password were then provided to participants to allow them to log in to the TAVIE@COEUR Web-based platform. The project-dedicated nurse then showed participants how to use TAVIE@COEUR on a tablet computer and invited them to complete the first session (20 min) at the CCU. Participants were then asked to complete the next two sessions of TAVIE@COEUR at home within 2 weeks of discharge.

All patients received usual care during their hospitalization, including a predischarge teaching session by the bedside nurse on resuming activities of daily living, cardiovascular risk factors, and new medications. This included a pamphlet about medication, prevention of complications, local CR program, and postangioplasty care, which is provided to all patients discharged from the CCU following a coronary event.

The TAVIE@COEUR Web-Based Tailored Intervention

TAVIE@COEUR (in French, which translates as YOURLIFE@HEART in English) is a Web-based tailored intervention, including videos in which a virtual nurse interacts with the patient. The ultimate goal of TAVIE@COEUR is to improve patient illness management by providing information and resources tailored to the needs of every patient, while being easily accessible from home. TAVIE@COEUR is completely asynchronous and led by a virtual nurse who guides patients through a learning process regarding the development of illness management skills for self-care and medication adherence (see Figure 1).

Figure 1. TAVIE@COEUR homepage and virtual nurse (in French).
View this figure
Figure 2. Example of specific information provided regarding the medication of each patient (generic and commercial names, indications and tips - in French).
View this figure
Development Process

TAVIE@COEUR is based upon the TAVIE virtual nursing assistance and education Web platform developed by Côté et al [31]. The TAVIE platform was evaluated in different populations such as human immunodeficiency virus (HIV)-positive patients [32].

The TAVIE@COEUR platform was designed with an interdisciplinary team of researchers, nurse practitioners, managers, pharmacists, physicians, and computers scientists. This ensured that everybody involved would agree on the information and content of the platform. All professionals involved in the project team (nurses, pharmacists, and physicians) validated the content, including the information about medication, side effects, therapeutic goals, misuses of medication, and treatment. To ensure feasibility, the managers of the CCU validated the format of the TAVIE@COEUR platform, such as the duration and sequence of sessions. Computer scientists provided feedback on the structure and content of TAVIE@COEUR, as well as measures of acceptability.

To ensure the preservation of data related to TAVIE@COEUR, the website and data regarding its use were hosted on secure computer servers at the research setting.


TAVIE@COEUR could be accessed via a fixed URL. Participants could log in to their account on their home computer or tablet computer using their personal log-in credentials created during their stay at the CCU.


A general overview of the content of the three sessions of TAVIE@COEUR is presented in Table 1. The TAVIE@COEUR intervention is based on a motivational and self-efficacy enhancing framework. More specifically, the interventions of the virtual nurse throughout the 85 videos of TAVIE@COEUR are based on the beliefs and representations of individuals (self-regulation theory by Leventhal; [33]), integrate motivational counseling (works by Miller and Rollnick; [34]), and take into account the stages of change of Prochaska [35].

Table 1. General overview of the content of TAVIE@COEUR.
Sessions and general themeNumber of Web pagesNumber of videosNumber of PDF documents
Home page110
Session 1: Self-care and self-observation skills171435

Session 1 objectives110

Taking your medication330

Identifying or finding out about your medication200

Getting motivated to take your medication113

Associating a positive image to your medication330

Observing your own behavior120

Identifying adverse effects or discomfort112

Managing adverse effects or discomfort2019

Documenting adverse effects or discomfort112

Tips to avoid adverse effects or discomfort110

Integrating strategies for medication-taking119
Session 2: Emotional control and problem-solving skills31287

Session 2 objectives110

Assessing the efficacy of advice100

Managing adverse effects or discomfort420

Associating a positive image to your medication650

Observing your own behavior320

Managing challenges in medication-taking350

Recognizing and changing negative thoughts241

The DECIDEaapproach684

Identifying or finding out about your medication200

Managing adverse effects or discomfort200

Documenting adverse effects or discomfort112
Session 3: Social skills and interacting with health professionals41425

Session 3 objectives220

Associating a positive image to your medication970

Observing your own behavior640

Managing negative feelings670

The DECIDE approach110

Recognizing the importance of support221

Listening and communication skills331

Resources, services, and health professionals3122

Practicing the session strategies211

Managing adverse effects or discomfort420

Identifying or finding out about your medication200

Documenting adverse effects or discomfort110

aDECIDE is an acronym designed for helping patients solve problems. D=Describe the situation in which the oversight occurred to identify your difficulty; E=Express a list of possible strategies to address this challenge; C=Choose the strategy that is most likely to be effective and with which you feel comfortable; I=Imagine yourself using this strategy; D=Decide to take action and face the situation by putting this strategy into practice; E=Evaluate results and resume problem-solving skills when you are not satisfied with the results.

In session 1 (S1), the overarching goal is to develop self-care and self-observation skills. The virtual nurse invites the participant to identify and find out about his medication, while normalizing any possible omission of medication (see Figure 2). She also encourages the participant to continue with successful techniques to optimize medication adherence and recognize signs and symptoms of deterioration or medication side effects. The virtual nurse then suggests possible solutions to any problems in these areas. Session 2 (S2) focuses on emotional control and problem-solving skills. The session addresses possible difficult situations that may lead to nonadherence, for example, travel, restaurants, or activities that can interfere with the daily routine. Negative feelings toward medication, fear of side effects, and confusion about interaction between illicit drugs and prescribed medications are also discussed. Finally, session 3 (S3) focuses on developing patients’ social skills and interactions with family and health care professionals to strengthen their support system and to improve illness management.


