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Skip search results from other journals and go to results- 4 Journal of Medical Internet Research
- 3 JMIR Research Protocols
- 3 JMIR mHealth and uHealth
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After surgery, patients require lifelong anticoagulation therapy with vitamin K antagonists, such as warfarin, to prevent prosthetic valve thrombosis.
Current guidelines differ on the target international normalized ratio (INR) for patients with MAVR, especially those with additional thromboembolic risk factors.
JMIR Res Protoc 2025;14:e73389
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Warfarin, a traditional oral anticoagulant, which widely used in clinical practice, remains the primary medication for reducing the risk of thrombosis and stroke after heart valve replacement surgery [3-5]. Patients undergoing biological valve replacement typically require 3 to 6 months of oral warfarin therapy, while those with mechanical valves need lifelong anticoagulation.
JMIR Mhealth Uhealth 2025;13:e53586
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With a usage history spanning over 60 years, warfarin is currently the most widely used anticoagulant prescription drug for preventing thrombosis after heart valve surgery, orthopedic surgery, atrial fibrillation, and varicose veins of the lower extremities, as well as systemic embolism, pulmonary embolism, and venous thromboembolism [1]. Daily management of warfarin is highly correlated with clinical outcomes.
J Med Internet Res 2024;26:e46319
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Warfarin is a commonly prescribed oral anticoagulant for patients who have undergone cardiac surgery and remains the only guideline-endorsed anticoagulant for patients with mechanical heart valves. However, considerable interindividual variability exists in the response to warfarin, with patient age, BMI, concomitant medications, and genetic status imparting considerable influence on warfarin maintenance dose requirements [1-5].
JMIR Cardio 2023;7:e47262
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We will collaborate with their treating clinicians and calculate a warfarin initiation dose using the relevant algorithm.
Day 0 is considered the first day that warfarin is taken. We recruited participant up to 7 days before and no more than 1 day after warfarin was initiated, meaning some individuals may have taken a single warfarin dose. We will use a paper-based dosing table, using dose formulations currently available, which has been developed for implementation (Multimedia Appendix 1).
JMIR Res Protoc 2023;12:e46710
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Telemedicine-Based Management of Oral Anticoagulation Therapy: Systematic Review and Meta-analysis
Even in recent clinical trials of DOAC versus warfarin, TTR in control groups varied widely across various geographical regions [47], reaching values as low as 36% in India. Hence, e Health implementation may positively impact the quality of anticoagulation, especially in underserved regions.
The complexity and potential hazards associated with OAT, especially VKAs, make it a still underused therapy, and anticipation of difficulty in management is a frequent barrier to an adequate prescription of OAT [48].
J Med Internet Res 2023;25:e45922
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Approximately 8 million people in the United States received anticoagulants, including warfarin, in 2019 [1]. Warfarin is well known for having a multitude of drug-drug interactions (DDIs), with many avoided through health care provider awareness. However, studies found that up to 24% of people taking warfarin also received a prescription for nonsteroidal anti-inflammatory drugs (NSAIDs), and almost 50% of patients on warfarin have some form of ongoing pain [2,3].
JMIR Form Res 2022;6(10):e40018
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Warfarin, as an anticoagulation drug, is widely used in the prevention of various thromboembolic events [6], but it is not easy to control due to the narrow therapeutic range and patients’ heterogeneity. Therefore, the dosage of warfarin needs to be adjusted accordingly by the international normalized ratio (INR) [7,8].
J Med Internet Res 2021;23(8):e29529
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Without proper adjustment, excessive warfarin may cause bleeding, and inadequate warfarin doses may cause thrombosis and possible death [3]. This represents a costly use of medical resources and is physically and psychologically traumatic to patients and their families [4].
Warfarin dose adjustment is usually performed at hospital clinics. For patients living in rural areas, adjustment of warfarin dosages requires transportation, accommodation, and time.
JMIR Mhealth Uhealth 2021;9(3):e23332
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Oral anticoagulants (OACs) have been used for decades, especially warfarin, which has been in use since the 1950s. Until recently warfarin has been a fundamental drug in clinical anticoagulant therapy, and although the results of two previously published meta-analyses of atrial fibrillation suggested that novel OACs are not inferior to warfarin in terms of safety and efficacy [1,2], warfarin has the advantage of being inexpensive and having a wide range of indications.
J Med Internet Res 2020;22(7):e18386
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