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Evaluation of Machine Learning Approaches for Predicting Warfarin Discharge Dose in Cardiac Surgery Patients: Retrospective Algorithm Development and Validation Study

Evaluation of Machine Learning Approaches for Predicting Warfarin Discharge Dose in Cardiac Surgery Patients: Retrospective Algorithm Development and Validation Study

Warfarin is a commonly prescribed oral anticoagulant for patients who have undergone cardiac surgery and remains the only guideline-endorsed anticoagulant for patients with mechanical heart valves. However, considerable interindividual variability exists in the response to warfarin, with patient age, BMI, concomitant medications, and genetic status imparting considerable influence on warfarin maintenance dose requirements [1-5].

Lindsay Dryden, Jacquelin Song, Teresa J Valenzano, Zhen Yang, Meggie Debnath, Rebecca Lin, Jane Topolovec-Vranic, Muhammad Mamdani, Tony Antoniou

JMIR Cardio 2023;7:e47262

Uptake and Utilization of the Management of Anticoagulation in the Periprocedural Period App: Longitudinal Analysis

Uptake and Utilization of the Management of Anticoagulation in the Periprocedural Period App: Longitudinal Analysis

While warfarin had been the only available oral anticoagulant for decades, 5 new direct oral anticoagulants have come to market in the United States since 2010, paralleled by an increase in outpatient anticoagulant use [5]. The proportion of ED visits due to anticoagulants has increased by 57% in that period, and anticoagulants now account for nearly 18% of all ADE-associated ED visits in the United States [1-4,6].

Alex C Spyropoulos, Anne Myrka, Darren M Triller, Stephen Ragan, Collin York, Jaz-Michael King, Ti-Kuang Lee

JMIR Mhealth Uhealth 2018;6(12):e11090