TAVIE@COEUR comprises three Web-based sessions, each with a mean duration of 30 min. However, the duration of each session could vary between 10 and 45 min, depending on the needs of each patient and their answers during the navigation. TAVIE@COEUR includes 90 pages, 85 videos, and 47 PDF documents divided across S1, S2, and S3.

TAVIE@COEUR is based on an algorithm allowing a tailored intervention, meaning that throughout the intervention, participants are asked 46 questions (S1: 5 questions, S2: 16 questions, and S3: 25 questions) to tailor the information and resources to their individual needs. For instance, participants are asked to enter their prescription drug information, allowing tailored information to be provided on these specific medications throughout the 3 sessions of the intervention. An example of question asked is: “Do you take ONE of the following medications: Acetylsalicylic Acid, Clopidogrel, Prasugrel, or Ticagrelor?” If the patient answers yes, another question is asked: “During the past week, have you forgotten taking any of your antiplatelet medication?” If the patient answers yes again, a video is presented to provide specific information regarding the benefits of antiplatelet medication and motivational counseling regarding this subject. If the patient answers no to these questions, the intervention proceeds to the next subject. The tailoring of TAVIE@COEUR means that some pages are mandatory for all patients, whereas other pages appear depending on patients’ personal responses. Additionally, PDFs can be accessed to get more detailed information on subjects of interest for the patient.

Use Parameters

Participants completed S1 on tablet computers at the CCU with headphones. We asked participants to complete the two other sessions at home within 2 weeks of discharge.

Level of Human Involvement and Cointerventions

The Web-based tailored intervention was completely asynchronous. The research team was available to provide technical support via mail or telephone. No other intervention was performed during the study.


Sociodemographic and Clinical Data

Baseline sociodemographic and clinical variables were collected for all participants. Some variables were obtained from medical charts such as age, gender, medical diagnosis, and both cardiovascular and noncardiovascular antecedents. Other variables were self-reported, including employment status, education, marital status, and place of residence.

TAVIE@COEUR Feasibility

Feasibility determines “whether the intervention, study design, and procedures can be successfully executed by the researcher and delivered to the participants as planned” [36]. The indicators of feasibility of TAVIE@COEUR were the following: (1) the number of patients who browsed each session, (2) the number of patients who completed each session, and (3) the duration of each session for those who completed it.

TAVIE@COEUR Acceptability

Acceptability determines “the suitability of the intervention and the study procedures from the perspective of the clinical population of interest, the intervention providers, or the health professionals who provide care to the population of interest” [36]. The acceptability of TAVIE@COEUR was measured by the Web-based Nursing Intervention Acceptability Scale developed by Côté et al [32]. The scale includes 21 items assessing satisfaction in 8 dimensions: ease of navigation, ease of understanding, credibility, tailoring of information, individual pertinence, applicability, appreciation of user interface design, and general appreciation. Patients indicated the degree to which they agreed with each statement from not at all (0) to totally (4). The score for each dimension was calculated by summing the scores for the items therein and dividing the result by the number of items in the dimension to standardize the reported means and allow comparison between dimensions. A higher total score for each dimension indicates greater acceptability (possible range: 0-4).

TAVIE@COEUR Preliminary Effect

Preliminary effect measures in illness management (self-care, medication adherence, anxiety management, cardiac risk factors reduction, and CR enrollment) were assessed at baseline and at 1 month after discharge by telephone. Enrollment in a CR program, hospitalizations, and emergency visits were assessed at 1 and 3 months.

Self-care was assessed with the Therapeutic Self-Care Scale (TSCS) that measures actions taken by a patient to promote, maintain, or improve health; prevent sickness; detect and manage symptoms; and regain normal functioning [37]. Patients indicated whether they agreed with each statement from not at all (0) to totally (5), with higher total scores indicating better self-care reported abilities (possible range: 0-60). Cronbach alpha coefficients for the total score were ranged between .88 and .93 [38]. We also used the three subscores proposed by Chaboyer et al [39], who conducted a principal component analysis. The three subscores included perceived capabilities of taking medications (alpha: .80 and .79 for the 3- and 6-months data, respectively, in their study), recognizing and managing symptoms (alpha: .71 and .70 for the 3- and 6-months data, respectively), and managing changes in health conditions (alpha: .48 and .50, for the 3- and 6-months data, respectively) [39].

Medication adherence was assessed with the Morisky Self-Reported Medication-Taking Scale (SRMTS) [40] that assesses reasons for nonadherence. Patients indicated whether (1) or not (0) they forgot, omitted, were careless, or stopped their medication when feeling better at 30 days after discharge (possible range: 0-4). A total score of zero (0) represents no omission of medication, reflecting high adherence; a score of 1 or 2, medium adherence; and a score of 3 or 4, low adherence [40]. Morisky et al [40] reported a Cronbach alpha of .61.

Anxiety was assessed with the State-Trait Anxiety Inventory–State version [41] that includes negatively-worded and positively-worded items. Patients indicated whether they agreed with each statement from “not at all” (1) to “a lot” (4). Higher scores indicate higher anxiety levels (possible range: 20-80). Spielberger et al [41] reported internal consistency coefficients ranging from .86 to .95 and test-retest reliability coefficients ranging from .65 to .75 over 2 months [42].

Cardiac risk factors were assessed using the questionnaire Do you have a healthy heart? [43] that measures the following risk factors: age, gender, menopausal status, heredity, physical exercise, smoking, waist size, weight, diabetes, arterial tension, as well as levels of cholesterol (total, high- and low-density lipoprotein) and of triglycerides. Each item is rated differently. For instance, for physical activity, the following question is asked: “In general, how many days per week are you physically active for at least 30 minutes (walking, dancing, sports, workout, etc; does not have to be a continuous 30 minutes).” Possible answers include less than once a week, 1 to 2 times per week, and 3 to 4 times per week. Scores for each item were added to obtain a total score representing a patient’s level of risk; higher scores representing a higher level of risk (possible range: 0-144). No studies have yet established the validity of the scale, which was created by experts for clinical purposes. However, in a previous study, the Cronbach alpha was .71 [44].

Information on enrollment in a local CR program, hospitalizations, and emergency room visits was collected from the electronic medical charts of the research hospital.

Sample Size

In accordance with pilot study guidelines, we targeted a sample size of 30 participants [45,46]. No power analyses were performed in the context of a pilot study.

Statistical Analysis

Descriptive statistics such as means and standard deviations (SDs) were used for continuous variables, whereas count and percentage were used for dichotomous variables. As this was a pilot study, no inferential analyses were planned; preliminary effect results being provided strictly for illustrating general trends as recommended in pilot study methodology [46].

Characteristics of the Sample

Participants (N=30) were enrolled in the study from May 2014 to June 2015. Most participants were men, with a mean age of 59 years (SD 9). The majority of the participants were born in Canada and living with a partner (see Table 2).

Table 2. Participants’ baseline sociodemographic and clinical data (N=30).
Characteristicn (%)
Sex (male)26 (87)
Place of birth (Canada)24 (80)
Living situation (with a partner)23 (77)
Employment status (employed)16 (53)
Education (high school or higher)15 (50)
Medical antecedents (≥1)20 (67)
Cardiovascular antecedents (≥1)11 (37)
Medical diagnostic

Myocardial infarction (STEMI)18 (60)

Myocardial infarction (NSTEMI)7 (23)

Unstable angina pectoris5 (17)
Cardiovascular risk factors

Alcohol use19 (63)

Hypertension16 (53)

Hypercholesterolemia15 (50)

Physical inactivity15 (50)

Stress15 (50)

Family history of cardiovascular disease14 (47)

Smoking13 (43)

Obesity10 (33)

TAVIE@COEUR Feasibility

As shown in Table 3, S1, S2, and S3 were browsed by 30, 17, and 10 participants, respectively. Of these participants, 20 out of 30 completed the mandatory pages in S1, 10 participants completed the mandatory pages in S2, and 5 participants completed the mandatory pages in S3. For those who completed the mandatory pages, the first session lasted a mean of 25 min, whereas the second and third sessions lasted around 16 min.

TAVIE@COEUR Acceptability

The general level of satisfaction toward TAVIE@COEUR stayed mostly the same following S1 and following either S2, S3, or both (see Table 4). Items that scored the highest on the acceptability scale were related to the ease of navigation throughout TAVIE@COEUR and the ease of understanding the textual and video content of TAVIE@COEUR. Items that scored the lowest were related to the tailoring of the information and the individual relevance of content in TAVIE@COEUR. Patients identified other areas for improvement such as the pacing of the intervention by the virtual nurse, which they felt was not tailored to their needs. Some believed the content to be less suitable for people who already had a good knowledge of disease and drugs, whereas other patients would have preferred more information on how to prevent the recurrence of cardiac events.

Certain aspects of the intervention scored higher after S1 (tailoring of information and individual relevance), whereas other factors pertaining to the interface scored higher after S3 (ease of navigation and user interface design).

Table 3. Feasibility of TAVIE@COEUR (N=30).
Feasibility outcomesMean (SDa) or n (%)
Session 1

Participants who began the session, n (%)30 (100)

Participants who completed the session, n (%)20 (67)

Mean duration of session if completed, in minutes, mean (SD)25 (9)
Session 2

Participants who began the session, n (%)17 (57)

Participants who completed the session, n (%)10 (33)

Mean duration of session if completed, in minutes, mean (SD)16 (7)
Session 3

Participants who began the session, n (%)10 (33)

Participants who completed the session, n (%)5 (17)

Mean duration of session if completed, in minutes, mean (SD)16 (5)

aSD: standard deviation.

Table 4. TAVIE@COEUR acceptability (n=26).
Outcome variableNumber of itemsPossible rangeStandardized mean (SDa) score after session 1Standardized mean (SD) score after sessions 2, session 3 or both
Ease of navigation20-43.35 (0.74)3.58 (0.70)
Ease of understanding20-43.43 (0.78)3.46 (0.63)
Credibility of the information10-42.91 (0.92)3.27 (0.70)
Tailoring of the information40-43.26 (0.57)2.93 (0.68)
Individual relevance40-42.97 (0.73)2.56 (0.96)
Applicability10-43.09 (0.87)3.55 (0.74)
Appreciation of user interface50-42.94 (0.67)3.04 (0.74)
General appreciation20-43.27 (0.72)3.24 (0.87)
General satisfaction score210-43.14 (0.57)3.02 (0.61)

aSD: standard deviation.

TAVIE@COEUR Preliminary Effect

We observed that an overall self-care score 1 month post discharge was higher than the baseline score (see Table 5). Moreover, post-intervention scores for the three dimensions of self-care (medication-taking, recognizing and managing symptoms, and managing changes in the health condition) were all higher than baseline scores.

Responses on the medication adherence scale were skewed toward the score of 0: half of patients reported no omission (score of 0) of medication at 1 month after discharge. Therefore, patients were classified as either reporting no omission (score of 0) versus scores ≥1 omissions. When examining each of the four items of the SRMTS scale, the main reason for nonadherence was forgetting (item 1) to take medication. Seven percent (2 out of 27) of patients scored on either items 2 to 4 on omission, being careless, and stopping medication when feeling better. Patients generally reported a low anxiety level at 1 month post discharge.

Table 5. TAVIE@COEUR preliminary effect.
Outcome variableNumber of itemsPossible rangeMean (SDa) score at baseline (n=30)Mean (SD) score or n (%) at 1 month (n=27)
Overall self-care120-6049.09 (6.92)54.07 (3.99)

Self-care related to medication-taking30-1511.35 (2.41)13.74 (1.32)

Self-care related to recognizing and managing symptoms40-2015.69 (3.49)16.86 (2.36)

Self-care related to managing changes in health condition30-1513.24 (2.29)14.19 (1.47)
Medication adherence (no omission), n (%)NANANA14 (52)
Anxiety2020-80NA33.36 (12.28)
Cardiac risk factors250-144NA83.96 (11.25)
Enrollment in cardiac rehabilitation, n (%)NANANA12 (40)

aSD: standard deviation.

Principal Findings

We developed and pilot-tested TAVIE@COEUR, a Web-based tailored intervention aimed at supporting illness management in patients hospitalized for an ACS. Feasibility and acceptability results suggest some strengths such as the ease of navigation and the content of TAVIE@COEUR but also underline the need for further development of TAVIE@COEUR. Indeed, we believe that further tailoring of TAVIE@COEUR should be done before undertaking a full-fledged randomized controlled trial (RCT). This may be necessary to increase the engagement of participants to complete all sessions, possibly by interchanging some concrete and more abstract content across the sessions. Preliminary effect results are promising, with improved self-care scores 1 month post discharge related to medication-taking, management of symptoms, and management of changes in the health condition.

Although acceptability scores regarding the TAVIE@COEUR Web-based tailored intervention were generally good, the low completion rate of the 3 sessions underline the significant challenges related to optimizing engagement and adherence in Web-based interventions for illness management. Participants appreciated the ease of navigation throughout the Web-based platform, the ease of understanding of the textual and multimedia content, and the applicability of the information in TAVIE@COEUR. However, relatively low scores were observed for other dimensions of the acceptability questionnaire, such as individual relevance and tailoring of the information; some participants felt that TAVIE@COEUR was not tailored enough to their needs. Moreover, feasibility was not optimal since the global participation rate in the Web-based intervention decreased over the three sessions: 20 out of 30 participants completed S1 (at the CCU), 10 completed S2 (at home), and 5 completed S3 (at home). The lower-than-normal participation rate in the second and third sessions of TAVIE@COEUR may be explained by a variety of factors, including lower motivation to continue the intervention up to the end and lack of individual relevance of the intervention content in the third session. Indeed, it is possible that the content of S3, focusing on social skills and interactions with health professionals, was seen less relevant to participants’ needs, especially because they received all crucial information on medication adherence during the first two sessions. However, the mean duration of sessions was consistent throughout the intervention, suggesting that participants who completed S3 were similarly engaged in the intervention.

More and more electronic health (eHealth) apps and Web-based interventions are addressing health behavior change and are being evaluated in patients with various chronic illnesses [47-49]. Patients’ engagement in completing Web-based interventions is often reported in eHealth intervention research as being about 50% of patients recruited [50,51]. This means that dropout rates of around 50% are observed in several Web-based interventions, limiting their effectiveness in initiating and maintaining changes in health behaviors in patients with cardiovascular diseases [47,48,51-54]. This phenomenon is explained at least, in part, by the fact that most existing Web-based interventions, even those that are called individualized, do not take into account the navigation behavior, knowledge, preferences, and individual objectives of the real-time users [51].

We believe the true challenge lies in developing new strategies for engaging participants with various information needs and individual capabilities in Web-based interventions, such as TAVIE@COEUR. In this study, tailoring was ensured by participants following their own paths, choosing to skip or view the videos, and selecting the appropriate resources to match their needs. However, the general theme of the intervention (illness management geared toward medication-taking) was similar for all participants. We observed that, whereas all participants went through the same life-threatening coronary event and associated medical treatment, their information needs varied widely, more than anticipated with the tailoring allowed in TAVIE@COEUR. Some participants felt the content of TAVIE@COEUR provided more than enough information for their needs, whereas other patients would have liked different resources not related to medication-taking because they were already accustomed to taking medication regularly.

The findings of this study suggest the need for more variety in the options offered to each individual to better match the individual needs of each patient [55,56]. For instance, intelligent tutoring systems (ITS) show great promise to provide tailored resource to patients by adapting the structure and content of the training to learners’ knowledge, preferences, and individual capabilities by using some components of artificial intelligence [57]. ITS are generally conceptualized using four models: (1) the interface model, by which the participant interacts with the ITS; (2) the domain model, which represents the knowledge to learn (clinical and theoretical content); (3) the learner model, which takes into account the knowledge, preferences, and individual capabilities of each participant; and (4) the tutor model representing the pedagogical strategies used throughout the ITS [58]. The combination of these four models, through the use of machine learning and data mining, allow for the tailoring of the instruction to each participant [58]. Whereas ITS with various levels of complexity have been evaluated in academic settings with positive results, very few ITS have been assessed with patients in health care settings [59,60]. We can hypothesize that user-modeling at the beginning of TAVIE@COEUR could allow to better target patients with illness management problems related to medication-taking and redirect those who are okay to other resources related, for example, to nutritional guidelines or ACS pathophysiology. In this sense, we believe a widest range of content should be developed to better represent the interests and needs of patients affected by cardiac diseases.

Future research should also focus on developing new strategies for engaging participants in Web-based interventions, such as interactive feedback based on real-time emotional and cognitive responses, online support groups, serious games, and blended Web-based or in-person interventions. Increasing the accessibility of such interventions is also an important challenge; researchers should make sure that Web-based interventions are adaptive to the devices preferred by each patient (ie, mobile phone, tablet, or computer) [28,29].

Strengths and Limitations of the Study

The strengths of the study include adherence to the pilot study protocol and the development of an innovative and complex Web-based tailored intervention.

The limitations of this study mostly relate to pilot study characteristics; the single-group, pre-post study design did not allow for causal inferences or for having enough statistical power to detect statistically significant differences. However, this is expected in a pilot study [45,46]. High dropout rates were observed, particularly in the second and third session of the intervention, leading us to believe that changes must be made to the TAVIE@COEUR Web-based intervention before undertaking an RCT. Finally, we observed in our results that the Morisky SRMTS was not designed for properly quantifying the percentage of medication adherence [38]. Future studies should consider using a different tool or scale for measuring more precisely adherence, such as the medication possession ratio [6,52].


Web-based tailored interventions such as TAVIE@COEUR show potential to support illness management for patients in all clinical settings. However, significant challenges remain, and future research must be conducted to optimize factors related to the tailoring of such interventions to patients’ knowledge, needs, interests, and individual capabilities. We strongly believe the right combination of these factors could contribute to the way in which care is provided in health care settings for years to come. With continued population acceptance of Internet use, Web-based interventions are expected to grow exponentially in content and in complexity. Health professionals have an important role to play in keeping these interventions focused on patients and their families to optimize clinical outcomes.


The authors would like to thank the patients who generously agreed to participate. They acknowledge the participation of Marguerite Renaud, registered nurse (RN); Marie-Hélène Carbonneau, RN, former Director of Nursing; and Marie-Josée Simard, RN, former chief nurse of the CCU from the Montreal Heart Institute. Additionally, they would like to highlight the collaboration of Martine Lacroix and Nancy Frasure-Smith.

The project was possible with the collaboration of iTech consulting Canada, the Centre d’expertise numérique pour la recherche-Bureau de la recherche, développement et valorisation at the Université de Montréal (Isabelle Lépine and Alina Ivanova); the Canadian pharmacist association; and the Multimedia Production of the Centre Hospitalier de l’Université de Montréal (Mikael Ohana et Philippe Lacroix). The team would also like to acknowledge the support from the Quebec Nursing Intervention Research Network, the Fonds de recherche Québec-Santé, the Faculty of Nursing of l’Université de Montréal, as well as from the Montreal Heart Institute Foundation and Research Center. Finally, they would like to thank Kate Johnson for her careful editing of the manuscript.

Authors' Contributions

All authors contributed to manuscript writing, as well as read and approved the final manuscript. SC and JC contributed to study conception and design, data collection and conception of the analytical plan, manuscript writing, and final approval of the manuscript; GR contributed to study conception and design of the content of the Web-based tailored intervention, and final approval of the manuscript; MR and SH contributed to study conception and design and final approval of the manuscript; TM and GF contributed to study conception and design, patient recruitment and follow-up, statistical analysis, manuscript writing, and final approval of the manuscript; CC contributed to statistical analysis and final approval of the manuscript; and JFT and JD contributed to study conception and design and final approval of the manuscript.

Conflicts of Interest

SC and JC have financial stakes in TAVIE@COEUR, which could be commercialized in a near future, as discussions are ongoing with a third party having expressed interest in the application.

Multimedia Appendix 1


PDF File (Adobe PDF File), 820KB

  1. Burke LE, Ma J, Azar KM, Bennett GG, Peterson ED, Zheng Y, American Heart Association Publications Committee of the Council on Epidemiology and Prevention, Behavior Change Committee of the Council on Cardiometabolic Health, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, Council on Quality of Care and Outcomes Research, and Stroke Council. Current science on consumer use of mobile health for cardiovascular disease prevention: a scientific statement from the American heart association. Circulation 2015 Sep 22;132(12):1157-1213. [CrossRef] [Medline]
  2. Perk J, De BG, Gohlke H, Graham I, Reiner Z, Verschuren M, European Association for Cardiovascular Prevention & Rehabilitation (EACPR), ESC Committee for Practice Guidelines (CPG). European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012 Jul;33(13):1635-1701. [CrossRef] [Medline]
  3. van GE, Philbert D, van BC, van DL, Bos M, Bouvy M. Patients' satisfaction with information and experiences with counseling on cardiovascular medication received at the pharmacy. Patient Educ Couns 2011 Jun;83(3):303-309. [CrossRef] [Medline]
  4. Dragomir A, Côté R, Roy L, Blais L, Lalonde L, Bérard A, et al. Impact of adherence to antihypertensive agents on clinical outcomes and hospitalization costs. Med Care 2010 May;48(5):418-425. [CrossRef] [Medline]
  5. Riegel B, Moser D, Anker S, Appel L, Dunbar S, Grady K, American Heart Association Council on Cardiovascular Nursing, American Heart Association Council on Cardiovascular Nursing, American Heart Association Council on Clinical Cardiology, American Heart Association Council on Nutrition‚ Physical Activity‚Metabolism, American Heart Association Interdisciplinary Council on Quality of CareOutcomes Research. State of the science: promoting self-care in persons with heart failure: a scientific statement from the American Heart Association. Circulation 2009 Sep 22;120(12):1141-1163 [FREE Full text] [CrossRef] [Medline]
  6. Ho P, Bryson C, Rumsfeld J. Medication adherence: its importance in cardiovascular outcomes. Circulation 2009 Jun 16;119(23):3028-3035 [FREE Full text] [CrossRef] [Medline]
  7. Chowdhury R, Khan H, Heydon E, Shroufi A, Fahimi S, Moore C, et al. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur Heart J 2013 Oct;34(38):2940-2948. [CrossRef] [Medline]
  8. Kramer J, Hammill B, Anstrom K, Fetterolf D, Snyder R, Charde J, et al. National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance. Am Heart J 2006 Sep;152(3):454.e1-454.e8. [CrossRef] [Medline]
  9. Vosbergen S, Mulder-Wiggers J, Lacroix J, Kemps H, Kraaijenhagen R, Jaspers M, et al. Using personas to tailor educational messages to the preferences of coronary heart disease patients. J Biomed Inform 2015 Feb;53:100-112 [FREE Full text] [CrossRef] [Medline]
  10. Mueser KT, Corrigan PW, Hilton DW, Tanzman B, Schaub A, Gingerich S, et al. Illness management and recovery: a review of the research. Psychiatr Serv 2002 Oct;53(10):1272-1284. [CrossRef] [Medline]
  11. Dickson V, Nocella J, Yoon H, Hammer M, Melkus G, Chyun D. Cardiovascular disease self-care interventions. Nurs Res Pract 2013;2013:407608 [FREE Full text] [CrossRef] [Medline]
  12. Allgulander C. Anxiety as a risk factor in cardiovascular disease. Curr Opin Psychiatry 2016 Jan;29(1):13-17. [CrossRef] [Medline]
  13. Dempe C, Jünger J, Hoppe S, Katzenberger M, Möltner A, Ladwig K, et al. Association of anxious and depressive symptoms with medication nonadherence in patients with stable coronary artery disease. J Psychosom Res 2013 Feb;74(2):122-127. [CrossRef] [Medline]
  14. Riegel B, Dickson VV. A situation-specific theory of heart failure self-care. J Cardiovasc Nurs 2008;23(3):190-196. [CrossRef] [Medline]
  15. Artinian N, Fletcher G, Mozaffarian D, Kris-Etherton P, Van HL, Lichtenstein A, American Heart Association Prevention Committee of the Council on Cardiovascular Nursing. Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the American Heart Association. Circulation 2010 Jul 27;122(4):406-441 [FREE Full text] [CrossRef] [Medline]
  16. Teoh H, Després JP, Dufour R, Fitchett DH, Goldin L, Goodman SG, et al. A comparison of the assessment and management of cardiometabolic risk in patients with and without type 2 diabetes mellitus in Canadian primary care. Diabetes Obes Metab 2013 Dec;15(12):1093-1100. [CrossRef] [Medline]
  17. Cardiometabolic Risk Working Group: Executive Committee, Leiter L, Fitchett D, Gilbert R, Gupta M, Mancini G, et al. Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary). Can J Cardiol 2011;27(2):124-131. [CrossRef] [Medline]
  18. Teoh H, Després JP, Dufour R, Fitchett DH, Goldin L, Goodman SG, et al. Identification and management of patients at elevated cardiometabolic risk in canadian primary care: how well are we doing? Can J Cardiol 2013 Aug;29(8):960-968. [CrossRef] [Medline]
  19. Svavarsdóttir MH, Sigurðardóttir ÁK, Steinsbekk A. Knowledge and skills needed for patient education for individuals with coronary heart disease: the perspective of health professionals. Eur J Cardiovasc Nurs 2016 Feb;15(1):55-63. [CrossRef] [Medline]
  20. Jansink R, Braspenning J, van DW, Elwyn G, Grol R. Primary care nurses struggle with lifestyle counseling in diabetes care: a qualitative analysis. BMC Fam Pract 2010 May 25;11:41 [FREE Full text] [CrossRef] [Medline]
  21. Wiley E, Irwin J, Morrow D. Health Care Practitioners' perceptions of motivational interviewing training for facilitating behaviour change among patients. J Allied Health 2012;41(3):131-139. [Medline]
  22. Noordman J. Nivel. 2013. Lifestyle counseling by physicians and practice nurses in primary care   URL: [accessed 2017-08-10] [WebCite Cache]
  23. Piette J, List J, Rana G, Townsend W, Striplin D, Heisler M. Mobile health devices as tools for worldwide cardiovascular risk reduction and disease management. Circulation 2015 Nov 24;132(21):2012-2027 [FREE Full text] [CrossRef] [Medline]
  24. Bryant Howren M, Van Liew J, Christensen A. Advances in patient adherence to medical treatment regimens: the emerging role of technology in adherence monitoring and management. Soc Personal Psychol Compass 2013 Jul 08;7(7):427-443. [CrossRef]
  25. Granger B, Bosworth H. Medication adherence: emerging use of technology. Curr Opin Cardiol 2011 Jul;26(4):279-287 [FREE Full text] [CrossRef] [Medline]
  26. Hayakawa M, Uchimura Y, Omae K, Waki K, Fujita H, Ohe K. A smartphone-based medication self-management system with realtime medication monitoring. Appl Clin Inform 2013;4(1):37-52 [FREE Full text] [CrossRef] [Medline]
  27. Kerr C, Murray E, Noble L, Morris R, Bottomley C, Stevenson F, et al. The potential of Web-based interventions for heart disease self-management: a mixed methods investigation. J Med Internet Res 2010 Dec 02;12(4):e56 [FREE Full text] [CrossRef] [Medline]
  28. Park L, Howie-Esquivel J, Chung M, Dracup K. A text messaging intervention to promote medication adherence for patients with coronary heart disease: a randomized controlled trial. Patient Educ Couns 2014 Feb;94(2):261-268. [CrossRef] [Medline]
  29. Anglada-Martinez H, Riu-Viladoms G, Martin-Conde M, Rovira-Illamola M, Sotoca-Momblona J, Codina-Jane C. Does mHealth increase adherence to medication? results of a systematic review. Int J Clin Pract 2015 Jan;69(1):9-32. [CrossRef] [Medline]
  30. Eysenbach G, CONSORT-EHEALTH Group. CONSORT-EHEALTH: improving and standardizing evaluation reports of web-based and mobile health interventions. J Med Internet Res 2011 Dec 31;13(4):e126 [FREE Full text] [CrossRef] [Medline]
  31. Côté J, Ramirez-Garcia P, Rouleau G, Saulnier D, Guéhéneuc YG, Hernandez A, et al. A nursing virtual intervention: real-time support for managing antiretroviral therapy. Comput Inform Nurs 2011;29(1):43-51. [CrossRef] [Medline]
  32. Côté J, Rouleau G, Godin G, Ramirez-Garcìa P, Guéhéneuc YG, Nahas G, et al. Acceptability and feasibility of a virtual intervention to help people living with HIV manage their daily therapies. J Telemed Telecare 2012 Oct;18(7):409-412. [CrossRef] [Medline]
  33. Leventhal H, Safer MA, Panagis DM. The impact of communications on the self-regulation of health beliefs, decisions, and behavior. Health Educ Q 1983;10(1):3-29. [Medline]
  34. Miller W, Moyers T. Eight stages in learning motivational interviewing. J Teaching Addict 2006 Jan;5(1):3-17. [CrossRef]
  35. Prochaska JO, DiClemente CC. Self change processes, self efficacy and decisional balance across five stages of smoking cessation. Prog Clin Biol Res 1984;156:131-140. [Medline]
  36. Feeley N, Cossette S, Côté J, Héon M, Stremler R, Martorella G, et al. The importance of piloting an RCT intervention. Can J Nurs Res 2009 Jun;41(2):85-99. [Medline]
  37. Sidani S, Doran D. Flintbox. 2005. Therapeutic self-care measure   URL: [accessed 2017-08-10] [WebCite Cache]
  38. Doran D, Harrison M, Laschinger H, Hirdes J, Rukholm E, Sidani S, et al. Relationship between nursing interventions and outcome achievement in acute care settings. Res Nurs Health 2006 Feb;29(1):61-70. [CrossRef] [Medline]
  39. Chaboyer W, Ringdal M, Aitken L, Kendall E. Self-care after traumatic injury and the use of the therapeutic self care scale in trauma populations. J Adv Nurs 2013 Feb;69(2):286-294. [CrossRef] [Medline]
  40. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986 Jan;24(1):67-74. [Medline]
  41. Spielberger C, Gorsuch R, Lushene R, Vagg P, Jacobs G. State-trait anxiety inventory. Redwood City, CA: Mind Garden; 1983.
  42. Spielberger C. State-trait anxiety inventory: a comprehensive bibliography, 2 edition. Palo Alto, CA: Consulting Psychologists Press; 1989.
  43. Capsana. 2012. Avez-vous bon coeur?   URL: [accessed 2017-08-10] [WebCite Cache]
  44. Cossette S, Frasure-Smith N, Dupuis J, Juneau M, Guertin M. Randomized controlled trial of tailored nursing interventions to improve cardiac rehabilitation enrollment. Nurs Res 2012;61(2):111-120. [CrossRef] [Medline]
  45. Hertzog M. Considerations in determining sample size for pilot studies. Res Nurs Health 2008 Apr;31(2):180-191. [CrossRef] [Medline]
  46. Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios L, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol 2010 Jan 06;10:1 [FREE Full text] [CrossRef] [Medline]
  47. Norman G, Zabinski M, Adams M, Rosenberg D, Yaroch A, Atienza A. A review of eHealth interventions for physical activity and dietary behavior change. Am J Prev Med 2007 Oct;33(4):336-345 [FREE Full text] [CrossRef] [Medline]
  48. Krebs P, Prochaska J, Rossi J. A meta-analysis of computer-tailored interventions for health behavior change. Prev Med 2010;51(3-4):214-221 [FREE Full text] [CrossRef] [Medline]
  49. Conway N, Webster C, Smith B, Wake D. eHealth and the use of individually tailored information: a systematic review. Health Informatics J 2017 Sep;23(3):218-233. [CrossRef] [Medline]
  50. Kelders S, Kok R, Ossebaard H, Van Gemert-Pijnen JE. Persuasive system design does matter: a systematic review of adherence to web-based interventions. J Med Internet Res 2012;14(6):e152. [Medline]
  51. Kohl L, Crutzen R, de Vries NK. Online prevention aimed at lifestyle behaviors: a systematic review of reviews. J Med Internet Res 2013;15(7):e146. [Medline]
  52. Cugelman B, Thelwall M, Dawes P. Online interventions for social marketing health behavior change campaigns: a meta-analysis of psychological architectures and adherence factors. J Med Internet Res 2011 Feb 14;13(1):e17 [FREE Full text] [CrossRef] [Medline]
  53. Free C, Phillips G, Galli L, Watson L, Felix L, Edwards P, et al. The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review. PLoS Med 2013;10(1):e1001362 [FREE Full text] [CrossRef] [Medline]
  54. Webb T, Joseph J, Yardley L, Michie S. Using the internet to promote health behavior change: a systematic review and meta-analysis of the impact of theoretical basis, use of behavior change techniques, and mode of delivery on efficacy. J Med Internet Res 2010 Feb 17;12(1):e4 [FREE Full text] [CrossRef] [Medline]
  55. González C, Blobel B, López DM. Adaptive intelligent systems for pHealth - an architectural approach. Stud Health Technol Inform 2012;177:170-175. [Medline]
  56. Cedillos-Whynott E, Wolfe C, Widmer C, Brust-Renck P, Weil A, Reyna V. The effectiveness of argumentation in tutorial dialogues with an intelligent tutoring system for genetic risk of breast cancer. Behav Res Methods 2016 Sep;48(3):857-868 [FREE Full text] [CrossRef] [Medline]
  57. Özyurt Ö, Özyurt H. Learning style based individualized adaptive e-learning environments: content analysis of the articles published from 2005 to 2014. Comput Human Behav 2015 Nov;52:349-358. [CrossRef]
  58. Fontaine G, Cossette S, Maheu-Cadotte MA, Mailhot T, Deschênes MF, Mathieu-Dupuis G. Effectiveness of adaptive e-learning environments on knowledge, competence, and behavior in health professionals and students: protocol for a systematic review and meta-analysis. JMIR Res Protoc 2017 Jul 05;6(7):e128 [FREE Full text] [CrossRef] [Medline]
  59. Steenbergen-Hu S, Cooper H. A meta-analysis of the effectiveness of intelligent tutoring systems on college students? academic learning. J Educ Psychol 2014;106(2):331-347. [CrossRef]
  60. VanLEHN K. The relative effectiveness of human tutoring, intelligent tutoring systems, and other tutoring systems. ‎Educ Psychol 2011 Oct;46(4):197-221. [CrossRef]

ACS: acute coronary syndrome
CCU: Coronary Care Unit
CR: cardiac rehabilitation
eHealth: electronic health
HIV: human immunodeficiency virus
ICTs: information and communications technologies
ITS: intelligent tutoring systems
RCT: randomized controlled trial
RN: registered nurse
SD: standard deviation
SRMTS: Self-Reported Medication-Taking Scale
TSCS: Therapeutic Self-Care Scale

Edited by G Eysenbach; submitted 17.01.17; peer-reviewed by L Park, C Thorup; comments to author 04.07.17; revised version received 06.07.17; accepted 12.07.17; published 06.09.17


©Sylvie Cossette, José Côté, Geneviève Rouleau, Marie Robitaille, Sonia Heppell, Tanya Mailhot, Guillaume Fontaine, Catherine Cournoyer, Marie-Pierre Gagnon, Maria-Cecilia Gallani, Jean-Francois Tanguay, Jocelyn Dupuis, Anil Nigam, Marie-Claude Guertin. Originally published in JMIR Cardio (, 06.09.2017.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Cardio, is properly cited. The complete bibliographic information, a link to the original publication on, as well as this copyright and license information must be included.